Ask about this productRelated genes to: OR2W5 antibody
- Gene:
- OR2W5 NIH gene
- Name:
- olfactory receptor family 2 subfamily W member 5 (gene/pseudogene)
- Previous symbol:
- OR2W5P
- Synonyms:
- OST722
- Chromosome:
- 1q44
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-28
- Date modifiied:
- 2017-12-04
Related products to: OR2W5 antibody
Related articles to: OR2W5 antibody
- Malignant pleural mesothelioma (MPM), a rare cancer a long latency period (up to 40 years) between asbestos exposure and disease presentation. The mechanisms coupling asbestos to recurrent somatic alterations are poorly defined. Gene fusions arising through genomic instability may create novel drivers during early MPM evolution. We explored the gene fusions that occurred early in the evolutionary history of the tumor. We conducted multiregional whole exome sequencing (WES) of 106 samples from 20 patients undergoing pleurectomy decortication and identified 24 clonal nonrecurrent gene fusions, three of which were novel (FMO9P-OR2W5, GBA3, and SP9). The number of early gene fusion events detected varied from zero to eight per tumor, and presence of gene fusions was associated with clonal losses involving the Hippo pathway genes and homologous recombination DNA repair genes. Fusions involved known tumor suppressors BAP1, MTAP, and LRP1B, and a clonal oncogenic fusion involving CACNA1D-ERC2, PARD3B-NT5DC2, and STAB2-NT5DC2 fusions were also identified as clonal fusions. Gene fusions events occur early during MPM evolution. Individual fusions are rare as no recurrent truncal fusions event were found. This suggests the importance of early disruption of these pathways in generating genomic rearrangements resulting in potentially oncogenic gene fusions. - Source: PubMed
Publication date: 2023/07/08
Jama MaymunZhang MinPoile CharlotteNakas ApostolosSharkey AnnabelDzialo JoannaDawson AlanKutywayo KudazyiFennell Dean AHollox Edward J - Once considered nonfunctional, pseudogene transcripts are now known to provide valuable information for cancer susceptibility, including head and neck cancer (HNC), a serious health problem worldwide, with about 50% unimproved overall survival over the last decades. The present review focuses on the role of pseudogene transcripts involved in HNC risk and prognosis. We combined current literature and analyses from The Cancer Genome Atlas (TCGA) database to identify the most deregulated pseudogene transcripts in HNC and their genetic variations. We then built a co-expression network and performed gene ontology enrichment analysis to better understand the pseudogenes' interactions and pathways in HNC. In the literature, few pseudogenes have been studied in HNC. Our analysis identified 370 pseudogene transcripts associated with HNC, where , , , , , , , , and were found to be the most deregulated and presented several genetic alterations. , , and pseudogenes were predicted to interact with 12 genes known to participate in HNC, was predicted to interact with the gene, and pseudogene was predicted to interact with and genes. The identified pseudogenes were associated with cancer biology pathways involving cell communication, response to stress, cell death, regulation of the immune system, regulation of gene expression, and Wnt signaling. Finally, we assessed the prognostic values of the pseudogenes with the Kaplan-Meier Plotter database, and found that expression of , , , , and pseudogenes were associated with patients' survival. Due to pseudogene transcripts' potential for cancer diagnosis, progression, and as therapeutic targets, our study can guide new research to HNC understanding and development of new target therapies. - Source: PubMed
Publication date: 2021/08/17
Carron JulianaDella Coletta RafaelLourenço Gustavo Jacob