Ask about this productRelated genes to: TMEM82 antibody
- Gene:
- TMEM82 NIH gene
- Name:
- transmembrane protein 82
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p36.21
- Locus Type:
- gene with protein product
- Date approved:
- 2007-08-02
- Date modifiied:
- 2015-10-23
Related products to: TMEM82 antibody
Related articles to: TMEM82 antibody
- Electronic cigarette (e-cig) use among U.S. adults has shifted notably, with increased adoption among younger adults and middle-aged individuals transitioning from traditional cigarettes. We herein investigated the impact of gestational e-cig aerosol exposure on uterine artery (UA) transcriptome. Timed-pregnant Sprague-Dawley rats were randomly assigned to either the pair-fed Control or the E-cig group before initiation of vaping (4 s e-cig vapor every 2 min, two episodes of 1.5 h each; gestational day (GD) 5 until GD 20). Maternal weight and placental efficiency were not altered, whereas there was a significant deficit in fetal body weight and crown-rump length in the E-cig group on GD 21. Twenty three genes were significantly upregulated, while 40 genes were downregulated in the uterine artery of the E-cig group when compared with the Control group uterine artery. The top significantly downregulated genes in the uterine artery include genes involved in extracellular matrix and Wnt signaling regulation (Smoc2, Gpc3, Frzb, Sfrp2), immune and inflammatory response (C1qtTNF3, Tmem82, Clec21), muscle contraction (Actc1) and cell migration ( Gas2l3, Ret, Robo2). Top upregulated genes in the uterine artery (Vsig4, Agt, Cntn2, Kcnk5, Fhad1, Fgf13, Ctxn1, Prg4, and Pln) included genes involved in immune response and regulation (Vsig4, Kcnk5), and uterine artery vasodilation (Agt). Significant differences between the Control and E-cig groups were validated using Principal Component Analysis (PCA) and k-means clustering. These findings reveal how e-cig aerosol exposure during pregnancy may disrupt key biological processes in the uterine artery that delivers O and nutrients to the fetoplacental compartment. - Source: PubMed
Publication date: 2025/12/04
Carabulea Alexander LNaik Vishal DJaneski Joseph DJiang HongVenkatachalam SaravananRamadoss Jayanth - Colorectal cancer (CRC) represents one of the most frequent human malignancies with its underlying pathogenesis still unclear. The prevalence of multi-omics in screening biomarkers associated with CRC has largely accelerated our understanding into the pathophysiology of CRC. The present work aimed to mine the Gene Expression Omnibus (GEO) datasets associated with CRC studies and identify potential targets correlated with CRC pathogenesis. - Source: PubMed
Publication date: 2022/04/07
Guo ShuaiSun Yang - There is an urgent need to identify biomarkers for hepatocellular carcinoma due to limited treatment options and the poor prognosis of this common lethal disease. Whole-transcriptome shotgun sequencing (RNA-Seq) provides new possibilities for biomarker identification. We sequenced ∼250 million pair-end reads from a pair of adjacent normal and tumor liver samples. With the aid of bioinformatics tools, we determined the transcriptome landscape and sought novel biomarkers by further empirical validations in 55 pairs of adjacent normal and tumor liver samples with various viral statuses such as HBV(+), HCV(+) and HBV(-)HCV(-). We identified a novel gene with coding regions, termed DUNQU1, which has a tissue-specific expression pattern in tumor liver samples of HCV(+) and HBV(-)HCV(-) hepatocellular carcinomas. Overexpression of DUNQU1 in Huh7 cell lines enhances the ability to form colonies in soft agar. Also, we identified three novel differentially-expressed protein-coding genes (ALG1L, SERPINA11 and TMEM82) that lack documented expression profiles in liver cancer and showed that the level of SREPINA11 is correlated with pathology stages. Moreover, we showed that the alternative splicing event of FGFR2 is associated with virus infection, tumor size, cirrhosis and tumor recurrence. The findings indicate that these new markers of hepatocellular carcinoma may be of value in improving prognosis and could have potential as new targets for developing new treatment options. - Source: PubMed
Publication date: 2013/10/21
Lin K-TShann Y-JChau G-YHsu C-NHuang C-Y F