Ask about this productRelated genes to: MOGAT1 antibody
- Gene:
- MOGAT1 NIH gene
- Name:
- monoacylglycerol O-acyltransferase 1
- Previous symbol:
- DGAT2L1
- Synonyms:
- DGAT2L, MGAT1
- Chromosome:
- 2q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-10
- Date modifiied:
- 2016-10-05
Related products to: MOGAT1 antibody
Related articles to: MOGAT1 antibody
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder that can lead to irreversible hepatic damage when chronic inflammation and fibrosis develop. Exercise and dietary switch have been suggested as effective strategies for improving MASLD. However, their effects in severe MASLD induced by long-term obesity remain unclear. Therefore, this study investigated the combined effects of exercise and dietary switch in a mouse model of severe MASLD induced by long-term high-fat diet feeding. The combined intervention significantly reduced body weight and improved glucose tolerance compared with either intervention alone. In addition, exercise combined with a dietary switch was associated with reduced expression of lipogenesis-related proteins, including monoacylglycerol -acyltransferase 1. The intervention was also accompanied by alterations in proteins related to mitochondrial regulation, antioxidant defense, and autophagy. Histological analysis further demonstrated improvements in hepatic steatosis and MASLD activity scores. In mice with severe MASLD, the combination of exercise and dietary switch was more effective than either intervention alone in improving hepatic lipid accumulation and molecular markers associated with MASLD. In severe metabolic dysfunction-associated steatotic liver disease (MASLD) induced by long-term obesity, exercise or dietary switch alone had limited effects on hepatic steatosis. However, the combination of exercise and dietary switch significantly improved MASLD and was associated with reduced hepatic monoacylglycerol -acyltransferase 1 expression and alterations in mitochondrial-, antioxidant-, and autophagy-related proteins. These findings highlight the importance of combined lifestyle interventions in advanced MASLD. - Source: PubMed
Publication date: 2026/05/22
Won Jong-HwaBaek Kyung-WanXiang Ying-YingKim Ji-Seok - Fat deposition plays a crucial role in regulating the production performance and meat quality of broilers. Although the heterogeneity of mammalian adipocytes has been extensively studied, research on the molecular mechanisms underlying differences in lipid droplet accumulation in avian adipocytes remains limited. This study confirmed a significant positive correlation (R > 0.81, < 0.001) between the SSC signal and lipid droplet content via fluorescence staining of lipid droplets, Oil Red O staining, and triglyceride (TG) quantification. Based on this, a label-free sorting strategy using SSC signals was established to sort differentiated chicken preadipocytes, obtaining high lipid droplet (H) and low lipid droplet (L) subpopulations, which were subsequently subjected to transcriptome sequencing and differential gene expression (DEG) analysis, followed by GO and KEGG enrichment analysis. The results indicated no significant differences in the expression of adipogenesis marker genes (, , , , ) between the high lipid droplet (H) and low lipid droplet (L) groups, suggesting that both groups are at similar stages of differentiation. KEGG analysis revealed that both the H vs. NC and L vs. NC comparisons were enriched in common pathways, including the PPAR signaling pathway, ECM-receptor interaction, focal adhesion, cytokine-receptor interaction, and calcium-Apelin signaling pathway, suggesting that both groups of cells had activated the adipogenesis program. GO analysis showed that, in both H vs. NC and L vs. NC comparisons, differentially expressed genes (DEGs) were enriched in biological processes (BPs) related to cell adhesion, nucleosome assembly, chromatin remodeling, and receptor activity, as well as cellular components (CCs) such as the extracellular matrix, cytoskeleton, and nucleosome organization, indicating extensive gene reprogramming and activation of signaling transduction during differentiation. In the H vs. L comparison, enriched pathways included ABC transporters, ECM-receptor interaction, focal adhesion, gap junctions, microtubule-related processes, and neuroactive ligand-receptor interactions, involving lipid transmembrane transport, cytoskeleton stabilization, and signal transduction regulation, suggesting that high lipid droplet cells are more mature in lipid droplet transport, storage, and homeostasis maintenance. GO enrichment results further supported this conclusion, as H vs. L specifically enriched processes related to microtubule-related processes, cell cycle, and redox reactions (BPs), as well as chromosome organization, cytoskeleton, and motor activity (CC/MF), indicating that high lipid droplet cells maintain lipid droplet fusion and metabolic homeostasis via enhanced microtubule transport and antioxidant regulation. Differential gene analysis revealed that the L group upregulated genes associated with fatty acid synthesis and elongation (, , , , ), cholesterol and isoprenoid biosynthesis (, , , , , , ), and fatty acid oxidation (, , , ), reflecting a metabolic characteristic of concurrent lipid synthesis and mobilization; the H group, conversely, upregulated genes associated with lipid droplet formation and storage (, , , , ), lipid transport (, , , , ), and antioxidant defense (, , ), exhibiting a storage and homeostasis-oriented metabolic state. In the NC, L, and H groups, the expression of five genes-, , , , and -showed a gradual increase, suggesting that these genes were associated with preadipocyte differentiation and lipid droplet deposition. In summary, although the high and low lipid droplet subpopulations of chicken preadipocytes exhibit similar differentiation states, they form distinct metabolic orientations. The L group is characterized by active lipid synthesis, fatty acid oxidation, and membrane lipid remodeling, while the H group predominantly features lipid droplet storage, lipid transport, and antioxidant homeostasis. This study highlights the molecular mechanisms underlying the metabolic heterogeneity of avian adipocytes and provides a theoretical basis for poultry fat deposition regulation and genetic improvement. - Source: PubMed
Publication date: 2026/03/12
Wang BoyuLi YantaoWang YakeChen JiayiWang JialiLi XiaopingLi Zhenhui - Understanding the biochemical basis of chicken meat flavor is important for improving meat quality. An integrated metabolomic, lipidomic, and transcriptomic approach was applied to compare breast (BM) and leg meat (LM) of 120-day-old Tianfu broilers. Compared with BM, LM showed higher pH values, a 43.05% lower drip loss, and markedly higher intramuscular fat (IMF) content (6.217% vs. 1.954%), whereas BM contained more inosine monophosphate and exhibited greater shear force. GC-MS and lipidomics identified 147 volatile compounds and 1972 lipid species, respectively, with glycerophospholipids, particularly phosphatidylethanolamine and phosphatidylcholine, closely associated with flavor differences between muscles. Multi-omics factor analysis indicated circ_015424 as a key molecular feature correlated with lipid metabolism and flavor-related pathways. Functional assays further showed that circ_015424 enhanced lipid droplet accumulation in intramuscular adipocytes via the miR-196-1-3p/MOGAT1 axis. These results clarify lipid-related mechanisms underlying muscle-specific flavor formation in chicken. - Source: PubMed
Publication date: 2026/02/21
Hu ZhiChen JiapengXu HengyongJi XuyangZhu JiajunGuo LonggeWang XinqiLiu YipingYang ChaowuYu ChunlinZhang ZengrongQiu MohanWang Yan - One important element impacting meat quality is fat metabolism, which mainly affects meat features through intramuscular fat deposition. Chinese native yellow-feathered broilers and white-feathered broilers differ significantly in intramuscular fat concentration. This study used transcriptomic and metabolomic sequencing technologies to identify a total of 173 differentially expressed genes and 259 differential metabolites in the pectoral muscles of Chahua Chicken No. 2 and Cobb broiler in order to explore the genetic mechanisms by which lipid metabolism influences meat quality in Chinese indigenous yellow-feathered and white-feathered broilers. These included differentially expressed genes like FABP1, LPL, ELOVL7, SLC27A1, MOGAT1, and ULK2, which were enriched in pathways relevant to lipid metabolism and showed strong associations with Ī³-linolenic acid and palmitaldehyde, two distinct metabolites. In order to develop local chicken germplasm resources and breed superior indigenous chicken varieties, these candidate genes could serve as the genetic foundation for the variations in meat quality and lipid metabolism between Chinese native yellow-feathered and white-feathered broilers. - Source: PubMed
Publication date: 2025/12/25
Li MengyuanLiu MengqianYang YuRuan JinruiGu ZifuGe ChangrongCao Weina - Decades of intensive breeding for rapid growth rate has resulted in increased abdominal fat content in commercial broilers, which also led to significant economic loss in this industry. In the present study, we integrated RNA-Seq datasets of 44 samples, including 22 fat- and 22 lean-line, to identify the selection signatures linked to abdominal fat content in chickens. - Source: PubMed
Publication date: 2025/11/27
Abbasabadi HosseinBakhtiarizadeh Mohammad RezaMansourizadeh HosseinGutiƩrrez-Gil Beatriz