Ask about this productRelated genes to: PPAPDC1B antibody
- Gene:
- PLPP5 NIH gene
- Name:
- phospholipid phosphatase 5
- Previous symbol:
- PPAPDC1B
- Synonyms:
- HTPAP, DPPL1
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-15
- Date modifiied:
- 2016-10-05
Related products to: PPAPDC1B antibody
Related articles to: PPAPDC1B antibody
- The present study aimed to explore the mechanism by which quercetin alleviates E. coli K88-induced liver injury in broilers. A total of 240 one-day-old broilers were chosen and randomly divided into four groups: control, E. coli K88, aureomycin and quercetin groups with six replicates per group and 10 broilers per replicate. Broilers in control and E. coli K88 groups were fed a basal diet, broilers in aureomycin and quercetin groups were fed a basal diet supplemented with 75 mg/kg aureomycin and 750 mg/kg quercetin until 20 days of age, respectively. At the 21st day of age, broilers in E. coli K88, aureomycin and quercetin groups were treated by 2×10 CFU chicken E. coli K88 gavage, while those in control group were treated by sterile saline (equal volume with E. coli K88) gavage, feeding continued for three weeks. The mechanism of quercetin in alleviating E. coli K88-induced liver injury was explored by 16S rDNA sequencing, non-targeted metabolomics and transcriptomics. The present result showed that compared with E. coli K88 group, 1) Dietary quercetin and aureomycin alleviated E. coli K88-induced liver injury to varying degrees in broilers, and quercetin worked better than aureomycin; aureomycin and quercetin significantly decreased content of GGT, ALB, ALP, TBIL, ALT and ALB/GLB (P < 0.05). 2) Quercetin significantly decreased the abundance of Proteobacteria, and significantly increased the abundance of Actinobacteria and Fusobacteriota at phylum level (P < 0.05). 3)The transcriptomic and metabolomic results showed that quercetin significantly increased expression of PISD and MBOAT1 (P < 0.05), and significantly decreased expression of GPAT4, GPAT3, PCYT2, SELENOI, PLPP5, ADPRM, LCAT, LYPLA2 and CDS2 (P < 0.05); quercetin significantly increased the relative mabundance of Glycerol 3-phosphate, Glycerophosphate(2), Phosphorylcholine, Glycerol-phosphocholine, Sn-glycerol-3-phosphoethanolamine(P < 0.05); aureomycin significantly increased the relative abundance of phenylacetaldehyde. The KEGG results showed that quercetin and aureomycin alleviated E. coli K88-induced liver injury in broilers by significantly regulating glycerophospholipid metabolic and phenylalanine metabolism, respectively (P < 0.05). In conclusion, dietary quercetin alleviated E. coli K88-induced liver injury by regulating flora and glycerophospholipid metabolism in liver of broilers. - Source: PubMed
Publication date: 2025/09/11
Zhou ShuaishuaiFu YuxinYang QinglinLiu JunhongLi Yao - Digestive system cancers (DSCs) represent a heterogeneous group of malignancies characterized by a poor prognosis and a lack of accurate early diagnostic methods. While traditional serological biomarkers and non-coding RNA continue to be commonly diagnostic marker for these cancers, their sensitivity and specificity in detection are often limited. RNA in plasma-derived extracellular vesicles (PDEV) has emerged as a promising diagnostic tool for a variety of cancers, but its application in the detection of various DSCs has not yet been fully explored. - Source: PubMed
Publication date: 2025/09/03
Qin XiaoweiBi ZhibinLi WenbinZhang HuipengHan MingZhang KongxiWu JianHuang Lei - Lung squamous cell carcinoma (LUSC) is one of the most common subtype of lung cancer and is associated with the poor prognoses. The fibroblast growth factor receptor (FGFR) family is known to be activated through fusions with various partners across multiple cancer types, including nonsmall cell lung cancer (NSCLC). FGFR inhibitors are currently undergoing clinical evaluation for the treatment of tumors harboring these fusions. While FGFR1 amplification has been well-documented in numerous NSCLC datasets, the characterization of specific FGFR fusion variants remains limited. In this study, we identified a novel PLPP5-FGFR1 fusion in a 65-year-old male patient with lung squamous cell carcinoma through targeted RNA sequencing. The fusion junction was located between exon 1 of PLPP5 and exon 5 of FGFR1, and the result was validated by Sanger sequencing. To our knowledge, this is the first reported case of a PLPP5-FGFR1 fusion coexisting with a TP53 mutation in LUSC. These findings broaden the spectrum of potential translocation partners in FGFR1 fusions, and the clinical implications of this novel fusion on treatment outcomes and prognosis warrant further investigation and long-term follow-up. - Source: PubMed
Xiao-Ru MengXiao-Xiong ShiQian GaoYa-Jing QuLi-Li HuoYan-Yan GaoPeng-Peng XuGuan-Nan MaGui-Bing Ren - This study amied to investigate the prognostic characteristics of triple negative breast cancer (TNBC) patients by analyzing B cell marker genes based on single-cell and bulk RNA sequencing. - Source: PubMed
Publication date: 2023/12/04
Zhao FangruiZhao ChenXu TangpengLan YanfangLin HuiqingWu XiaofeiLi Xiangpan - Copy number alterations are common genetic lesions in cancer. In squamous non-small cell lung carcinomas, the most common copy-number-altered loci are at chromosomes 3q26-27 and 8p11.23. The genes that may be drivers in squamous lung cancers with 8p11.23 amplifications are unclear. - Source: PubMed
Publication date: 2023/02/21
Voutsadakis Ioannis A