Ask about this productRelated genes to: NDST4 antibody
- Gene:
- NDST4 NIH gene
- Name:
- N-deacetylase and N-sulfotransferase 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q26
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-12
- Date modifiied:
- 2016-07-05
Related products to: NDST4 antibody
Related articles to: NDST4 antibody
- Decades of intensive breeding for rapid growth rate has resulted in increased abdominal fat content in commercial broilers, which also led to significant economic loss in this industry. In the present study, we integrated RNA-Seq datasets of 44 samples, including 22 fat- and 22 lean-line, to identify the selection signatures linked to abdominal fat content in chickens. - Source: PubMed
Publication date: 2025/11/27
Abbasabadi HosseinBakhtiarizadeh Mohammad RezaMansourizadeh HosseinGutiérrez-Gil Beatriz - Rosa damascena is an ancient plant with significance in both medicine and perfumery that have a variety of therapeutic properties, including antidepressant, anti-anxiety, and anti-stress effects. Rose damascena essential oil (REO) has been used to treat depression, anxiety and other neurological related disorders in Iranian traditional medicine. However, its precise mechanism of action remains elusive. - Source: PubMed
Publication date: 2024/03/15
Xia NingWang JieGuo QiutingDuan JiaweiWang XuanZhou PeijieLi JinkaiTang TiantianLi TaotaoLi HuitingWu ZhenfengYang MingSun JingGuo DongyanChang XingZhang Xiaofei - Visual impairment is occasionally observed in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have been reported in MS and EAE, the precise mechanisms underlying the pathogenesis of these visual impairments remain poorly understood. This study aims to identify differentially expressed genes (DEGs) in the retinas of mice with EAE to identify genes that may be implicated in EAE-induced visual impairment. Fourteen adult mice were injected with myelin oligodendrocyte glycoprotein to induce the EAE model. Transcriptomes of retinas with EAE were analyzed by RNA-sequencing. Gene expression analysis revealed 347 DEGs in the retinas of mice with EAE: 345 were upregulated, and 2 were downregulated (adjusted -value < 0.05 and absolute log fold change > 1). Gene ontology (GO) analysis showed that the upregulated genes in the retinas of mice with EAE were primarily related to immune responses, responses to external biotic stimuli, defense responses, and leukocyte-mediated immunity in the GO biological process. The expression of six upregulated hub genes (, and t from the STRING analysis and the two significantly downregulated DEGs () were validated by reverse transcription-quantitative polymerase chain reaction. In addition, gene set enrichment analysis showed that the negatively enriched gene sets in EAE-affected retinas were associated with the neuronal system and phototransduction cascade. This study provides novel molecular evidence for visual impairments in EAE and indicates directions for further research to elucidate the mechanisms of these visual impairments in MS. - Source: PubMed
Publication date: 2023/10/04
Hong SungmooWeerasinghe-Mudiyanselage Poornima D EKang SohiMoon ChangjongShin Taekyun - The bladder exstrophy-epispadias complex (BEEC) is a spectrum of congenital abnormalities that involves the abdominal wall, the bony pelvis, the urinary tract, the external genitalia, and, in severe cases, the gastrointestinal tract as well. - Source: PubMed
Publication date: 2023/07/13
Köllges RicardaStegmann JilSchneider SophiaWaffenschmidt LeaFazaal JuliaBreuer KatinkaHilger Alina CDworschak Gabriel CMingardo EnricoRösch WolfgangHofmann AybikeNeissner ClaudiaEbert Anne-KarolinStein RaimundYounsi NinaHirsch-Koch KarinSchmiedeke EberhardZwink NadineJenetzky EkkehartThiele HolgerLudwig Kerstin UReutter Heiko - Heparan sulfate proteoglycans (HSPGs) are constituents of the cell surface and extracellular matrix and are vital for various activities within the cell. The N-deacetylase/N-sulfotransferase (heparin glucosaminyl) family of enzymes, or NDST, modifies heparan sulfate (HS) by catalyzing both the N-deacetylation and the N-sulfation of N-acetylglucosamine residues. In zebrafish, a single ndst3 gene is an orthologue of both mammalian NDST3 and NDST4 genes. The role of ndst3 in zebrafish development has not been investigated and such study may provide insight into the role(s) of both mammalian orthologues. Here, we characterized expression of ndst3 during early development in zebrafish and found it to be predominately neuronal. We found that expression of ndst3 is sensitive to Wnt signaling manipulation, with stimulation of the Wnt pathway resulting in robust expansion of ndst3 expression domains. Finally, using CRISPR/Cas9 genome editing, we mutagenized the ndst3 gene and isolated an allele, ndst3, resulting in a frameshift and premature protein truncation. We discovered Ndst3 is not essential for zebrafish survival as ndst3 homozygous mutants are viable and fertile. - Source: PubMed
Publication date: 2022/12/09
Anderson Rebecca AOyarbide Usua