Ask about this productRelated genes to: ABCD2 antibody
- Gene:
- ABCD2 NIH gene
- Name:
- ATP binding cassette subfamily D member 2
- Previous symbol:
- ALDL1
- Synonyms:
- ALDR, ALDRP
- Chromosome:
- 12q12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-10
- Date modifiied:
- 2015-11-13
Related products to: ABCD2 antibody
Related articles to: ABCD2 antibody
- Acute dizziness accounts for approximately 4% of emergency department (ED) visits, with stroke often missed. Current methods for stroke detection in dizzy patients have notable limitations, with vestibular strokes missed in a substantial proportion of ED visits. This study aimed to develop a machine learning (ML) tool to assess stroke risk in patients with acute dizziness. - Source: PubMed
Publication date: 2026/03/24
Sung Sheng-FengHu Ya-Han - Transient ischemic attack (TIA) carries substantial short-term stroke risk, yet current diagnostics lack adequate sensitivity. Diffusion-weighted imaging (DWI) detects only 30% to 50% of TIA-related lesions, while 3-dimensional arterial spin labeling (3D-ASL) offers complementary hemodynamic assessment. We performed a retrospective cohort study of 106 TIA patients and 58 healthy controls undergoing 3.0T MRI within 72 hours of symptom onset. Imaging included DWI (b = 0,1000 seconds/mm2), 3D-ASL with dual post-labeling delays, and MR angiography. Clinical data and ABCD2 scores were collected, with 90-day stroke follow-up. Diagnostic performance and prognostic factors were analyzed using ROC curves and Cox regression. DWI detected acute lesions in 37 patients (34.9%), while 3D-ASL revealed cerebral hypoperfusion in 64 (60.4%), including 35 DWI-negative cases. Combined imaging improved 90-day stroke prediction (AUC 0.854; sensitivity 93.8%, specificity 71.1%) versus DWI alone (AUC 0.761) or 3D-ASL alone (AUC 0.790) (P <.05). During follow-up, 16 patients (15.1%) experienced stroke. Multivariate analysis identified DWI positivity (HR 3.24, 95% CI: 1.18-8.91), hypoperfusion volume >15 mL (HR 2.87, 95% CI: 1.06-7.78), and ABCD2 score ≥4 (HR 3.01, 95% CI: 1.09-8.31) as independent predictors. Symptom duration ≥1 hour correlated with higher DWI positivity (47.7% vs 25.8%, P = .012) and larger hypoperfusion volumes (16.8 vs 9.2 mL, P = .004). Combining 3D-ASL with DWI significantly improves cerebrovascular pathology detection and 90-day stroke risk prediction beyond clinical scoring, identifying high-risk TIA patients for intensified secondary prevention. - Source: PubMed
Fu YanmeiShang TongyuWang PeiqiPeng Chuan - Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group and estimate their population attributable fraction (PAF). - Source: PubMed
Publication date: 2026/03/18
Khan FaizanYogendrakumar VignanLun RondaMarx Caterina ERochwerg BramTran AlexandreFernando Shannon MGanesh AravindBarber Philip AÖgren JoachimOis AngelGiralt-Steinhauer EvaKhanevski Andrej NetlandLeng XinyiTian XuanLeung Thomas WVerburgt EsmeeVerhoeven Jamiede Leeuw Frank-ErikIldstad FredrikFandler-Höfler SimonAarnio Karoliinavon Sarnowski BettinaLorenzetti Diane LCoutts Shelagh BAmarenco PierreHankey Graeme JHill Michael D - Emamectin benzoate is a key insecticide for controlling Spodoptera frugiperda, a highly destructive agricultural pest. However, the emergence of resistance frequently results in control failures. Monitoring insecticide resistance in S. frugiperda populations and elucidating the underlying genetic mechanisms are essential for developing informed pest management decisions and effective resistance management strategies. This study demonstrates that six field populations of S. frugiperda from China have developed moderate resistance to emamectin benzoate, with resistance ratios (RR) ranging from 19.05- to 67.14. In a laboratory-selected emamectin benzoate-resistant strain (RR = 255.71), a high level of cross-resistance was observed between emamectin benzoate and abamectin (RR = 22.45), whereas only low levels of cross-resistance were detected for indoxacarb, lufenuron, chlorantraniliprole, deltamethrin, or cyantraniliprole (RR < 2.05). Synergism bioassays indicate that ATP-binding cassette (ABC) transporters may contribute to emamectin benzoate resistance. Integrated transcriptome sequencing and quantitative real-time PCR analyses reveal that ABCD2, ABCC2, ABCG20a, and ABCB1 are constitutively overexpressed in both the resistant strain and field-collected populations. RNA interference-mediated knockdown using dsRNAs targeting individual genes or a mixture of ABCD2, ABCC2, ABCG20a, and ABCB1 significantly increased the susceptibility of S. frugiperda to emamectin benzoate. Molecular docking studies demonstrate that emamectin benzoate directly binds to these ABC transporters, highlighting their potential role in metabolic resistance. In conclusion, this study clarifies the current status of emamectin benzoate resistance in S. frugiperda in China and identifies the contribution of four ABC transporters to resistance development. These findings provide a scientific foundation for the development of sustainable pest management and control strategies. - Source: PubMed
Publication date: 2026/01/27
Wang CongsaiWang ZikunLi JingdongZi YunkunHuang HuilingBai BinruiChen KeyiWang JingChen HongsongTan HuihuaMao Kaikai - The ABCD2 score is a validated risk stratification tool used to quantify the risk of stroke within 48 hours among patients presenting with suspected transient ischemic attack (TIA). Limited data exist regarding its performance among patients in an emergency department observation unit (EDOU). The objective of this study was to determine the safety and efficacy of the ABCD2 score in a US EDOU cohort. - Source: PubMed
Publication date: 2026/02/20
Lumia SalvatoreIobst WesleyKhan ZohayrSokolosky StephenHutchison Benjamin TGuzik AmyWittler Mary AReynolds Patrick SAshburn Nicklaus P