Ask about this productRelated genes to: FURIN antibody
- Gene:
- FURIN NIH gene
- Name:
- furin, paired basic amino acid cleaving enzyme
- Previous symbol:
- PCSK3, FUR, PACE
- Synonyms:
- SPC1
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-08
- Date modifiied:
- 2016-02-22
Related products to: FURIN antibody
Related articles to: FURIN antibody
- Lipoprotein lipase (LPL) is the rate-limiting enzyme that hydrolyzes triglycerides within circulating lipoproteins. LPL dysfunction leads to familial LPL deficiency, which is characterized by chylomicronemia and high risk for acute pancreatitis. Although cell culture studies indicate that the protease furin inactivates LPL by cleavage, the physiological relevance of this process remains unclear. In this study, we investigated the impact of furin-mediated LPL cleavage in vivo using inducible knockout mouse models and gene therapy. After identifying the tissue-specific prevalence of LPL cleavage, we compared mice expressing a furin-resistant LPL mutant versus furin-sensitive LPL. Our results demonstrate that furin-resistant LPL lowers longitudinal plasma triglyceride levels without causing adverse effects such as hepatic steatosis. These findings highlight that engineered furin resistance is a viable strategy to enhance LPL's metabolic function. - Source: PubMed
Publication date: 2026/05/21
Wu Ming JingYang ChelseaWu SiruiDevlin GarthLin Feng-ChangAsokan AravindNeher Saskia B - Longitudinal proteomic studies on hypertension remain scarce. We evaluated the epidemiological associations of circulating proteins with hypertension on the basis of the UK Biobank (UKB) and public GWAS-summary data in this study. - Source: PubMed
Publication date: 2026/05/08
Zhang HongruiLiang ZhuoshuaiHu XinmengJin HuizhenZhang YuanWang JiaheYu BowenTian YuyangQiu ShuangLi YongGu YuluLiu YunkaiCheng YiShi JikangLiu Yawen - Newcastle disease virus (NDV) infects a wide range of hosts, including poultry and wild birds. However, most research has focused on poultry-derived strains, with limited studies on the biological characteristics of NDV isolated from wild birds. This study investigated genotype IX NDV strains from wild birds. Genetic evolution and viral ecology analyses suggest possible poultry-to-wild-bird transmission of this genotype. Most of the genotype IX NDV strains, isolated from asymptomatic wild birds, were highly pathogenic in chickens, but one strain isolated from spotted dove exhibited attenuated virulence. This dove-derived strain showed the highest homology with a virulent strain from Eurasian blackbird, differing by only 12 amino acids across proteins. Using reverse genetics, we identified the viral HN protein as a critical determinant of virulence in the dove strain. The coexistence of F110 and G116 residues in the HN protein was associated with reduced HN cell-surface abundance and downstream decreases in viral membrane fusion activity, replication capacity, and tissue tropism. Computational modeling further suggests that the F110/G116 combination may be linked to a local α-helix within the HN head-stalk linker region, providing a plausible structural context for these effects. Crucially, this dove strain's fusion protein retained the furin-cleavable, virulent-type "¹¹²RRQRRF¹¹⁷" cleavage site. Immunizing chickens with this strain induced high antibody titers within 1 week, and titers persisted at high levels for 13 weeks and provided complete protection against virulent challenge at both early and late post-immunization time points. Our findings uncover an HN-linked attenuation mechanism centered on residues 110 and 116, primarily through their effects on HN cell-surface abundance and downstream fusion activity, offering new insights into the development of immunogenic NDV vaccines with reduced virulence.IMPORTANCEWild birds, as natural reservoirs of Newcastle disease virus (NDV), harbor a diverse range of viral strains. However, research on these strains remains limited. Here, we show that genotype IX NDV detected in wild birds most likely reflects possible poultry-to-wild bird transmission rather than long-term endemic circulation in wild populations. Using isolates derived from wild birds, we report a novel attenuation mechanism involving structural modification of the HN protein's head-neck linker region. Therefore, research on wild bird-derived isolates not only provides insights into the epidemiological dynamics of NDV transmission but also facilitates the identification of novel attenuated strains, which could aid in the development of high-efficacy NDV vaccines and NDV-based viral vectors. - Source: PubMed
Publication date: 2026/05/20
Lu KejiaTong LinaDaguia-Wenam Prince-TheodoreChang ZhengwuXiao SaYang ZengqiLiu Haijin - Childhood pulmonary TB diagnosis remains a challenge due to difficulties in obtaining suitable specimens and the paucibacillary nature of the disease. Recent advances in sample collection and diagnostics could improve care for children, especially those with rifampicin-resistant TB (RR-TB). Although these have been recommended by the WHO, there have been limited reporting of the clinical impact of these novel approaches. We report the clinical impact of stool sampling in four children at Karonga District Hospital in Malawi. All four children were diagnosed with RR-TB, received all-oral regimens, and experienced successful treatment outcomes. - Source: PubMed
Publication date: 2026/05/18
Chitsulo SOmotayo DFurin JSaidi YChisale MMbakaya BSinyiza FMwenyenkulu T - Postprandial variability in glucose and protein levels is one of the elements of insulin resistance (IR) and prediabetes, which is an area precursor to type 2 diabetes mellitus (DM). The objective of the study was a comprehensive proteomic analysis according to glucose tolerance in the general population who did not self-report DM or other diseases. We used Olink Reveal, a novel, high-throughput platform by Olink Proteomics based on their Proximity Extension Assay (PEA), to identify levels of 1034 circulating proteins in small volumes (4 µL) of plasma samples. The study enrolled 508 participants (mean age 52 ± 10.5 years, 47.2% men) from the population-based study, Bialystok PLUS Polish Longitudinal University Study. The study population was categorized according to glucose metabolism in comparison to impaired fasting blood glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed DM. Analysis of variance (ANOVA) adjusted for age, weight, fat mass, lean mass, and body mass index (BMI), identified 19 proteins significantly associated with categories of glucose tolerance. Of the five markers with the greatest ability to distinguish newly diagnosed diabetes from non-diabetic participants, paralemmin 2 performed best (AUC = 0.81; 77% sensitivity, 75% specificity), whereas furin was the most accurate for detecting any abnormal glucose regulation (AUC = 0.69). A linear regression model adjusted for the same confounding factors showed statistically significant associations between Hb levels and 37 proteins. Our findings highlight multiple proteins with significantly different levels across categories of glucose tolerance, especially between the healthy controls and the group with newly diagnosed DM. The consistent patterns of protein level differences, independent of body composition, suggest potential involvement in the progression of glucose metabolism disturbances and provide unique insights into pathomechanisms. These findings identify PALM2, FURIN, PDZK1, ACAA1, and IL18R1 as potential biomarkers of early dysglycemia. - Source: PubMed
Publication date: 2026/04/26
Zieleniewska NataliaJamiołkowski JacekMalarstig AndersDiamanti KlevChlabicz MałgorzataKondraciuk MarcinWoo KerhanKowalska IrinaKamiński Karol