Ask about this productRelated genes to: GOLGB1 antibody
- Gene:
- GOLGB1 NIH gene
- Name:
- golgin B1
- Previous symbol:
- -
- Synonyms:
- GCP, GCP372, giantin, GOLIM1
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-05
- Date modifiied:
- 2016-10-05
Related products to: GOLGB1 antibody
Related articles to: GOLGB1 antibody
- Alternative splicing (AS) is increasingly recognized as a hallmark of cancer, contributing to tumor progression and therapeutic resistance. Zinc finger MYND-type containing 11 (ZMYND11), a critical reader of the histone modification H3.3K36me3, is frequently downregulated in various cancers. However, its specific role in regulating AS in prostate cancer (PCa) remains unclear. This study aimed to elucidate the mechanisms by which ZMYND11 modulates AS in PCa and evaluate its potential as a therapeutic target. - Source: PubMed
Publication date: 2025/02/14
Lian ChengWang ZixianGao XuWei Gong-Hong - Intervertebral disc degeneration (IDD) is a multifactorially regulated age-related condition. Golgin B1 (GOLGB1) is a large Golgi-related transmembrane protein encoded by golgb1 gene. Since its discovery, GOLGB1 has been proved to be related to many diseases. However, its role in IDD is still unclear. The aim of this research was to examine whether GOLGB1 deficiency accelerates disc degeneration and to study its mechanism. We selected C57BL/6 male mice aged 8 weeks to isolate, culture and identify nucleus pulposus (NP) cells, and used a variety of experimental techniques, including plasmid transfection, western blotting (WB), real-time fluorescence quantitative PCR (RT-qPCR), EdU staining, Tunnel staining, CCK8 and flow cytometry (FCM) to detect the effects of GOLGB1 on the degeneration, proliferation and apoptosis of NP cells in vitro. Then, 8-week-old C57BL/6 male mice were selected for caudal vertebra acupuncture to establish IDD model, and the role and mechanism of GOLGB1 in the development of IDD were studied by HE staining, Safranin O-Fast Green staining, Alcian Blue staining and immunohistochemistry (IHC) staining. Our results demonstrated lower expression of GOLGB1 in human tissues with NP degeneration. Additionally, GOLGB1 expression was reduced in NP tissue from aging adult mice and IDD model mice. We further verified that GOLGB1 knockdown worsened NP cell degeneration, disturbed the composition of the extracellular matrix (ECM), and upset the harmony between anabolism and catabolism. Moreover, GOLGB1 knockdown inhibited the proliferation of NP cells and increased the apoptosis of NP cells. Mechanistically, GOLGB1 knockdown elevated p-ERK and p-P38 levels and activated the MAPK pathway. A MAPK signaling pathway inhibitor (SCH772984) strongly reversed this phenomenon and rescued the degeneration of NP cells. These findings suggest that GOLGB1 may be a potential new target for IDD. GOLGB1 is a protective factor against disc degeneration, and knockdown of GOLGB1 accelerates IDD by activating the MAPK pathway. - Source: PubMed
Publication date: 2026/01/17
Tian JingyuanWang ZhiquanLiu RuxingQiu XiaotingHe DongqinShan NanLi QichaoHe GuanghuiZhao BinYuan JieWang Yongfeng - Dilated cardiomyopathy (DCM) is a severe form of cardiomyopathy. The study aims to investigate the impact of metabolic and lifestyle factors on DCM and to identify new potential therapeutic targets. - Source: PubMed
Publication date: 2025/12/30
Wang HuiWang YihuiHuang DezhiJiang XiaoLi CaiyunXia XutingLiu GuichunShi JianchenLi Xinhui - Emerging evidence suggests that aberrant alternative splicing plays a vital role in the development of tumors. However, the expression of splicing factors (SF) in colorectal cancer and its relationship with prognosis is still unclear. Here, we divided patients into high-risk and low-risk groups through univariate COX analysis and LASSO regression analysis, and selected 13 alternative splicing factors that are highly correlated with prognosis for subsequent analysis. We systematically analyzed the prognostic value of transcription levels of SFs in colorectal cancer (CRC) and found that RAB3A interacting protein (RAB3IP), programmed cell death 4 (PDCD4), golgin B1 (GOLGB1), and neuregulin 4 (NRG4) as the most predictive markers for the prognosis of CRC. After comparing the expression of four splicing factors in cancer tissues with normal tissues as well as OS analysis, it is strongly indicated that only RAB3IP demonstrates a significant positive correlation with favorable prognosis. Accordingly, we established a risk signature of transcription levels of RAB3IP as an independent prognostic marker for CRC. Moreover, by the Gene Set Enrichment Analysis (GSEA), we demonstrated that the RAB3IP was correlated to Cell Cycle, WNT pathway and Spliceosome in cancer. In conclusion, our findings demonstrate that SFs play a critical role in CRC pathogenesis, and identify RAB3IP as a novel prognostic biomarker for CRC. - Source: PubMed
Publication date: 2025/06/23
Zhou ZhengweiGao FeiLei HanWen HaixuanTang JiaxiPeng YulongFan LiliXu LuShu Guang - Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vascular remodeling and involves Endothelial-to-Mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs). EndMT is a complex cell differentiation process, mainly showing the detachment of endothelial cell migration and reducing endothelial cell characteristics to varying degrees, acquiring mesenchymal cell characteristics. In addition, numerous studies have reported that eIF3a over expression plays an important role in the occurrence and development of fibrotic diseases, cancer, and degenerative lesions, however, the mechanisms of eIF3a affecting the dysfunction of pulmonary arterial endothelial cells remains largely unknown. Therefore, we aimed to demonstrate the underlying mechanisms of eIF3a-knockdown inhibiting EndMT by regulating TGFβ1/SMAD signal pathway in PAH. - Source: PubMed
Publication date: 2025/05/09
Jiao QiuhongXu XiufengXu LongwuWang YuyingPang ShulanHao JieLiu XiaohongZhao YudanQi WanpengQin LiminHuang TaoLi JingtianWang Tao