Ask about this productRelated genes to: C3ORF18 antibody
- Gene:
- C3orf18 NIH gene
- Name:
- chromosome 3 open reading frame 18
- Previous symbol:
- -
- Synonyms:
- G20
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-10
- Date modifiied:
- 2016-10-05
Related products to: C3ORF18 antibody
Related articles to: C3ORF18 antibody
- Insulin acts on adipocytes to suppress lipolysis and increase glucose uptake to control whole-body glucose and lipid metabolism. Regulation of these processes by insulin signalling depends on changes in protein localisation. However, the extent of insulin-stimulated changes to the adipocyte spatial proteome, and the importance of these in the cellular insulin response, is unknown. Here, we use subcellular proteomics approaches to map acute insulin-stimulated protein relocalisation in adipocytes on a cell-wide scale. These data reveal extensive insulin-regulated protein redistribution, with hundreds of insulin-responsive proteins. These include the uncharacterised protein C3ORF18, which redistributes to the plasma membrane in response to insulin. Studies in C3ORF18-depleted adipocytes suggest this protein is required to maintain adipocyte insulin sensitivity. Overall, our data highlight the scale of protein relocalisation in the adipocyte insulin response, and provide an accessible resource to inform further studies into how changes in protein localisation contribute to cellular insulin responses. - Source: PubMed
Publication date: 2026/02/28
Conway Olivia JChristopher Josie ABreckels Lisa MLi HanqiMenon DilipBirla MeghnaHawkins Bethan LLiang LuPatel SatishKoumanov FrancoiseGershlick David CSavage David BWeekes Michael PLilley Kathryn SFazakerley Daniel J - Sleep apnea is regarded as a significant global public health issue. The relationship between sleep apnea and nervous system diseases is intricate, yet the precise mechanism remains unclear. - Source: PubMed
Publication date: 2023/12/28
Gui JianxiongMeng LinxueHuang DishuWang LingmanYang XiaoyueDing RanHan ZiyaoCheng LiJiang Li - Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a proteome-wide association study (PWAS) analysis. Then two transcriptome reference weights (Rnaseq and Splicing) were applied to a transcriptome-wide association study (TWAS) analysis. Finally, the PWAS and TWAS results were investigated through brain imaging analysis. In the PWAS analysis, 8 and 13 candidate genes were identified in the ROS/MAP and Banner reference weight groups, respectively. Examples included ( = 3.00 × 10) and ( = 7.07 × 10). Moreover, the TWAS also detected multiple candidate genes associated with PTSD in two different reference weight groups, including ( = 3.84 × 10), ( = 5.09 × 10), and ( = 4.81 × 10). Further comparison of the PWAS and TWAS results in different populations detected the overlapping genes: ( = 4.90 × 10, = 1.23 × 10) in the total population and ( = 4.89 × 10, = 1.41 × 10) in females. Brain imaging analysis revealed several different brain imaging phenotypes associated with and genes. Our study identified multiple candidate genes associated with PTSD in the proteome and transcriptome levels, which may provide new clues to the pathogenesis of PTSD. - Source: PubMed
Publication date: 2022/07/27
Zhang ZhenMeng PeilinZhang HuijieJia YumengWen YanZhang JingxiChen YujingLi Chun'ePan ChuyuCheng ShiqiangYang XuenaYao YaoLiu LiZhang Feng - Objective: Bitter or sweet beverage perception is associated with alterations in brain structure and function. Our aim is to analyze the genetic association between bitter or sweet beverage perception and human brain proteins. Materials and methods: In our study, 8356 and 11,518 proteins were first collected from two reference datasets of human brain proteomes, the ROS/MAP and Banner. The bitter or sweet beverage perception-related proteome-wide association studies (PWAS) were then conducted by integrating recent genome-wide association study (GWAS) data (n = 422,300) of taste perception with human brain proteomes. The human brain gene expression profiles were collected from two reference datasets, including the brain RNA-seq (CBR) and brain RNA-seq splicing (CBRS). The taste perception-related transcriptome-wide association studies (TWAS) were finally performed by integrating the same GWAS data with human brain gene expression profiles to validate the PWAS findings. Results: In PWAS, four statistically significant proteins were identified using the ROS/MAP and then replicated using the Banner reference dataset (all permutated p < 0.05), including ABCG2 for total bitter beverages and tea, CPNE1 for total bitter beverage, ACTR1B for artificially sweetened beverages, FLOT2 for alcoholic bitter beverages and total sweet beverages. In TWAS analysis, six statistically significant genes were detected by CBR and confirmed by the CBRS reference dataset (all permutated p < 0.05), including PIGG for total bitter beverages and non-alcoholic bitter beverages, C3orf18 for total bitter beverages, ZSWIM7 for non-alcoholic bitter beverages, PEX7 for coffee, PKP4 for tea and RPLP2 for grape juice. Further comparison of the PWAS and TWAS found three common statistically significant proteins/genes identified from the Banner and CBR reference datasets, including THBS4 for total bitter beverages, CA4 for non-alcoholic bitter beverages, LIAS for non-grape juices. Conclusions: Our results support the potential effect of bitter or sweet beverage perception on brain function and identify several candidate brain proteins for bitter or sweet beverage perception. - Source: PubMed
Publication date: 2022/05/23
Wei WenmingCheng BolunHe DanZhao YijingQin XiaoyueCai QingqingZhang NaChu XiaogeShi SirongZhang Feng - The authors describe on a Brazilian girl with coronal synostosis, facial asymmetry, ptosis, brachydactyly, significant learning difficulties, recurrent scalp infections with marked hair loss, and elevated serum immunoglobulin E. Standard lymphocyte karyotype showed a small additional segment in 7p21[46,XX,add(7)(p21)]. Deletion of the TWIST1 gene, detected by Multiplex Ligation Probe-dependent Amplification (MPLA) and array-CGH, was consistent with phenotype of Saethre-Chotzen syndrome. Array CGH also showed deletion of four other genes at 7p21.1 (SNX13, PRPS1L1, HD9C9, and FERD3L) and the deletion of six genes (CACNA2D2, C3orf18, HEMK1, CISH, MAPKAPK3, and DOCK3) at 3p21.31. Our case reinforces FERD3L as candidate gene for intellectual disability and suggested that genes located in 3p21.3 can be related to hyper IgE phenotype. - Source: PubMed
Publication date: 2012/05/24
Zechi-Ceide Roseli MariaRodrigues Melina GuerreiroJehee Fernanda SarquisKokitsu-Nakata Nancy MizuePassos-Bueno Maria RitaGuion-Almeida Maria Leine