Ask about this productRelated genes to: KIAA1754L antibody
- Gene:
- ITPRIPL1 NIH gene
- Name:
- ITPRIP like 1
- Previous symbol:
- KIAA1754L
- Synonyms:
- -
- Chromosome:
- 2q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-03-12
- Date modifiied:
- 2017-09-15
Related products to: KIAA1754L antibody
Related articles to: KIAA1754L antibody
- Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1) has been identified as an inhibitory ligand of CD3ε, but its role in stomach adenocarcinoma (STAD) remains unclear. - Source: PubMed
Publication date: 2025/12/09
Jia ZixuanXiong KangqiaoZhou YouChen RongWang DaofengCai ShaohangLiao Wei - CD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacterized. This study aimed to evaluate CD3L1 expression in osteosarcoma and chordoma and assess its association with clinical features and outcomes. Formalin-fixed, paraffin-embedded tissue samples from 42 osteosarcoma and 20 chordoma patients were analyzed for CD3L1 expression using immunohistochemistry. Multiplex immunofluorescence staining was performed to evaluate immune cell infiltration in chordoma. Associations between CD3L1 expression and clinicopathological parameters were examined using chi-square tests, Fisher's exact test, and Kaplan-Meier survival analysis. CD3L1 was detected in 62.9% (39/62) of cases, with positivity rates of 59.6% in osteosarcoma and 70.0% in chordoma. CD3L1 expression was independent of patient age, sex, or tumor location but was significantly associated with chondroid stroma and prior PD-1 immunotherapy in osteosarcoma. In chordoma, higher CD3L1 expression correlated with increased infiltration of CD8 T cells, B cells, and M2 macrophages. CD3L1 is expressed in osteosarcoma and chordoma and is associated with features of the tumor immune microenvironment, including markers of macrophage infiltration. As a potential therapeutic target, CD3L1 warrants further functional and clinical investigation. - Source: PubMed
Publication date: 2025/11/26
Wang YuhangXu JiuhuiDeng ShouyanSun KunkunWang YaqiRen TingtingTang XiaodongXu JieXie Lu - Gastric cancer (GC), originating from gastric mucosa epithelial cells, is a global health issue, ranking as the fifth most common cancer and fourth in cancer-related deaths. Stomach adenocarcinoma (STAD) accounts for 95% of GC cases. Emerging evidence suggests a link between manganese (Mn) metabolism and GC, but the role of Mn metabolism-related genes (MMRGs) in STAD is unclear. This study aims to bridge this gap of Mn metabolism through the development of a robust prognostic signature derived from The Cancer Genome Atlas (TCGA) data. - Source: PubMed
Publication date: 2025/10/22
Li DouWei DanLi LianyongZhong ChangqingBao XinweiZhang WenjuanSui Xinke - The aberrant expression of AARS1 has been linked to tumor progression in various cancers. However, its role and underlying mechanisms in head and neck squamous cell carcinoma (HNSCC) remain unclear. - Source: PubMed
Publication date: 2025/09/08
Chen ShengkaiYou YuanheZhu FangxingZhang ZhiyuanShi JianboTian Zhuowei - Glioma represent one of the most prevalent and lethal malignancies within the central nervous system. Recent studies have identified ITPRIPL1, a newly reported CD3ε-inhibitory ligand, as a suppressor of T cell activation, thereby facilitating tumor immune evasion and offering a novel avenue for immunotherapeutic intervention in glioma. - Source: PubMed
Xiaoyun ZouWenhao YeHuan WuYuanyuan YangChangqing LiuHebao WenCaiyun Ma