Ask about this productRelated genes to: NTSR1 antibody
- Gene:
- NTSR1 NIH gene
- Name:
- neurotensin receptor 1
- Previous symbol:
- -
- Synonyms:
- NTR
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-30
- Date modifiied:
- 2016-10-05
Related products to: NTSR1 antibody
Related articles to: NTSR1 antibody
- Pepducins are synthetic membrane-tethered lipopeptides designed to allosterically modulate G protein-coupled receptor (GPCR) signaling. Here, we characterize a series of pepducins targeting the neurotensin receptor type 1 (NTSR1), revealing their complex and multifaceted modulation properties. Using BRET-based biosensors, we show that PP-001, a pepducin derived from NTSR1's first intracellular loop, preferentially activates G protein over -arrestin signaling while inhibiting NT binding, NT-induced -arrestin recruitment, and NTSR1 internalization, thereby acting as biased allosteric agonist and negative allosteric modulator. PP-001 also promotes the formation of both homo- and heteromeric multi-receptor complexes. , PP-001 elicits potent, sustained hypotensive effects, reversible by the NTSR1 antagonist SR48692. Although the precise mechanism of pepducin-receptor interaction remains unclear, we identify a critical N-terminal RKK motif for PP-001's biological activity. Finally, thermodenaturation assays using purified NTSR1, combined with mutagenesis and molecular docking, provide evidence for the role of the receptor's H8 domain in direct pepducin interaction. Together, these findings highlight pepducins as versatile modulators of GPCR function and as valuable pharmacological tools for GPCR-targeted drug development. - Source: PubMed
Publication date: 2025/12/30
Brouillette Rebecca LLussier FrédériqueBreault ÉmileMeneboo NathanHassanzadeh MaliheTremblay VictoriaChartier MagaliMidavaine ÉloraUlrich LaurenceCôté JérômeBlais VéroniqueMona Christine ELongpré Jean-MichelGrandbois MichelBoudreault Pierre-LucAudet MartinBesserer-Offroy ÉlieSarret Philippe - Breast cancer (BC) is a biologically heterogeneous disease, and no single imaging modality captures the full spectrum of phenotypes across all stages of the disease. This review summarizes advances in receptor-targeted nuclear imaging approaches that support patient stratification, treatment selection and response monitoring. - Source: PubMed
Publication date: 2026/04/26
Paraïso Pvan Deurzen C H MSeimbille Y - Precise genetic access to molecularly defined neuronal subpopulations is essential for dissecting circuit heterogeneity. We report the development and validation of a knock-in neurotensin receptor 1 (Ntsr1)-FlpO mouse line enabling intersectional targeting of Ntsr1-expressing neurons. Following Flp-dependent adeno-associated viral (AAV) reporter delivery, we observed robtust recombination in the substantia nigra and ventral tegmental area, revealing that midbrain Ntsr1 populations include both dopaminergic and non-dopaminergic neurons. Systemic retro-orbital delivery of a Cre- and Flp-dependent Con/Fon reporter in complementary dual-recombinase configurations demonstrated orientation-dependent differences in dopaminergic targeting specificity. Cis-gene controls defined the maximal achievable dopaminergic ceiling and demonstrated that persistent non-dopaminergic populations exceed expectations from recombinase inefficiency alone. Finally, a dual-recombinase-dependent taCaspase-3 construct enabled intersectional ablation of midbrain dopamine neurons in vivo. Together, these findings establish Ntsr1 as a physiologically neutral, intersectionally compatible driver line supporting scalable Boolean targeting using local and systemic AAV strategies. - Source: PubMed
Publication date: 2026/03/12
Garcia FernandoVilla Andrew PWong Justine TFenno Lief ELeinninger Gina MSteele Andrew D - Lung adenocarcinoma (LUAD) is a leading cause of cancer death. Neurotensin receptor 1 (NTSR1), a G protein-coupled receptor, is overexpressed in LUAD and linked to poor prognosis, but its therapeutic potential is underexplored. - Source: PubMed
Publication date: 2026/03/25
Wang YongfuLiu WeiTao PengzhuoLiu ChangminYuan YizhenXue YajingYang HantingLiu XiongfengZhou XinyiChen ShilinSong Chi - Projections from widefield vertical (WFV) cells of the superior colliculus to the pulvinar nucleus form a conserved pathway for motion detection across mammalian species. While subtypes of tectopulvinar cells have been identified in the ground squirrel, it is unclear whether subtypes can be identified in mice. Using viral tracing, immunohistochemistry, and confocal and electron microscopy in Tac1, Ntsr1-GN209, and C57BL/6J mice, we attempted to characterize WFV cells based on their morphology, pulvinar projection patterns, expression of substance P, parvalbumin, or hyperpolarization-activated cation channels (HCN1), and their retinal innervation. We found that the Ntsr1-GN209 line labels a subset of tectopulvinar cells that lack parvalbumin but express HCN1. Furthermore, comparison of previous ultrastructural datasets revealed that Ntsr1-GN209 WFV cells innervate the pulvinar with synaptic terminals that are smaller than the overall population of tectopulvinar terminals. However, using retrograde, anterograde, and transsynaptic viral tracing, we found that in all three mouse lines, WFV cells could not be subdivided based on their dendritic arbors or projections to the lateral pulvinar (Pl) or caudal medial pulvinar (Pcm). We also found that a subset of WFV cells receive ipsilateral retinal input, but these cells did not differentially innervate the Pl or Pcm. Finally, we found that the retina provides one-third of the synaptic input to Ntsr1-GN209 WFV cells and primarily innervates their small distal dendrites. Together, our data indicate that although the Ntsr1-GN209 line labels a subset, the overall population of mouse WFV cells cannot be subdivided based on features identified in the ground squirrel. - Source: PubMed
Naeem NSlusarczyk A SBickford M E