Ask about this productRelated genes to: CHIC2 antibody
- Gene:
- CHIC2 NIH gene
- Name:
- cysteine rich hydrophobic domain 2
- Previous symbol:
- -
- Synonyms:
- BTL
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2015-11-05
Related products to: CHIC2 antibody
Related articles to: CHIC2 antibody
- Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase fusions (M/LN-eo-TK) are uncommon but highly treatable disorders. Among them, FIP1L1::PDGFRA-driven disease is distinguished by marked eosinophilia and multisystem involvement that can rapidly reverse with targeted therapy. We describe a 50-year-old man with uncontrolled diabetes who presented with progressive dyspnea, abdominal discomfort, and painful necrotic scrotal ulcers. Laboratory testing revealed leukocytosis with a striking absolute eosinophil count of 22.1 × 10³/µL, while imaging showed pulmonary infiltrates, small-bowel inflammation, and splenomegaly. Bone marrow examination demonstrated hypercellularity with prominent eosinophilic proliferation. Fluorescence in situ hybridization confirmed a PDGFRA rearrangement with CHIC2 deletion, establishing the diagnosis of FIP1L1::PDGFRA-positive M/LN-eo-TK. Imatinib was initiated at 400 mg daily, later reduced to 200 mg, leading to a rapid normalization of eosinophil counts and resolution of systemic and dermatologic manifestations within 2 weeks. The case highlights how delayed recognition of clonal eosinophilia can permit extensive organ injury, whereas early molecular testing and prompt initiation of imatinib yield dramatic clinical and hematologic remission. Persistent hypereosinophilia, particularly with cutaneous or gastrointestinal involvement, should prompt evaluation for PDGFRA-rearranged disease to enable early intervention and prevent irreversible tissue damage. - Source: PubMed
Publication date: 2026/01/14
Calderon AuraGoyal ShubhankLoayza Pintado JoseCantazaro BrandonCobos Everardo - The development of transition metals as electrode materials that can exhibit good conductivity and fast electron transfer ability through electroactive sites is highly desirable because high sensitivity and selectivity can be achieved. When compared to other nonmetals, boron (B) possesses a lower electronegativity (χB-2.04) than carbon (χC-2.55), nitrogen (χN-3.04), and oxygen (χO-3.44) and thus forms a covalent linkage with electron-rich transition metals (Co or Fe) to form monometallic or bimetallic borides (CoB/FeB or CoFeB). However, the formation of crystalline bimetallic borides using conventional synthesis approaches is highly challenging. In this regard, for the first time in the present work, we developed crystalline bimetallic cobalt-iron boride (CoFeB) with nanostructure features via a chemical reduction and thermal annealing process as an efficient electrode material for the electrochemical detection of paracetamol. After the postannealing process, the obtained amorphous borates (CoFeOBO) are transformed into a highly crystalline form composed of bimetallic borides as revealed from X-ray diffraction (XRD) analysis. The resultant CoFeB coated on a screen-printed electrode (SPE) showed well-defined oxidation and reduction peaks with potentials of about = +0.51 V and = +0.44 V (vs Ag/AgCl) for paracetamol (pH = 7.2). At an optimized applied potential of +0.60 V (vs Ag/AgCl), a linear - response for paracetamol was observed from 0.01 μM to 2.7 mM with a good sensitivity of 64.79 μA mM cm and a low detection limit of 3.8 nM. In addition, CoFeB/SPE is found to be tolerable against interference species and shows agreeable repeatability and durability. Based on these results, the present work could develop a facile approach to producing a variety of metallic borides by tuning the composition of various transition elements, where high conductivity and stability are required in various electrocatalytic and electrochemical applications. - Source: PubMed
Publication date: 2025/10/10
Ashamary FrancisManoj ArunElancheziyan MariRaji AtchudanAnnamalai PadmanabanWon KeehoonYang Hsi-HsienKalambate Pramod KNellaiappan SubramanianManoj Devaraj - In vivo CRISPR screens in CD8 T cells have previously uncovered targets for cancer immunotherapy; however, a minority of the genome has been individually annotated, suggesting that additional regulators remain to be discovered. Here we assessed 899 genes in CD8 T cells responding to murine melanoma and identified the E3 ubiquitin ligase STUB1 as a new negative regulator of anti-tumor CD8 T cell function. We demonstrated that Stub1 knockout CD8 T cells effectively control tumor growth across multiple murine models. Mechanistically, STUB1 interacts with the adapter protein CHIC2 to regulate cytokine receptor expression in mouse and human CD8 T cells. Among the regulated cytokine receptors, interleukin-27 receptor α is essential for tumor growth control mediated by Stub1/Chic2 knockout CD8 T cells. Together, these findings establish the STUB1-CHIC2 complex as a regulator of cytokine receptor expression in CD8 T cells and provide rationale for inhibiting this pathway to enhance CD8 T cell-mediated anti-tumor immunity. - Source: PubMed
Publication date: 2025/08/12
LaFleur Martin WMilling Lauren EPrathima PriyamvadaLi VivianLemmen Ashlyn MStreeter Ivy S LHeisig Paul K SDerosia Nicole MRiffo ElizabethXu HaonanNguyen Thao HKolengaden AashiyaMarkson Samuel CDoench John GSharpe Arlene H - Approximately 10% of Ph-Like patients have ABL class gene fusions, which include the FIP1L1::PDGFRA rearrangement. We report a case of a pediatric patient with Ph-like B-lymphoblastic leukemia (B-LL) with a FIP1L1::PDGFRA fusion and their treatment course using a combination of chemotherapy and targeted therapy with imatinib. A 10-year-old female presented with lethargy, palpitations, and fevers. She had pancytopenia, no eosinophilia, and flow cytometry consistent with B-LL. FISH identified a CHIC2 deletion, suggestive of FIP1L1::PDGFRA fusion, confirmed on next-generation RNA sequencing. The patient commenced targeted therapy with imatinib, which she continued until completion of standard chemotherapy per COG AALL1732. She remains in remission 6 months post-completion of therapy. B-ALL with a FIP1L1::PDGFRA fusion is extremely rare, particularly in pediatrics. FIP1L1::PDGFRA rearrangements can be difficult to detect on routine testing and may not always be seen in association with eosinophilia. Identification of FIP1L1::PDGFRA rearrangements is important as they enable treatment with a tyrosine kinase inhibitor, which has significantly improved the overall prognosis for PDGFRA-rearranged neoplasms. Prospective studies assessing imatinib dosage, duration, and long-term safety are warranted in this cohort. - Source: PubMed
Nunn JennaWilliams BronwynDeambrosis David - Mashona is a Sanga breed believed to be an ancient Bos taurus and Bos indicus composite. Since importation to the United States producers with relatively small herds (<70 cows per herd) and located in hot-humid regions have found them useful in crossbreeding programs due to purported resistance to pests and heat stress. This study evaluated the genomic composition of U.S. Mashona to better understand their population history and determine the level of genetic diversity. Twenty-four Mashona from Tennessee State University were sampled and genotyped. A reference population of B. taurus (Angus, Hereford, Wagyu, Romosinuano, and Florida Cracker) and Bos indicus (Brahman) breeds, as well as from an additional Sanga breed (Tuli) was obtained from the USDA-ARS gene bank. All individuals were genotyped using the 777k Illumina BovineHD panel. Genomic diversity across breeds was evaluated using measures of genetic distance, allelic frequency, inbreeding, and admixture analyses. The principal component analysis results revealed the first 4 principal components to explain 15.5%, 4.3%, 3.1%, and 2.4% of the genetic variation in the genotyped animals. Mashona and Tuli did not overlap but tended to cluster near one another for all principal components, particularly along the 4th principal component (variation along the European-African axis). The ADMIXTURE analysis revealed that the average proportion of B. taurus genetics in Mashona was 0.81, with individual proportions ranging from 0.77 to 0.84. Additionally, the unsupervised ADMIXTURE analysis indicated that Mashona and Tuli form a distinct ancestry group, suggesting that Sanga breeds possess unique genetic diversity compared to the other breeds evaluated in this study. The evaluation of regions with high autozygosity or differentiated from other breeds revealed several selection signatures in the Mashona population. A run of homozygosity (ROH) region on chromosome 6 contained genes associated with horn fly resistance. Additional ROH regions contained genes and quantitative trait loci associated with calving ease, reproduction, and maternal ability. Historical trends in Mashona's effective population size (Ne = 28) align with known past demographic events and indicate a narrowing of its genetic base. With insights into Mashona's unique level of genetic diversity but its relatively small population size, breeders will need to balance existing genetic diversity and selection for important traits. - Source: PubMed
Ling Ashley SHay El HamidiLozada-Soto Emmanuel AHayes EmilyBrowning RichardBlackburn Harvey D