Ask about this productRelated genes to: SC5DL antibody
- Gene:
- SC5D NIH gene
- Name:
- sterol-C5-desaturase
- Previous symbol:
- SC5DL
- Synonyms:
- -
- Chromosome:
- 11q23.3-q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-12
- Date modifiied:
- 2018-07-27
Related products to: SC5DL antibody
Related articles to: SC5DL antibody
- Migraine and Meniere’s disease (MD) show high clinical comorbidity, shared symptoms such as vertigo and overlapping mechanisms like neurogenic inflammation suggest common pathophysiology. However, the core immunogenetic drivers underlying this comorbidity, particularly at cellular resolution, remain uncharacterized. - Source: PubMed
Publication date: 2026/04/18
Hu XiaoWang YangYu Si-JiePan Chun-YaLiang Bing-YuJiang Shang-ShangChen Shan-WenHan Yan-Xun - This research investigated selenomethionine (SeMet) alleviating cadmium (Cd) toxicity in hybrid yellow catfish. Four groups were established: control group (CK), cadmium group (Cd), selenium group (Se), and cadmium‑selenium co-treatment group (Cd + Se). The results demonstrated that Cd decreased the specific growth rate and weight gain rate of fish while increasing the feed coefficient ratio (P < 0.05). It also induced severe gill and liver tissue damage. Se alleviated Cd-induced growth inhibition, repaired the tissue damage, and reversed Cd-triggered increase of serum alanine aminotransferase and aspartate aminotransferase (P < 0.05). Regarding antioxidant capacity, Se reversed Cd-induced declines in total antioxidant capacity, total superoxide dismutase, catalase, and glutathione peroxidase activities, while mitigating hydrogen peroxide and malondialdehyde accumulation in the liver, gill, and serum (P < 0.05). Immunological analysis indicated that Cd suppressed lysozyme, acid phosphatase, and alkaline phosphatase activities, while Se restored these enzymatic activities to normal or higher levels (P < 0.05). Metabolic analysis revealed that Se reduced liver total cholesterol content in the Cd-exposed group and restored serum cholesterol to normal levels (P < 0.05). Furthermore, transcriptomic results demonstrated that Se antagonized Cd toxicity through dual regulatory mechanisms: (1) restoring the genes of iron metabolism (steap3, ncoa4) to control levels and upregulating the cystine/glutamate transporter system (Xc-system) gene slc3a2b, thereby protecting cells from ferroptosis; (2) downregulating cholesterol synthesis genes (msmo1, sc5d), thereby blocking Cd-induced aberrant cholesterol synthesis. These molecular findings aligned with physiological indicators, demonstrating that Se mitigated Cd toxicity in fish via a multi-target regulatory mechanism. - Source: PubMed
Publication date: 2025/07/12
Xu QianTang QianYi LinyuanGong YuanShen ZhigangYuan Yongchao - Matrine, the main active ingredient in Sophora flavescens and Sophorae tonkinensis radix et rhizome, is a highly effective insecticide. However, its hepatotoxicity to some extent affects its application value. This study aimed to explore the mechanism underlying matrine-induced liver injury. - Source: PubMed
Publication date: 2025/04/17
Tao XiaoyuZhang WentingChen LinzhenLu ShanLi ZhiqiGao YifeiFan QiqiLi JiaqiWu JiaruiZhao Chongjun - Long-term statin use has been linked to increased diabetes risk. Iron metabolism disruption may explain this association. The objective of this study was to identify the co-expression gene modules and the iron metabolism-related gene (IMG) linking statin administration and diabetes, making the hunt for novel therapeutic targets necessary. - Source: PubMed
Publication date: 2025/03/27
Huang YiJiaChen KaiXiao XiaoZhong Shilong - High temperature restricts the survival and growth of aquatic organisms. Probiotics have significant potential for mitigating the negative effects of temperature stress on fish. In this study, the American shad (Alosa sapidissima), a temperature-sensitive freshwater fish, was selected as the experimental paradigm to dissect the underlying mechanisms governing the interactions between the host and its microbiome, with a particular focus on the impact exerted by the probiotic Lactococcus lactis within a high-temperature setting. We evaluated the effects of probiotics on the growth and biochemistry of A. sapidissima by measuring relevant parameters and enzyme activities and conducted an integrated microbiome-transcriptome analysis to assess the impacts on the gut microbiota and uncover probiotic-regulated metabolic pathways. The findings of our research indicated that probiotics had beneficial effects on growth; the activities of enzymes such as LPS, T-SOD, and GSH-PX; and the gut microbial composition. Furthermore, the configuration of the intestinal microbiota underwent a transformation, as evidenced by the increased relative prevalence of bacteria with potential beneficial properties, including Bacillus, Lactococcus, and Clostridium. Liver transcriptomic analysis revealed 586 differentially expressed genes (DEGs). The expression of immune-related genes (nfil3-2, il17d, and leap2) and lipid metabolism-related genes (pla2g3 and sc5d) was strongly upregulated. KEGG enrichment analysis revealed that the DEGs were predominantly clustered within metabolic pathways such as circadian rhythm and fatty acid degradation. This study revealed that probiotics enhanced intestinal bacterial diversity and eased stress by regulating the circadian rhythm, immunity, and lipid metabolism under high-temperature conditions. This study provides a reference for the use of probiotics in A. sapidissima at high temperatures. - Source: PubMed
Publication date: 2025/03/03
Qiu ChuwenShi YonghaiHuang XuxiongChen Zaizhong