Ask about this productRelated genes to: DHCR24 antibody
- Gene:
- DHCR24 NIH gene
- Name:
- 24-dehydrocholesterol reductase
- Previous symbol:
- DCE
- Synonyms:
- KIAA0018, seladin-1
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-27
- Date modifiied:
- 2019-04-23
Related products to: DHCR24 antibody
Related articles to: DHCR24 antibody
- Minimising methane (CH) emissions from livestock production is a global priority, and feed modifications, such as supplementing diets with microalgae, have previously been shown to help reducing enteric CH production. This study explored blood-derived host gene expression profiles from twenty lambs supplemented with increasing levels of microalgae oil to investigate their transcriptional responses associated with varying microalgae oil levels while also exploring the host systemic responses towards varied CH productions. - Source: PubMed
Publication date: 2026/06/23
Chacko Kaitholil Steffimol RoseMooney Mark HAubry AurélieCristobal-Carballo OmarHillis RichardRazban VahidYan TianhaiRezwan Faisal IMorrison StevenHuws SharonShirali Masoud - The reproductive performance of geese is regulated by the hypothalamic-pituitary-ovarian (HPO) axis, which controls ovarian follicular development and hormone secretion, and ultimately determines egg production. In this study, Wanxi White geese at three reproductive stages (pre-laying, laying, and broody periods) were used to investigate the regulatory roles of circadian clock genes in follicular development. Results showed that follicular growth, serum levels of estradiol (E2), melatonin (MLT), and progesterone (P4) markedly increased during the laying period, whereas a higher number of atretic follicles was observed during the broody period. Correspondingly, expression of steroidogenesis-related genes (CYP11A1, CYP19A1, DHCR24, 3β-HSD and StAR) and melatonin synthesis-related gene (ASMT-1) was upregulated in the laying periods compared with pre-laying and broody periods. Moreover, expression of clock genes (CLOCK, PER2, CRY1, CRY2, ARNTL2A, EYA3 and NPAS2) was significantly higher in the hypothalamus during the laying period than that in the broody period. Notably, CLOCK, PER2, CRY1, CRY2 and DIO2 exhibited similar expression patterns in the hypothalamus and ovary across the three reproductive stages, suggesting that circadian clock genes may contribute to the coordination of hypothalamic and ovarian functions. In addition, genes involved in lipid metabolism and yolk precursor synthesis were markedly upregulated in both the liver and ovary during the laying period. Overall, the elevated expression of clock genes could play an important role in follicular development, hormone secretion, and the coordinating of hepatic lipid transport and yolk precursor formation, providing a theoretical basis for improving egg production and breeding strategies in Wanxi White geese. - Source: PubMed
Publication date: 2026/06/10
Zhu DengxuLiu YanyanZhu ShijiWu YukangZhang YuhaoWang HuiyuJiang YanQian JinjingWang ShujuanLiu Wenju - With the ongoing integration of offshore wind power and marine aquaculture, increasing attention has been paid to the potential biological effects of continuous low-frequency noise generated during wind farm operations on surrounding fish species. In this study, juvenile black scrapers (Thamnaconus modestus), a demersal species with low auditory sensitivity, were exposed to 500 Hz noise at low, medium, and high intensities (root-mean-square (RMS) sound pressure levels (SPLrms): 95 ± 5, 115 ± 5, and 135 ± 5 dB re 1 μPa) for 14 days to investigate physiological responses and molecular regulatory mechanisms. Low-intensity noise primarily suppressed the expression of feeding and digestion genes (Ghrl, Prss1) and activated oxidative stress and neuroprotective pathways. Medium-intensity noise caused dysregulation of lipid metabolism genes (Gba1, Degs2), significantly elevated malondialdehyde (MDA) content, and downregulated the expression of key genes in the neutrophil extracellular trap formation pathway (Ncf1, Ncf2, Ncf4). High-intensity noise disrupted the expression of circadian clock genes (Bmal1, Per2) and upregulated cholesterol synthesis pathway genes (Sqle, Cyp51a1, Dhcr24). Collectively, long-term low-frequency noise exposure during operation induced dose-dependent physiological stress on juvenile T. modestus, affecting digestive function, redox balance, lipid metabolism, immune responses, and circadian rhythm regulation. These findings contribute to understanding the potential impacts of low-frequency noise from offshore wind farms on marine fish and suggest that low-frequency noise should be incorporated as a key assessment criterion in the siting of marine ranching and fishery resource conservation. - Source: PubMed
Publication date: 2026/06/09
Song ShiqiShan Xiujuan - The limited efficacy of immunotherapy in hepatocellular carcinoma (HCC) is largely attributed to the formation of an immunosuppressive tumor microenvironment, in which abnormal cholesterol metabolism plays an important role. Here, we investigated the effects of signaling lymphocytic activation molecule family member 7 (SLAMF7) on the cholesterol metabolism of HCC. - Source: PubMed
Publication date: 2026/06/09
Weng JialeiWang FuXu WenxinZhao LiqianChang YushunLu HaowenXu KaiZheng HemingWang YifanCai Xiujun - Obesity and its associated disorders of glucose and lipid metabolism have become increasingly significant public health concerns. Bariatric surgery is an effective intervention for severe obesity and related metabolic comorbidities. This study aims to investigate the effects of bariatric surgery on glucose and lipid metabolism in high-fat diet (HFD)-induced obese mice. - Source: PubMed
Guo ZhonghaoZhao ShengjieWang WeiLi Ruibin