Ask about this productRelated genes to: JAM3 antibody
- Gene:
- JAM3 NIH gene
- Name:
- junctional adhesion molecule 3
- Previous symbol:
- -
- Synonyms:
- JAM-C, JAMC
- Chromosome:
- 11q25
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-26
- Date modifiied:
- 2016-04-25
Related products to: JAM3 antibody
Related articles to: JAM3 antibody
- - Source: PubMed
Publication date: 2026/04/20
Tanveer Fariha ShahidSaeed Muhammad HassanZaidi Tafazzul Hyder - - Source: PubMed
Publication date: 2026/04/20
Peng HuanziLi JingZhou QunZhou HuiPeng JiaqiWang JingLiu PeiHe KunLiu WeneTan PingLi LeiXie Xiaobing - Rapeseed (Brassica napus L.) is a global oilseed crop, crucial for meeting the increasing global demand for both vegetable oil and protein-rich animal feed. Transcriptional regulation centrally governs carbon allocation for oil and protein biosynthesis in seeds; however, the key regulators that coordinate these pathways to balance oil and protein levels in B. napus seeds remain largely unknown. In this study, we found that BnaC03.TERMINAL FLOWER 1 (BnaC03.TFL1) and BnaC09.TFL1 function additively to promote soluble sugar and oil biosynthesis while repressing protein deposition, with BnaC03.TFL1 playing the predominant role. BnaC03.TFL1 physically interacts with four BnJASMONATE ASSOCIATED MYC2 LIKE 3 (BnJAM3) proteins that also function additively in enhancing soluble sugar and oil biosynthesis and reducing protein production. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSugar Will Eventually be Exported Transporters (BnSWEETs). This complex directs carbon flux into fatty acid biosynthesis at the expense of storage protein production, ultimately fine-tuning seed oil and protein accumulation. Our findings uncover a BnTFL1-BnJAM3-BnSWEETs module that transcriptionally reprograms carbon partitioning to fine-tune oil and protein accumulation in B. napus seeds. - Source: PubMed
Publication date: 2026/04/09
Wang JianjunLiu ZijinJin MinshanLiu JuntingWei ShihaoYang DengmaoYang SaiqiGuo YuanChen Mingxun - This study performed a systematic investigation through proteomic and longitudinal follow-up data from the UK Biobank (comprising 70 schizophrenia cases and 36,135 healthy controls) to reveal the association between protein biomarkers and the onset of schizophrenia in order to provide insights into the pathogenesis of schizophrenia. Cox regressions recognized 31 significant schizophrenia related proteins (P < 1.712 × 10) and five of them also had non-linear associations with schizophrenia. The joint effect of 31 proteins was measured through Lasso-Cox regression, in which 17 proteins had non-zero coefficients. Mendelian randomization indicated JAM3 as having positive causal relationship (β = 0.1459, P = 0.0043) with schizophrenia. The well performance (AUC = 0.7930 (0.7908, 0.7951), G-mean = 0.6683 (0.6652, 0.6714)) of LightGBM model which consisted of protein and population features presented a strong and robust predictive ability of our findings. Furthermore, the investigation on biological functions of 31 proteins showed the enrichment in cell adhesion, integrin binding, chemotaxis and extracellular matrix organization through enrichment analyses. - Source: PubMed
Publication date: 2026/04/04
Wu SongyuGuo XinruJia TingyiSun ZhouyangYu GeOuyang YixinKou ChangguiBai Wei - The early and accurate diagnosis of cervical precancerous lesions is essential for mitigating the risk of cervical cancer. Given the limitations of traditional screening methods, such as inadequate sensitivity and low specificity, this study aims to assess the diagnostic performance of combined PAX1/JAM3 gene methylation testing for cervical intraepithelial neoplasia (CIN) and to explore its potential in triage management. Methylation testing serves as a tool for investigating the epigenetic alterations associated with diseases like cancer, thereby providing molecular biological evidence for diagnosis and prognosis. - Source: PubMed
Publication date: 2026/03/17
Fan GuoXiaolu YuKeremu YiliminuerWeina KongXiaohui XuXiumin Ma