Ask about this productRelated genes to: SECTM1 antibody
- Gene:
- SECTM1 NIH gene
- Name:
- secreted and transmembrane 1
- Previous symbol:
- -
- Synonyms:
- K12
- Chromosome:
- 17q25
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-27
- Date modifiied:
- 2008-07-18
Related products to: SECTM1 antibody
Related articles to: SECTM1 antibody
- Polycystic ovary syndrome (PCOS) is a heterogeneous disorder with incompletely understood epigenetic regulation. We investigated the role of N6-methyladenosine (m6A)-related single nucleotide polymorphisms (m6A-SNPs) in PCOS. - Source: PubMed
Publication date: 2026/04/11
Jin MengqiXi SujuanMa Lin - Type 2 diabetes mellitus (T2DM) significantly elevates the risk of tuberculosis (TB); however, early detection in T2DM patients is still insufficient. This study aimed to identify immune-based early-warning biomarkers, develop robust prognostic models, and elucidate the immune-metabolic circuitry underlying the comorbidity of type 2 diabetes and tuberculosis (T2DM-TB). - Source: PubMed
Publication date: 2026/02/26
Ye ZhaoyangBai GuangliangCheng PengPeng CongYang LingZhuang LiLi LinshengLi YufengNi RuiziZhou ShuangAn YajingZhang MingmingTian YuanWang LiangGong Wenping - This study aimed to investigate the expression of cluster of differentiation 7 (CD7) in hepatoblastoma (HB) and its potential use as a novel biomarker of HB. - Source: PubMed
Publication date: 2025/12/04
Adawy AhmadYoshii DaikiHirao HirokiKomohara YoshihiroFujiwara YukioTomita MasahiroHonda MasakiHan JiaLiu YaoYamada SohsukeYamamoto MasahiroHiyama EisoHibi Taizo - The adenoma-adenocarcinoma pathway represents a crucial mechanism underlying the development of colorectal precancerous lesions, encompassing approximately 85%-90% of colorectal cancer (CRC). Elucidating the molecular mechanisms underlying colorectal cancer progression is of paramount importance for achieving early and accurate diagnosis as well as effective treatment. We collected peripheral blood mononuclear cells (PBMC) from healthy controls, adenoma patients, and adenocarcinoma patients, and performed transcriptomic profiling to characterize dynamic gene expression during carcinogenesis. Diagnostic potential was assessed using receiver operating characteristic (ROC) analysis, and a random-forest model was trained to classify disease status. The screening identified genes with consistent expression changes as potential early diagnostic markers, and further exploration of their functions and significance in CRC is conducted through analysis of the TCGA database. The findings revealed that the progression of precancerous lesions in the "Normal-Adenoma-Cancer" (N-A-C) sequence was accompanied by a sustained enhancement of the immune response. Notably, HECW2, WARS1, SLC16A3, SECTM1, IFITM3, ADAMTSL4, FCGR1A, F2RL1, OPLAH, SERPINA1, FCGR1CP showed consistent upregulation with promising diagnostic performance. In our PBMC cohort, the random-forest classifier achieved an accuracy of 93.62%, indicating potential for distinguishing cancer from precancerous lesions. The bioinformatics analysis revealed a significant association of these genes with DNA methyltransferase, DNA mismatch repair, m6A regulator, tumor mutational burden (TMB) and microsatellite instability (MSI). Furthermore, a detailed analysis was further performed on WARS1. In the "N-A-C" sequence, WARS1 exhibited a significant upregulation in both blood and tissues, demonstrating a positive correlation with augmented infiltration of immune cells, activation of stromal and immune responses, as well as heightened activity during the cancer immune cycle. However, it demonstrates a declining trend in the progression of CRC from stage I to IV, which may be intricately associated with the metastasis of CRC. The WARS1 can serve as a reliable indicator of the immune response in CRC, thereby demonstrating its potential to impede tumorigenesis or metastasis. - Source: PubMed
Publication date: 2025/10/27
Zhou BingwenLiu QingruiHuang ChuyueChen HaoWang PeiLu YueyangJiang ShujunKong DesongWang LuFan Zhimin - Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SECTM1), a monocyte chemoattractant, to be our top novel finding associated with incident CHD. We validated our findings in the Cardiovascular Health Study. The top variant (rs116473040) associated with SECTM1 was associated with circulating monocyte percentage of white blood cells in a genomic database. In vivo studies demonstrated that recombinant SECTM1a increased the proportion of proatherogenic Ly6Chi monocytes, suggesting a pathway by which SECTM1 may contribute to CHD. - Source: PubMed
Publication date: 2025/09/16
Tahir Usman ACruz DanielShen DongxiaoTiwari GauravLiu JingHuber MatthewChan ChristopherDeng ShuliangBenson Mark DRobbins JeremyChen Zsu ZsuFarrell LaurieEkunwe LynetteHall MichaelPsaty Bruce MFloyd James SAsnani AartiSwirski Filip KWilson James GGerszten Robert E