Ask about this productRelated genes to: TMCO1 antibody
- Gene:
- TMCO1 NIH gene
- Name:
- transmembrane and coiled-coil domains 1
- Previous symbol:
- TMCC4
- Synonyms:
- HP10122
- Chromosome:
- 1q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-19
- Date modifiied:
- 2016-04-25
Related products to: TMCO1 antibody
Related articles to: TMCO1 antibody
- To assess how whole genome sequencing and varying phenotype definitions influence genetic discovery for primary open-angle glaucoma (POAG) in a diverse population. - Source: PubMed
Publication date: 2026/03/22
Aboobakar Inas FCruz Lauren AKinzy Tyler GLuo YuyangNallapaneni SanjanaDo RonVy Thi HaZhao HetinceTran JessicaHysi Pirro GKhawaja Anthony PGharahkhani PuyaPasquale Louis RHauser Michael A Segrè Ayellet VCrawford Dana CWiggs Janey LCooke Bailey Jessica N - Asthenozoospermia (AS), a prevalent contributor to male infertility, remains incompletely characterized at the metabolic level. This study aimed to define the energy metabolic profile of AS spermatozoa and identify key proteins associated with observed dysregulations. Sperm samples from 19 AS patients and 21 normozoospermic (NS) controls were analyzed. Aliquots from each sample were used to quantify energy-metabolic parameters [oxidative phosphorylation (OXPHOS)/glycolytic ATP production rates, electron-transport chain complex activities, reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP)] and perform proteomic sequencing. Differentially expressed proteins (DEPs) underwent functional enrichment analysis. Spearman correlation linked DEPs to energy-metabolic parameters to identify pathogenesis-associated candidates. AS spermatozoa demonstrated significantly reduced OXPHOS-derived ATP production, impaired electron-transport chain complex activities, decreased MMP, and elevated ROS levels compared to NS controls. Proteomic analysis identified 205 DEPs, with aerobic respiration as the top enriched pathway. Correlation analysis revealed significant associations between OXPHOS ATP/MMP parameters and six DEPs [Dickkopf (DKK)3, KAD9, TMCO1, DRC10, NDUAD, DCAF8]. DKK3 exhibited pronounced expression in human reproductive tissues and localized to the sperm mitochondrial sheath. Dkk3 knockout (KO) mice displayed phenotypes mirroring clinical AS, including reduced motility and mitochondrial dysfunction. Collectively, our integrated human and murine data demonstrate significant OXPHOS impairment with elevated ROS levels in asthenozoospermic sperm, phenotypes recapitulated in Dkk3-KO models. These findings support DKK3 deficiency as a contributor to AS pathogenesis through mitochondrial bioenergetic dysregulation. Further interventional studies remain essential to define mechanistic links between DKK3 loss and compromised sperm mitochondrial function and motility. - Source: PubMed
Xue RuizhiZhang LonglongShi RuikangQin WeijunCao XiaomingYang Fa - To investigate the impact of high expression of transmembrane and coiled helix structural domain 1 (TMCO1) on prognosis of gastric cancer and the possible mechanisms. - Source: PubMed
Song BowenZhou RenjieXu YingShi JinranZhang ZhizhiLi JingGeng ZhijunSong XueWang LianWang YueyueZuo Lugen - This study aims to identify new genetic loci associated with primary open-angle glaucoma (POAG) and explore shared genetic risk factors across African, European, and Admixed American/Latino populations. Genome-wide Association Study (GWAS) utilizing data from the Research Program. The study included 374,254 participants, with 4,305 individuals diagnosed with POAG and 369,949 controls. Participants were categorized by ancestry: European, African, and Admixed American/Latino. We used short-read sequencing data and applied strict quality control measures (MAF > 0.01, INFO > 0.8). GWAS were conducted for each ancestry group using a logistic mixed model, adjusting for age, sex, and the top 11 principal components. A fixed-effect meta-analysis combined the results across ancestries. Genome-wide significance was set at p<5×10. The primary outcome measures were the identification of genetic loci associated with POAG, and the analysis of transcription factors linked to these loci in relevant tissues. In the European cohort, we identified four novel loci associated with POAG, linked to the genes, as well as the previously known locus. In the African cohort, we found five new loci, including . For the Admixed American/Latino cohort, we identified genes as novel loci. Our analysis identified three novel loci in individuals of European ancestry, mapped to the genes . In addition, five novel loci were detected in the GWAS of African ancestry participants, and four novel loci were identified in individuals of Admixed American/Latino ancestry. These findings indicate that the genetic determinants contributing to POAG may differ across populations, underscoring the importance of accounting for population-specific genetic architectures in the study of complex traits. Given the substantial variation in POAG prevalence among ancestries, it is plausible that certain genetic variants exert ancestry-specific effects. Consequently, conducting ancestry-stratified GWAS is essential for elucidating these unique genetic contributions. - Source: PubMed
Publication date: 2025/10/26
Tavakoli KianaHuang Bonnie BMirmira TaraMa NicholeWeinreb Robert NBaxter Sally L - • ALADAPA is a rare congenital anomaly that can be a challenge to diagnose. • This is an interesting association of ALADAPA with TMCO1 mutation and Cohen syndrome. • It is critical to delineate the origins of all three coronary arteries. - Source: PubMed
Publication date: 2025/07/25
Mital RahulPak Yea-LynNento Daniel ESingh Harinder RStrainic James PAgarwal Arpit K