Ask about this productRelated genes to: DPY19L2 antibody
- Gene:
- DPY19L2 NIH gene
- Name:
- dpy-19 like 2
- Previous symbol:
- -
- Synonyms:
- FLJ32949, SPATA34
- Chromosome:
- 12q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-19
- Date modifiied:
- 2016-04-14
Related products to: DPY19L2 antibody
Related articles to: DPY19L2 antibody
- This study investigated the impact of benzo[a]pyrene (BaP) exposure on male reproductive health, revealing a dose-dependent decline in sperm count, density, and serum testosterone levels. BaP exposure significantly impaired sperm motility, as evidenced by reduced kinematic parameters (VSL, VCL, VAP, LIN, STR, WOB). Molecular analysis demonstrated that BaP downregulated the expression of key genes, including ZMYND10 and its associated motility protein DNALI1, and the spermiogenesis regulator ZMYND15 along with its downstream targets (DPY19L2, AKAP4, AKAP3, SPEM1, PRM1, CATSPER3). These alterations in gene expression are linked to structural and functional deficits in sperm, such as abnormal morphology (coiled tails, folded heads) and impaired flagellar development. Our research infers that Bap diminishes sperm quality in male rats and induces reproductive harm by downregulating ZMYND15 and ZMYND10, hence influencing the expression of their associated genes. This study elucidates a novel mechanism for BaP-induced impairment of sperm quality. - Source: PubMed
Publication date: 2026/03/17
Zhao XinruiDong XiuxiaFu PengjuanChen YongkangLiu NaWang BoheFeng XiaojuanLi Xiangli - Teratozoospermia, characterized by a high proportion of morphologically abnormal sperm, severely impairs male fertility. This study focused on an infertile male patient presenting with globozoospermia and multiple morphological abnormalities of the flagella (MMAF), with the aim of uncovering the etiology of teratozoospermia. - Source: PubMed
Publication date: 2026/02/11
Liao HuijuanFu LonglongOuyang DiPeng LeixiRen KeyuWu ChengyuZheng YantongLi JinhongQin LangQiao XiaoyongBai YuLuo ShanLu WenhongYang Yihong - Globally, male infertility (MI) is a major concern. Several other comorbidities related to MI are testicular germ cell tumor (TGCT) and prostate adenocarcinoma (PRAD). This study focuses on finding the common biomarkers among these diseases and their interaction with Melatonin (MLT). The differential expressed genes were retrieved using the GEPIA2 database for TGCT and PRAD, whereas the DISGENET database for MI-related genes. InteractiVenn was performed in response to identify the common genes. The STAG3, RNF212, DDX3Y, DPY19L2, TPCN1, KLK3, GNRH1, DMD, CCDC146, and DNAH1 are found to be involved in all these diseases. The gene ontologies and pathway enrichment analysis were done for these significant genes in response to identifying and accessing the involvement of these genes in other processes. MLT is a neuroendocrine hormone with high therapeutic properties. MLT showed the best binding energy with DDX3Y among all the proteins. Molecular dynamic simulation (MDS) of MLT with DDX3Y was performed and found to be -52.382 ± 13.110 kJ/mol binding energy. The RMSD, RMSF, SASA, RG, H-bond, FEL, PCA, and MM-PBSA analysis confirm the stability and compactness of the DDX3Y-MLT complex. The MDS results indicate that MLT is a promising therapeutic option for enhancing DDX3Y expression, which will support spermatogenesis. Additionally, the hub genes were identified based on MCC parameters from the merged interactive network of common genes in response to finding significant genes that can be a potential biomarker for the diagnosis of diseases. - Source: PubMed
Publication date: 2025/03/08
Wanjari Uddesh RameshGopalakrishnan Abilash Valsala - Male infertility manifests in the form of a reduction in sperm count, sperm motility, or the loss of fertilizing ability. While the loss of sperm production can have mixed reasons, sperm structural defects, cumulatively known as teratozoospermia, have predominantly genetic bases. The aim of the present review is to undertake a comprehensive analysis of the genetic mutations leading to sperm morphological deformities/teratozoospermia. - Source: PubMed
Publication date: 2024/10/17
Arora ManviMehta PoonamSethi ShrutiAnifandis GeorgeSamara MarySingh Rajender - DNA methylation plays a critical role in regulating gene expression during testicular development. However, few studies report on candidate genes related to the DNA methylation regulation of porcine testicular development. This study examined the differentially expressed genes (DEGs) and their methylation levels in testicular tissues from pigs at 60 days of age (60 d) and 180 days of age (180 d) using RNA-Seq and whole genome bisulfite sequencing (WGBS). It was determined that DNA methylation primarily occurs in the cytosine-guanine (CG) context, and the analysis identified 106,282 differentially methylated regions (DMRs) corresponding to 12,385 differentially methylated genes (DMGs). Further integrated analysis of RNA-Seq and WGBS data revealed 1083 DMGs negatively correlated with the expression of DEGs. GO analysis showed that these genes were significantly enriched in spermatogenesis, germ cell development, and spermatid differentiation. The screening of enriched genes revealed that hyper-methylation repressed , , , , , , , and , while hypo-methylation elevated , , , , and expression. Additionally, the methylation status of the key genes , , , , , and was detected by bisulfite sequencing PCR (BSP). This study offers insights into the epigenetic regulation mechanisms underlying porcine testicular development. - Source: PubMed
Publication date: 2024/08/22
Feng YueZhang YuWu JunjingQiao MuZhou JiaweiXu ZhongLi ZipengSun HuaPeng XianwenMei Shuqi