Ask about this productRelated genes to: TRAF3IP3 antibody
- Gene:
- TRAF3IP3 NIH gene
- Name:
- TRAF3 interacting protein 3
- Previous symbol:
- -
- Synonyms:
- T3JAM
- Chromosome:
- 1q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-02
- Date modifiied:
- 2016-10-05
Related products to: TRAF3IP3 antibody
Related articles to: TRAF3IP3 antibody
- The tumor suppressor KDM6A/UTX, a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic environment, opposite from the pseudo-hypoxia observed in VHL-mutated renal carcinomas. Mechanistically, KDM6A sustains the expression of the coil-coil domain gene CCDC3, which inhibits CREB1-driven transcription of the mitochondrial regulator PPARGC1A. In the hematological cancer multiple myeloma where KDM6A is frequently deleted, its loss similarly promotes oxidative phosphorylation, but via an alternative mechanism: the increased transfer of mitochondria from stromal to myeloma cells via tunneling nanotubes, triggered by the loss of the mTORC1 inhibitor TRAF3IP3. Beyond cancer, KDM6A regulates oxidative phosphorylation also during development and in adult tissues, engaging either the CCDC3-CREB1 or the TRAF3IP3-mTORC1 pathways. These mutually exclusive associations suggest a tissue-level convergent evolution, positioning KDM6A as a central modulator of mitochondrial activity through context-specific partners. - Source: PubMed
Publication date: 2026/09/04
Cartalemi Antonino AlexRosano DaliaFerrari CamillaCrupi GemmaCassina LauraGatti GuidoCorigliano FedericaPunzi SimonaVillanti IlariaDupéré-Richer DaphnéD'Ercole ChiaraRuggieri VeronicaMiluzio AnnaritaBruno TizianaGarcia Manteiga Jose ManuelGiansanti ValentinaBennett Richard LCittaro DavideMadaro LucaBoletta AlessandraPievani TelmoBiffo StefanoFanciulli MaurizioCiboddo MicheleLicht JonathanTonon Giovanni - Skeletal muscle fiber composition plays a critical role in determining muscle growth and meat quality in livestock species. However, the molecular mechanisms underlying muscle fiber-type transformation in meat rabbits remain poorly understood. - Source: PubMed
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Jia ChengQianwen WuZhengwei JiZhongqiang YaoLing WangHongzhao LuWenxian Zeng - Interferon-based local therapy is an intervention for high-risk human papillomavirus (HR-HPV)-associated low-grade squamous intraepithelial lesions (LSIL) or lower-grade cervical abnormalities. This study sought to delineate the differences in clinical outcomes following interferon-based local drug treatment and elucidate the microenvironmental factors driving these disparities. - Source: PubMed
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Ji LingyunWu JingZhou YangPu XiaowenWang XiaoXu BowenJiao RuixianWu WenjuanZhang Wenhong - Phosphatase and tensin homolog (PTEN) is a critical regulator of cell proliferation, differentiation, and inflammatory balance. However, its downstream proteomic effects in periodontal ligament stem cells (PDLSCs) remain poorly understood. This study aimed to elucidate the proteomic alterations induced by PTEN inhibition and identify potential molecular pathways underlying periodontal regeneration. - Source: PubMed
Publication date: 2026/03/20
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