Ask about this productRelated genes to: SERINC2 antibody
- Gene:
- SERINC2 NIH gene
- Name:
- serine incorporator 2
- Previous symbol:
- TDE2L
- Synonyms:
- FKSG84, PRO0899, TDE2
- Chromosome:
- 1p35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-23
- Date modifiied:
- 2016-10-05
Related products to: SERINC2 antibody
Related articles to: SERINC2 antibody
- Serine incorporator (SERINC) is a family of transmembrane protein involved in lipid synthesis. Among its family members, SERINC2 has been implicated in tumor pathogenesis. Pancreatic carcinoma (PAAD), a highly malignant tumor characterized by an extremely poor prognosis, lacks effective biomarkers. To date, the association between SERINC2 and pan-cancer or tumor immunity remains unreported in the literature. Consequently, investigating the utility of SERINC2 for prognostic prediction in PAAD lays the groundwork for developing diagnostic biomarkers and SERINC2-targeted immunotherapy strategies. In this study, we used the transcriptional data in normal and tumor tissues from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) and Human Protein Atlas (HPA). Analysis of publicly available data (TCGA, GTEx, HPA) revealed significant overexpression in multiple cancers, which was associated with advanced clinicopathological stage (<0.05). Analysis of the Genomic Stability Associated Cancer Analysis (GSCA) database revealed a significant positive correlation between copy number variation (CNV) and expression levels. Conversely, DNA methylation was inversely correlated with expression (<0.05). Further investigation utilizing TCGA database demonstrated that expression was significantly associated with the expression of immune checkpoint molecules, response to immunotherapy, and the extent of immune cell infiltration. Notably, a negative correlation was observed between expression and the tumor microenvironment (TME) score in most cancer types analyzed (<0.05). We constructed a prognostic model for PAAD based on 25 differentially expressed genes (DEGs) identified from the TCGA cohort using the "limma" package. This model effectively stratified patients into high- and low-risk groups with significantly distinct survival outcomes. Immunohistochemical (IHC) analysis of 54 PAAD patient samples validated that high expression was significantly associated with poorer prognosis; patients with high expression had a significantly shorter median overall survival (19.67 50.52 months, =0.029). Collectively, our findings provide a rationale for developing SERINC2-based diagnostic biomarkers and immunotherapeutic strategies. - Source: PubMed
Zhao MinYing Hui-QiYang Yi-LeiChen Qing-LvLin WenCai Zhen-ZhaiLin Li-MiaoTeng Yang-Yang - Doxorubicin (DOX) is a highly effective anthracycline chemotherapy drug that is commonly used in clinical practice. Because of the accumulation of its drug concentration, their clinical use is associated with severe cardiotoxicity. Serine incorporator 2 (Serinc2) had been shown to play an important role in maintaining cell structure and function. Here, the main purpose of this study was to explore the effect of Serinc2 on doxorubicin-induced cardiotoxicity and its mechanism. - Source: PubMed
Publication date: 2026/01/22
Hu ShanYang ManqiLiu TaoHuang MinJu HaoLiu ZheyuKashkooli SaeedCheng MianWu Gang - Early cancer diagnosis is essential for improving prognosis and guiding treatment. However, the high dimensionality and complexity of omics data present major challenges. Computational approaches that extract stable biomarkers and enable reliable classification across cancer types and stages are needed. - Source: PubMed
Publication date: 2025/12/17
Ghaleb Moshira SAl-Berry Maryam NEbied Hala MTolba Mohamed F - Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduced expression in BDII patient plasma, which correlated with the disease severity. Using induced pluripotent stem cell (iPSC) models of sporadic and familial BDII patients, we found that Serinc2 expression showed deficits in iPSC-derived microglia-like cells, resulting in decreased synaptic pruning. Further, combining the microglia-specific Serinc2-deficient mouse and iPSC-microglia models, we found that microglial Serinc2 deficits functioned through attenuating the synthesis of serine-related phospholipids in the plasma membrane, thus resulting in depression-like behavioral abnormalities in the animals. Finally, we showed that the Serinc2-dependent lipid deficits diminished microglial membrane CR3 formation to interrupted synaptic pruning signals from neurons. Therefore, our results indicated that Serinc2 deficits in microglia might contribute to the pathogenesis of BD. - Source: PubMed
Publication date: 2025/09/08
Wang Ying-HanFu Chong-LeiChen Lin-BoZhang Chu-YiChen Jian-ShanZhang Qiao-MingLiang YiruiYang Rui-LanLi YuZhang Ya-NiHan Yi-NuoYuan Zhen-LiangChen Yi-NiLi HaimeiPan YanmengHu ShaohuaLi MingCao Li-PingYao Jun - Serine Incorporator 2(SERINC2), a highly conserved eukaryotic membrane lipid regulator, promotes critical membrane lipid biosynthesis to maintain neuronal metabolic homeostasis by assembling serine synthase complexes. Our team previously identified SERINC2 as a bipolar disorder (BD) risk gene in Chinese Han familial BD cases, with mutations affecting cerebral white matter volume. Despite established clinical relevance, brain expression patterns of SERINC2 remains poorly characterized experimentally. We used RNAscope® in situ hybridization to comprehensively map SERINC2 mRNA distribution across mouse coronal brain sections, and quantified positive cells across regions. Given BD's potential association with excitatory/inhibitory imbalance, multiplex fluorescence in situ hybridization examined SERINC2 co-expression patterns with vesicular glutamate transporter 2 (VGLUT2, marker for glutamatergic neurons) and glutamic acid decarboxylase 2 (GAD2, marker for GABAergic neurons) in SERINC2-positive regions. Widespread SERINC2 expression was observed in in the telencephalon and diencephalon, including cortical areas (neocortex and limbic cortex), hippocampal subregions (CA1 - CA3, dentate gyrus, and subiculum), thalamic nuclei, and basolateral amygdala. High-intensity signals were detected in hindbrain regions, particularly the pontine nuclei (PN) and reticulotegmental nucleus of the pons (RtTg). Cerebellar Purkinje and granular layers also exhibited significant expression. Notably, multiplex fluorescence in situ hybridization revealed SERINC2 + /VGLUT2 + co-expression in cortical layers III-IV, dorsal subiculum, thalamus, PN, and RtTg. Co-expression of SERINC2 + /GAD2 + was identified in the cerebellar Purkinje cell layer. These findings delineate the brain-wide expression landscape of SERINC2 in mice and provide a neuroanatomical basis for studying its role in excitation/inhibition imbalance in the pathogenesis of BD. - Source: PubMed
Publication date: 2025/08/18
Ke TianlangYang RuilanTan ZewenCao LipingLiu Xuemei