Ask about this productRelated genes to: UNC5A antibody
- Gene:
- UNC5A NIH gene
- Name:
- unc-5 netrin receptor A
- Previous symbol:
- -
- Synonyms:
- KIAA1976, UNC5H1
- Chromosome:
- 5q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-09
- Date modifiied:
- 2018-11-22
Related products to: UNC5A antibody
Related articles to: UNC5A antibody
- Myoblasts autonomously govern myofiber-type specification of newly formed myotubes through autocrine-paracrine-dependent manners mediated by multipotent modulators. Netrin-1, which is particularly produced in myoblasts isolated from the extensor digitorum longus (EDL; fast-twitch myofiber-abundant) rather than the soleus (slow-twitch myofiber-abundant), and netrin-4, which is abundantly expressed during myogenic differentiation initiation, stimulate the synthesis of fast-type myosin heavy chain (MyHC) isoforms. However, the mechanisms by which netrin-1 and netrin-4 promote fast-twitch myotube formation remain unclear. Here, we investigated the roles of netrin receptors, uncoordinated-5 homologues (UNC5A, -B, -C, and -D), deleted in colorectal cancer (DCC), and the DCC paralog (neogenin) during myogenic differentiation, focusing on fast-twitch myotube formation. We confirmed that UNC5A, UNC5B, UNC5C, and neogenin synthesis patterns in EDL myoblasts showed no marked differences compared with those in soleus myoblasts. Notably, UNC5A knockdown severely inhibited fast-twitch myotube formation compared with other receptor knockdown treatments and significantly reduced the synthesis of fast-type MyHC isoforms. Additional treatment with recombinant netrin-1 or netrin-4 induced fast-type MyHC mRNA expression; however, this effect was suppressed by UNC5A knockdown. These findings revealed that UNC5A is involved in fast-twitch myotube formation via netrin ligands, highlighting an autonomous fast-type myofiber commitment system within myoblasts. - Source: PubMed
Maeno TakahiroUshijima TomokiOjima KoichiOgawa YoheiHayashi SayukiImakyure HikaruOsaki RikaOyama RyukiOgawa AoiTakano AkimasaMizoguchi KaoruYokoyama IsseiKomiya YusukeNakamura MakoTatsumi RyuichiSuzuki Takahiro - Recent evidence suggests that the basement membrane (BM) plays an important role in the progression of colorectal cancer (CRC). Here, we investigate the prognostic value of CRC based on BM-associated genes. BM-related differentially expressed genes (DEGs) in CRC were obtained through analysis of The Cancer Genome Atlas public database and literature. The DEGs were used to cluster tumor samples and perform survival analysis. A prognostic model was constructed based on the DEGs in CRC through regression analysis, and its predictive effect was evaluated and validated using the GEO dataset. The correlation between riskscore and tumor progression was evaluated, and Cox regression was used to verify the independence of riskscore by combining it with different clinical factors. A nomogram was drawn to predict the prognosis of CRC individuals. The differences in immune microenvironment between high-risk (H) and low-risk (L) groups were analyzed by ssGSEA and ESTIMATE. The tumor mutation burden (TMB) was calculated for the two groups. Drug sensitivity prediction was performed for the two groups. Finally, the expression levels of prognostic feature genes were validated through qPCR. Based on BM-related DEGs, CRC samples were classified into 2 clusters, with cluster 1 having significantly lower survival rates. A prognostic model was developed based on 7 genes (AGRN, TIMP1, UNC5A, SPARCL1, ADAMTS6, MMP1, and UNC5C). The model exhibited high predictive accuracy and demonstrated the potential to serve as an independent prognostic factor for predicting the prognosis of CRC individuals. A higher riskscore indicated a higher degree of tumor progression. Group H demonstrated higher levels of immune infiltration and TMB, suggesting that individuals in this group might be more suitable for immune therapy. Two first-line anti-tumor drugs, Gemcitabine and Cisplatin, with higher sensitivity to individuals in group L were obtained. The q-PCR results of the feature genes were consistent with the results of gene expression in the database. This study established a 7-gene BM-related prognostic model that could be used to analyze the immune landscape of CRC individuals and predict their sensitivity to immunotherapy and chemotherapy. This research provided a reference for the prognosis prediction and immunotherapy of CRC individuals. - Source: PubMed
Publication date: 2025/08/02
Yang LeileiJi ZhiqingRen YufengFang ChengfengHan JiajuLuo DinghaiZhang RuiliZhou Shenkang - Egg quality directly determines embryo development in meat-type poultry. However, it is difficult to directly select the egg quality of Muscovy duck. The genes and SNPs associated with egg quality screened by GWAS can be used for molecular breeding and accelerate the progress of selection in Muscovy duck. - Source: PubMed
Publication date: 2025/04/29
Yang WanliYu ShiqiSong DanyuLin WeihuangXu HanqiLang XuqiaoZhang ChengGuo LipingChen Xingyong - UNC5A had been reported to play crucial roles in multiple cancers. However, little was known about the associations among UNC5A and glioma. Therefore, we first combined scRNA-seq, proteomics, as well as bulk RNA-seq in order to investigate UNC5A's functions in gliomas. - Source: PubMed
Publication date: 2024/07/22
Qian WenboZhang LeiZhang FenglinYe JingliangWan ZhipingChen HuairuiLuo Chun - Colorectal cancer (CRC) is the most common malignancy affecting the gastrointestinal tract. Extensive research indicates that basement membranes (BMs) may play a crucial role in the initiation and progression of the disease. - Source: PubMed
Publication date: 2024/07/01
Shengxiao XiangXinxin SunYunxiang ZhuZhijie TangXiaofei Tang