Ask about this productRelated genes to: PILRA antibody
- Gene:
- PILRA NIH gene
- Name:
- paired immunoglobin like type 2 receptor alpha
- Previous symbol:
- -
- Synonyms:
- FDF03
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-10
- Date modifiied:
- 2016-03-15
Related products to: PILRA antibody
Related articles to: PILRA antibody
- Schizophrenia (SCZ) is a complex psychiatric disorder, and its pathogenic mechanisms are not yet fully understood. The identification of reliable blood biomarkers and molecular subtypes for early diagnosis and effective therapy remains a significant challenge. To address this issue, we utilized a combination of bioinformatics and machine learning (ML) to identify potential biomarkers for SCZ. Our approach involved the integration of 12 different ML algorithms to develop a diagnostic signature based on data from several datasets, including GSE18312, GSE27383, GSE38485, GSE54913, and GSE165604. A nomogram was constructed using these datasets for potential clinical applications. In addition, clustering analysis was performed on SCZ patients using consensus clustering and non-negative matrix factorization (NMF) algorithms. We further evaluated subtype differences in biological functions and immune cells through various methods, such as gene set enrichment analysis (GSEA), gene set variation analysis (GSVA), Proteomaps, and IOBR analyses. Our results identified a diagnostic signature composed of 16 genes (APBB2, CLCN1, SYDE1, PAX5, SNAI1, DAZL, UNC93B1, PLAGL2, HS3ST1, ITPKB, PILRA, BTLA, SWAP70, AZI2, ADM, and AVPR2), which demonstrated robust performance in diagnosing SCZ across eight different datasets. A nomogram based on these genes was created, providing clinical benefits for SCZ patients. Among the identified genes, AZI2 was found to be the most critical, influencing inflammation and immunity. We also identified potential chemical compounds that could target these 16 genes. Unsupervised clustering and NMF algorithms revealed two distinct subtypes of SCZ, each associated with unique immune cell profiles, biological functions, and protein expression levels. In conclusion, this study not only developed a diagnostic signature and a novel nomogram for SCZ but also provided new insights into the subtypes of SCZ. These findings may pave the way for personalized diagnosis and treatment strategies for SCZ patients. - Source: PubMed
Publication date: 2026/03/24
Li ZhijunSun QingLi HaoyuGuan NaiyuNi JingWang JingXu XiaoleiShen YeSun SiyuLi Yan - The cerebrospinal fluid (CSF) proteome offers a direct readout of central nervous system (CNS) biology but its genetic architecture remains incompletely defined. We conducted the largest single-site CSF genome-wide association study (GWAS) to date, analysing 7,092 SomaScan proteins in 1,259 individuals. Using a covariate-adjusted model including proteomic PCs and disease status, we identified 1,971 genome-wide significant pQTLs (954 cis, 971 trans), 1,409 of which replicated in an independent CSF dataset. We discovered 264 previously unreported loci, replicated 511 associations, refined 80 known loci, and 265 proxy-based associations. Using a previously published reproducibility framework, we show that robust discovery concentrates in reliable measurements, underscoring the importance of rigorous quality control. Enrichment analyses revealed immune/complement and extracellular matrix biology. Mendelian randomization prioritised causal proteins: PILRA, TREM2, IL34, CR2, SHARPIN and ERBB1 (Alzheimer's disease); BST1 and GPNMB (Parkinson's disease); STX6 (Creutzfeldt Jacobs disease); and ATXN3 and B4GALNT1 (Amyotrophic lateral sclerosis), providing a scalable framework for orthogonal target validation in neurodegeneration. - Source: PubMed
Publication date: 2026/02/22
Puerta RaquelGarcía-González Pablode Rojas ItziarCapdevila-Bayo MariaOlivé ClàudiaMuñoz-Morales ÁlvaroBayón-Buján PaulaValenzuela AlejandroYang ChengranTimsina JigyashaLiu MenghanChakkarai SathyaseelanSotolongo-Grau OscarCalm BertaMiguel AndreaSolivar AriadnaMontrreal LauraMartínez MartaKhan AsifZhao FeiyangTantinyà NatàliaRosende-Roca MaitéeAlegret MontserratMoreno-Grau SoniaFernández Maria VictoriaMarquié MartaValero SergiCavazos Jose EnriqueSanz PilarMontalban XavierTàrraga LluisSmets BartBoada MercèSeshadri SudhaSargurupremraj MuralidharanCruchaga CarlosCano AmandaCabrera-Socorro AlfredoRuiz Agustín - The complex tumor microenvironment (TME) of colorectal cancer (CRC), composed of diverse cellular components and dynamic interactions, constitutes a major barrier to effective immunotherapy and facilitates disease progression. There is a pressing need to elucidate CRC-intrinsic factors that induce the immunosuppressive TME. Here, we explored the role of homeobox D13 (HOXD13) in shaping the immune microenvironment of CRC and its contribution to immunosuppression. - Source: PubMed
Publication date: 2026/02/24
Chen XilangChen JieYin YueSun MengyuLi SiwenZhang JiaqianWu ZhangfanJiang JunqingHu DianFan DaimingNie YongzhanHuang WenjieWu KaichunXia Limin - Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a membrane-associated receptor involved in immune regulation and signal transduction. However, its expression and functional role in breast cancer remain largely unknown. This study investigated the expression, mutation, and DNA methylation patterns of PILRA in breast cancer, along with its impact on immune infiltration and associated pathways. We also evaluated its potential as a therapeutic target for predicting prognosis and guiding immunotherapy in breast cancer. - Source: PubMed
Publication date: 2026/01/16
Shi BowenYang YanXing LeiChen Junxia - Diabetes is a well-known risk factor for pancreatic adenocarcinoma (PAAD), yet the underlying molecular mechanisms remain unclear. This study employs single-cell sequencing to analyze gene expression patterns and uses Mendelian randomization to assess the association between genetic variations in specific genes and the risk of PAAD. Our findings reveal a significant reduction in the proportion of monocytes in patients with both diabetes and PAAD. Monocytes play a crucial role in the progression of both diseases. Notably, we identified an increase in intermediate monocytes (CD14 + + CD16+) in both conditions. These cells exhibit significant activation of the LGALS9-CD45 receptor, increased metabolic activity, and enhanced involvement in disease pathways. We demonstrate that intermediate monocytes are key cellular players in the link between diabetes and PAAD. Using dual-sample Mendelian randomization, we identified genetic variations in PILRA, a highly variable gene in intermediate monocytes, as a risk factor for PAAD. PILRA + intermediate monocytes show higher metabolic activity and stronger immune cell communication compared to PILRA- cells, suggesting an important role in tumor microenvironment regulation and immune cell activation inhibition. This biological function is associated with cytokine-mediated signaling, focal adhesion, and NOD-like receptor signaling pathways. RT-qPCR validation of PBMC samples indicates a statistically significant, progressive increase in PILRA expression in patients with PAAD, diabetes, and those with both conditions. In summary, this study uncovers the critical role of intermediate monocytes in diabetes-induced PAAD and proposes PILRA as a potential therapeutic target. - Source: PubMed
Publication date: 2026/01/17
Lv ChaoLiu ZhenhuaZhang ShuaiminYang ShengpengWang GuoliangXiao Jingjing