Ask about this productRelated genes to: SLC23A3 antibody
- Gene:
- SLC23A3 NIH gene
- Name:
- solute carrier family 23 member 3
- Previous symbol:
- -
- Synonyms:
- SVCT3, FLJ31168, Yspl1
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-17
- Date modifiied:
- 2015-12-08
Related products to: SLC23A3 antibody
Related articles to: SLC23A3 antibody
- Type 2 diabetes (T2D) is a complex metabolic disorder strongly influenced by genetics. Most genetic studies, including expression quantitative trait loci (eQTL) analyses, use bulk pancreatic tissue, masking cell-specific mechanisms. Here, by integrating single-cell RNA sequencing, chromatin accessibility, and genome-wide association studies (GWAS) data, we systematically identified 328 pancreatic cell-type-specific cis-eQTLs associated with T2D. We pinpointed nine key genes (including STIL in beta and delta cells; ZSWIM5 in alpha, delta, and ductal cells; IL1RN, ANP32E, IPP, MLLT11, and SLC23A3 in delta cells; SNX4 in gamma cells; and RBMS1 in beta cells) whose SNPs overlapped with chromatin accessibility peaks. These genes highlight regulatory pathways in beta-cell dysfunction, metabolic stress responses, and disrupted pancreatic homeostasis. A public database, CTPeQTLs (https://ctpeqtls.netlify.app/), was developed to explore cis-eQTLs across diabetic and non-diabetic cohorts, revealing distinct regulatory patterns in both endocrine and exocrine cells, as well as disease-associated transcriptional dysregulation. Our findings uncover cell-specific genetic mechanisms in diabetes and provide potential therapeutic targets, supporting precision medicine strategies. - Source: PubMed
Miao Xiao-CaoLi HuiLi QingZhu LeiYu Yan-QiuJi Jian-GuangChen TaoZhang Zhi-GangLi Dong-Xue - LLC-PK1 renal cells show Na-dependent and Na-independent hypoxanthine uptake. While the latter is inhibited by adenine, neither are inhibited by xanthine. In rats, intestinal Na-dependent hypoxanthine transporter Slc23a4 is not expressed in the kidney, and its action is inhibited by xanthine. This study aimed to clone -paralog from the human kidney and investigate its hypoxanthine transport activity. We observed Na-dependent 10 nM [H]-hypoxanthine uptake in RNA-injected oocytes. Moreover, 100 μM xanthine did not inhibit Na-independent 300 nM [H]-hypoxanthine uptake, whereas 100 μM adenine did. These results confirm that SLC23A3 is a hypoxanthine transporter in the human kidney. - Source: PubMed
Publication date: 2022/01/30
Hosoyamada MakotoTomioka Naoko HWatanabe TamakiYasuno NobuhiroUchida ShunyaShibata Shigeru - Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. - Source: PubMed
Publication date: 2020/11/17
Zheng Ju-ShengLuan Jian'anSofianopoulou EleniImamura FumiakiStewart Isobel DDay Felix RPietzner MaikWheeler EleanorLotta Luca AGundersen Thomas EAmiano PilarArdanaz EvaChirlaque María-DoloresFagherazzi GuyFranks Paul WKaaks RudolfLaouali NasserMancini Francesca RomanaNilsson Peter MOnland-Moret N CharlotteOlsen AnjaOvervad KimPanico SalvatorePalli DomenicoRicceri FulvioRolandsson OlovSpijkerman Annemieke M WSánchez María-JoséSchulze Matthias BSala NúriaSieri SabinaTjønneland AnneTumino Rosariovan der Schouw Yvonne TWeiderpass ElisabeteRiboli ElioDanesh JohnButterworth Adam SSharp Stephen JLangenberg ClaudiaForouhi Nita GWareham Nicholas J - Osteoporosis (OP) is a multi-factorial bone disease influenced by genetic factors, age, and lifestyles. The aim of this study is to evaluate the genetic correlations between OP and multiple lifestyle-related factors, and explore the genes underlying the detected genetic correlations. Linkage disequilibrium score regression (LDSC) analysis was applied to evaluate the genetic correlations of total body bone mineral density (TB-BMD) of different ages (including 15-30 years, 30-45 years, 45-60 years, and over 60 years) with four common lifestyle/environment-related factors (including serum 25-hydroxyvitamin D, cigarette smoking, alcohol dependence, and caffeine metabolites). Transcriptome-wide association studies (TWAS) of TB-BMD (30-45 years) and smoking were conducted in peripheral blood (PB), whole blood (WB), and adipose tissues. The identified candidate genes were also subjected to gene set enrichment analysis (GSEA). Genetic correlation was only observed between TB-BMD (30-45 years) and cigarette smoking status (P = 0.01, LD score = 0.11 ± 0.04). No significant genetic correlation was detected for other lifestyle/environmental factors, including serum 25-hydroxyvitamin D, alcohol dependence, and caffeine metabolites for TB-BMD within all of the four age groups. TWAS identified 85 genes in PB and 163 genes in WB for TB-BMD, as well as 123 genes in PB and 257 genes in WB for smoking. Multiple common candidate genes shared by both TB-BMD and smoking were detected, such as MAP1LC3B (P = 1.00 × 10, P = 9.62 × 10, P = 2.99 × 10) and SLC23A3 (P = 1.48 × 10, P = 8.76 × 10). GSEA detected one GO terms for TB-BMD (cytosol) in WB, one GO term for smoking (mitochondrion) in PB, and one pathway (oocyte meiosis) for smoking in WB. - Source: PubMed
Publication date: 2019/12/12
Du YananLi PingWen YanLiang XiaoLiu LiCheng BolunDing MiaoZhao YanMa MeiZhang LuCheng ShiqiangGuo XiongZhang Feng - Drug bioavailability studies commonly employ in vitro barrier tissue models consisting of epithelial and endothelial cells. These experiments require that the cell barrier quality be assessed regularly, which is usually performed using various labeled substrates and/or evaluation of transepithelial (transendothelial) electrical resistance (TEER). This technique provides information on the integrity of the monolayer, but not on differentiation-induced changes in the cell morphology. The present work shows that impedance spectroscopy can be applied to monitor both the integrity of the monolayer and the morphological changes of Caco-2 cells. The growth kinetics of the apical membrane was determined by calculating the electrical capacitance of the cell monolayer. In the course of differentiation, the most pronounced changes in the expression levels were observed for the mRNAs that encode SLC30A10 and SLC23A3 transporters. Their increase correlated with an increase in the apical membrane area, indicating that SLC30A10 and SLC23A3 mRNA levels assessed by qRT-PCR may be employed as cell differentiation biomarkers in Caco-2 models. - Source: PubMed
Nikulin S VKnyazev E NPoloznikov A AShilin S AGazizov I NZakharova G SGerasimenko T N