Ask about this productRelated genes to: MLSTD1 antibody
- Gene:
- FAR2 NIH gene
- Name:
- fatty acyl-CoA reductase 2
- Previous symbol:
- MLSTD1
- Synonyms:
- FLJ10462, SDR10E2
- Chromosome:
- 12p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-01
- Date modifiied:
- 2016-10-05
Related products to: MLSTD1 antibody
Related articles to: MLSTD1 antibody
- This study aimed to identify inflammatory subtypes of asthma using peripheral blood transcriptomics and to derive candidate biomarkers supported by multi-level validation. - Source: PubMed
Publication date: 2026/03/13
Zhou XiaofeiChen YuhuiHui Yu - Wax esters (WEs) are lipids characteristic of sebaceous glands and are classified into wax monoesters (WmEs) and wax diesters (WdiEs). Here, we analyzed WEs in mouse sebum via liquid chromatography-tandem mass spectrometry to characterize their composition and structural diversity. We found that mouse sebum contained type 2α and type 2ω WdiEs and revealed the detailed species composition of these WdiEs together with WmEs. In knockout mice of the acyl-CoA reductase , the quantities of WEs with very-long-chain fatty alcohols were reduced relative to wild-type mice. In knockout mice of the acyl-CoA wax alcohol acyltransferase , the quantities of many WmEs and type 2ω WdiEs containing long-chain fatty acids were decreased. Sebum WEs were substantially more diverse than meibum WEs. These findings reveal that mouse sebum contains WEs comprising a variety of fatty acids and fatty alcohols and provide clues to the molecular mechanism of their production. - Source: PubMed
Publication date: 2026/01/29
Kuribayashi KarinJojima KeisukeYamamoto MoeTakeda MireiKihara Akio - To investigate the associations between fibrinogen to albumin ratio (FAR) and remote diffusion-weighted imaging lesions (RDWILs) as well as 1-month short-term outcomes in patients with acute intracerebral hemorrhage (ICH). - Source: PubMed
Publication date: 2025/09/23
Zhu YutingZhang TengWang YinggeXu Xiaotian - Mammalian cell membranes contain ether lipids, which include an alkyl chain derived from a fatty alcohol that is produced by fatty acyl-CoA reductases (FARs). There are two mammalian FAR genes, and , and mutations in cause the peroxisomal fatty acyl-CoA reductase 1 disorder (PFCRD), which is accompanied by various symptoms, including neurological disorders. To date, the contributions of and to brain ether lipid production and the molecular mechanism of PFCRD have remained unknown. To investigate these, we analyzed knockout (KO) mice of and . In the brain, the expression levels of were higher than those of , and was widely expressed. Lipidomic analyses showed that the quantity of ether lipids ethanolamine-plasmalogens was reduced in KO mice, with a complementary increase in diacyl-type phosphatidylethanolamines, but not in KO mice. Electron microscope analysis of the corpus callosum revealed reductions in the percentage of myelinated axons and myelin thickness in KO mice relative to WT mice. In conclusion, FAR1 is the major FAR isozyme involved in ether lipid synthesis in the brain, and its deficiency causes hypomyelination. We speculate that this hypomyelination is one of the causes of the neurological symptoms of PFCRD. - Source: PubMed
Publication date: 2025/09/11
Takahashi TengaOtsuka KentoSassa TakayukiKihara Akio - Seminolipids are testis-specific ether glycolipids that are important for spermatogenesis. The fatty alcohol (ether-linked alkyl moiety) in ether lipids is generated from an acyl-CoA by fatty acyl-CoA reductase (FAR). To date, the diversity of the alkyl and acyl moieties in seminolipids, the specific stage of spermatogenesis during which seminolipids are produced, and the FAR isozyme (FAR1 or FAR2) involved in the synthesis of the alkyl moieties have remained largely unclear. Here, we demonstrated that Far1 is expressed in the mouse testis via quantitative RT-PCR analysis, whereas Far2 was barely detectable. In situ hybridization and quantitative RT-PCR analysis of spermatogenic cells separated via FACS revealed that Far1 is expressed in spermatogonia, spermatocytes, and spermatids. We generated Far1 KO mice and found that male Far1 KO mice were infertile. In these mice, sperms were absent in the epididymides and the testes were small, with multinucleated cells and vacuoles in the seminiferous tubules. LC-MS/MS analysis showed that the vast majority of seminolipids (>90%) in WT mouse testes contained C16:0 in both the alkyl and the acyl moieties. Seminolipids were present in all subclasses of spermatogenic cells in WT mice, but they were absent in Far1 KO mice. Instead, the production of nonether, diacyl-type sulfogalactosyl lipids (sulfogalactosyl diacylglycerols) was induced in Far1 KO mice. In conclusion, the alkyl and acyl moieties of seminolipids in the testis are low in diversity, and Far1 is essential for seminolipid synthesis and spermatogenesis. - Source: PubMed
Publication date: 2025/04/25
Tamazawa AyanoNaganuma TatsuroOtsuka KentoTakahashi TengaSassa TakayukiKihara Akio