Ask about this productRelated genes to: ZDHHC14 antibody
- Gene:
- ZDHHC14 NIH gene
- Name:
- zinc finger DHHC-type containing 14
- Previous symbol:
- -
- Synonyms:
- FLJ20984, NEW1CP
- Chromosome:
- 6q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-27
- Date modifiied:
- 2016-02-15
Related products to: ZDHHC14 antibody
Related articles to: ZDHHC14 antibody
- This study explores the links between palmitoylation-related genes and the progression of osteoarthritis (OA) and its downstream regulatory mechanism. - Source: PubMed
Publication date: 2026/04/08
Di JingkaiGuo ZijianChen TingtingHe JinsongQin YingdaWang FeidaXiang Chuan - Medication overuse headache (MOH) causes substantial disability in suffering patients, significantly reducing the quality of life. It may lead to structural and functional brain changes detectable by neuroimaging. Successful and effective treatments can alleviate headache burden, reduce consumption of abused drugs and reverse the biological alterations. Therefore, improvement of therapeutic strategies and optimization of patient stratification to match the individuals who can benefit with certain approaches, is essential. This study investigates DNA methylation (DNAm) associated with response to MOH treatment. - Source: PubMed
Publication date: 2026/04/02
Kwiatkowska Katarzyna MalgorzataFavoni ValentinaFerraresi FrancescaPirazzini ChiaraRavaioli FrancescoBacalini Maria GiuliaDall'Olio DanieleSala ClaudiaCastellani GastoneCalzari LucianoGentilini DavideTerlizzi RossanaPierangeli GiuliaCortelli PietroMascarella DavideGaragnani PaoloCevoli Sabina - S-palmitoylation, a reversible post-translational modification regulates protein stability and cellular functions, yet its role in glutamine metabolism remains unclear. Here, we show that ZDHHC14 as the key palmitoyltransferase catalyzing ASCT2 palmitoylation at conserved Cys39 and Cys48 residues, promoting lysosomal degradation of this glutamine transporter, whereas ABHD17B functions as a depalmitoylase to stabilize ASCT2. Mechanistically, glutamine deprivation activates JNK1, which directly phosphorylates ZDHHC14 at Thr440 residue, triggering its degradation and thereby enhancing ASCT2 stability. Importantly, combination of JNK and ASCT2 inhibitors synergistically inhibits glutamine metabolism and tumor growth in vivo. These findings reveal a phosphorylation-palmitoylation axis linking JNK-mediated ASCT2 palmitoylation and glutamine metabolism, offering a potential therapeutic strategy for non-small cell lung cancer. - Source: PubMed
Publication date: 2026/02/24
Chen XingyuKe ZihaoWei ShihuiChen JiajinZhu KeXu JiaqiZhao YunCen MengyuanJin YanPan ZhileiXiong JuanChen YingDong ChenfangCao QianhuaCao Chao - The progression of prostate cancer is closely associated with dysregulation of tumor suppressor genes. P16 (), a key cell cycle regulator, is frequently downregulated in malignant phenotypes, yet the role of its post-translational modifications, particularly palmitoylation, remains unclear. This study aimed to investigate the regulatory mechanism of palmitoylation on P16 stability and explore the functional role of ZDHHC14 in this process, as well as its impact on the malignant behaviors of prostate cancer cells. - Source: PubMed
Publication date: 2025/12/24
Zhao JianNi GangWu ZhichaoZhang Chunhong - Dysplastic nodules (DN) are precursors to cirrhosis-associated malignancy, and the HBV DNA integration in the human genome plays a critical role in tumorigenesis. However, the precise relationship between DN and HBV integration remains unclear. We performed HBV-capture sequencing on 19 cirrhosis patients with HBV infection (DN, 10; RN, 9), out of which 10 subjects (DN, 9; RN, 1) underwent RNA sequencing. In total, 1936 and 1450 HBV integration sites were identified in the DN and RN samples, respectively. The number of HBV integration sites in DN correlated with nodule size. Breakpoints in HBV genome were concentrated within 100 bps toward the 5' or 3' end of involved HBV genes. Furthermore, integration numbers also positively correlated with number of point mutations in DN samples. We identified 53 and 29 recurrent genes containing HBV integrations in ≥ 2 samples in DN and RN samples, respectively. Higher clonality was observed for HBV integrations in recurrent genes than other HBV-integrated genes. The HBV integrations in recurrent genes were predominantly located in intron regions. Notably, among those recurrently HBV-integrated genes in DN samples, SCHIP1, ZDHHC14, YPEL2, RABGAP1L, and SOX5 displayed significant expression alterations. Moreover, clinical indicators revealed significant prolongation of prothrombin time in two DN patients with HBV integrations in SCHIP1 and ZDHHC14. As a new insight regarding HBV integrations in DN stage, our findings suggest a possible role of HBV integration in the transformation of DN to early-stage liver cancer by affecting the expression of key genes. - Source: PubMed
Zeng XiLiu HuiXu ZheqiRao XinjieWang YuyouyePeng FangDong WeiWang ZiyingWang ZhenguangGu XingLiu FuchenLi GuoliangZhou WeipingZhao Linghao