Ask about this productRelated genes to: ATP2A3 antibody
- Gene:
- ATP2A3 NIH gene
- Name:
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
- Previous symbol:
- -
- Synonyms:
- SERCA3
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-20
- Date modifiied:
- 2016-10-05
Related products to: ATP2A3 antibody
Related articles to: ATP2A3 antibody
- Dopaminergic (DA) neurons are highly susceptible to endoplasmic reticulum (ER) burden and redox imbalance, which drive their degeneration and contribute to Parkinson's disease (PD) pathogenesis. Previous work established METTL14-mediated N6-methyladenosine (m6A) modification as critical for dopaminergic (DA) neuron survival. Here, we delineate the underlying mechanism by which m6A dysregulation triggers neurodegeneration through the post-transcriptional modulation of key target genes. Using Mettl14 conditional knockout mice, we identified the ER calcium channel ATP2A3-a key calcium homeostasis regulator and known PD biomarker-as a major target of METTL14. METTL14 deficiency significantly reduced ATP2A3 expression, thereby exacerbating ER homeostasis and oxidative stress, ultimately leading to DA neuronal death. Restoring METTL14 in vivo alleviates motor deficits and neurodegeneration. Our findings reveal that m6A-mediated regulation of ATP2A3 bridges RNA epigenetic dysregulation to PD pathogenesis, highlighting this axis as a potential therapeutic target in this disease. - Source: PubMed
Publication date: 2026/03/17
Teng YanLiu ZhihaoWei FanTang QinLi ManjunChen XingminYi JinHe ShuXu JianliHang YuqingWang KaifangLiu YanzhuoJiang HaisongLe WeidongYang Lu - Lead (Pb) exposure is a risk factor of male infertility, while the transcriptional and epigenetic changes associated with lead exposure in spermatozoa are poorly understood. Our previous findings revealed significant changes in DNA methylation of the calcium (Ca) homeostasis pathway of human spermatozoa in men with a blood Pb level over 5 µg dl-1, which was associated with decreased sperm motility. In this study, we explored the effects of Pb exposure on expression of differentially methylated genes (DMGs) by analyzing semen samples from six healthy, non-smoking, and non-drinking men (aged 20-40 years). Using methylated DNA immunoprecipitation sequencing (MeDIP-seq) and RNA sequencing (RNA-seq), we compared DNA methylation and RNA abundance patterns between two groups: three men with blood Pb level 0-2.5 µg dl-1 and three men with blood Pb level 5-10 µg dl-1. Additionally, we experimentally validated the regulatory function of the differentially methylated regions associated with 11 hub genes using dual-luciferase reporter assays. We revealed differences in promoter activity between methylated and unmethylated promoter regions of seven cloned genes, namely calcium voltage-gated channel subunit alpha1 H (CACNA1H), calcium voltage-gated channel subunit alpha1 G (CACNA1G), calcium voltage-gated channel subunit alpha1 I (CACNA1I), calcium/calmodulin dependent protein kinase II gamma (CAMK2G), ATPase sarcoplasmic/endoplasmic reticulum Ca²+ transporting 3 (ATP2A3), solute carrier family 8 member A2 (SLC8A2), and glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D). Our results of Pb exposure-induced expression changes of essential genes associated with the calcium signaling pathway, particularly CACNA1H, SLC8A2, and GRIN2D, in spermatozoa, may be a potential cause of low sperm quality. - Source: PubMed
Publication date: 2026/01/13
Zhang XuShen Xiao-RongWu BinWang Xue-MeiShi Hui-JuanZhang Tian-Cheng - Anoikis, a recently identified type of programmed cell death analogous to apoptosis, has been implicated in the pathogenesis of Sjögren's syndrome (SS). Although accumulating evidence indicates its involvement in modulating immune responses and contributing to SS progression, the precise role of anoikis in SS remains inadequately understood. This study aimed to explore anoikis-related genes (ARGs) and their molecular mechanisms in SS using public databases. - Source: PubMed
Publication date: 2025/11/03
Wang LeiZhou ZiqiZhou XinpengLiu YingWang Mengjie - Gut microbiota plays a significant role in maintaining the homeostasis of the gut internal environment, and the volatile fatty acids (VFAs) produced by it are the main source of energy utilization for the host. The cardiac, as a key metabolic organ of the body, its energy metabolism efficiency directly affects the body's tolerance to the hypoxic environment at high altitudes. To reveal the dynamic regulatory relationship between the rumen and the cardiac of Hu sheep during their response to the high-cold and hypoxic environment. This study conducted transcriptome sequencing on the cardiac tissues from both sheep breeds, and carried out interaction analysis of the differentially expressed genes (DEGs) with rumen microbiota, VFAs, and metabolites. The results showed that: A total of 616 DEGs (P<0.05) were identified in the cardiac of sheep of different breeds, among which 437 genes were up-regulated and 179 genes were down-regulated. By comparing with known transcription factors, it was found that genes highly expressed in Hu sheep, such as ATP2A3, NPPB, PDE3A, SLC25A4, and AKT3, were significantly enriched in the cGMP-PKG signaling pathway. In the study of the interaction between rumen microbial genera and cardiac-related DEGs, it was found that microbial genera such as Candidatus Saccharimonas and Succiniclasticum had a close positive correlation (P<0.05) with genes related to cardiac energy metabolism. Analysis of the interaction between genes and VFAs showed that acetic acid, propionic acid, butyric acid, and valeric acid play roles in regulating gene expression. WGCNA revealed that different metabolite modules were concentrated and enriched in Metabolic pathways, participating in cardiac energy metabolism. Metabolites such as Arachidonate, Adenine, and 6-Keto-prostaglandin F1alpha, together with SLC25A4 and AKT3, are involved in regulating cardiac energy metabolism. This study revealed that Hu sheep may regulate cardiac metabolism through rumen microbes and metabolites to cope with high-altitude hypoxic stress, providing a certain reference for understanding the response of Hu sheep to the high-altitude hypoxic environment. - Source: PubMed
Publication date: 2025/11/18
Chen QianlingYang WenxinSha YuzhuLiu XiuChen XiaoweiHuang WeiHe YapengGao XuXu JianfengHe Jianwen - Regulatory T (T) cells expand during Mycobacterium tuberculosis (Mtb) infection and suppress T cell-mediated control. Whether Mtb actively contributes to this process is unclear. Here, using a genome-wide mutant library, we show that the expression of Mtb Rv1272c, an ATP-binding cassette transporter, increased under hypoxic conditions and promotes Mtb survival in vivo by increasing lecithin import, followed by the production and release of linoleic acid. Linoleic acid released by infected macrophages promoted surface trafficking of the immune checkpoint molecule cytotoxic T lymphocyte antigen 4 (CTLA-4) in T cells via the Ca²⁺ transporter ATP2a3. This in turn inhibited macrophage reactive oxygen species production and promoted Mtb survival inside macrophages. Rv1272c-induced linoleic acid further promoted Mtb immune evasion by increasing CTLA-4 surface trafficking on T cells in vivo. Mechanistically, linoleic acid interacts with ATP2a3 in T cells and promotes mitochondria-associated endoplasmic reticulum (ER) membrane formation. This facilitates ER-to-mitochondria Ca transfer and depletion of Ca in the ER, and triggers store-operated calcium entry, thus elevating cytosolic Ca levels to increase Ca-dependent CTLA-4 surface trafficking in T cells. These findings reveal that Mtb can use a metabolite to manipulate host responses and promote its intracellular survival. - Source: PubMed
Publication date: 2025/10/10
Cheng HongyuLi ShenzhiLiu HongjieYan MeiyiWang JingxiangHuang JingpingLiu ShanshanYang YifanCao XinyuCui PengfeiCheng YuannaLiu ZhonghuaWang JieHuang XiaochenWang LinQin LianhuaZheng RuijuanFeng Carl GZou QiangSun YichengJi ZheYang HuaGe Baoxue