Ask about this productRelated genes to: RNF171 antibody
- Gene:
- MARCH1 NIH gene
- Name:
- membrane associated ring-CH-type finger 1
- Previous symbol:
- -
- Synonyms:
- FLJ20668, MARCH-I, RNF171
- Chromosome:
- 4q32.2-q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-26
- Date modifiied:
- 2018-02-13
Related products to: RNF171 antibody
Related articles to: RNF171 antibody
- Inadequate postoperative pain management predisposes patients to delayed recovery, impairs mother-infant interaction, prolongs hospital stay, and increases the risk of chronic pain development. In resource-limited settings, postoperative pain management remains challenging because of inadequate administration of analgesics and a high patient-to-nurse ratio, which limits adequate pain assessment and timely management. - Source: PubMed
Publication date: 2026/05/30
Jiru Dejene MoredaDoba Yonas SagniName Hunde Amsalu - Herpes simplex virus 1 (HSV-1) infection contributes to immunopathogenic diseases and lacks an effective vaccine. Improving antigen presentation is key to better vaccine strategies and more robust immune responses. Here, we show that optineurin (OPTN), an autophagy receptor traditionally involved in protein recycling, unexpectedly stabilizes RICTOR (mechanistic target of rapamycin complex 2 [mTORC2]), a crucial step in enhancing MHC class II surface expression in dendritic cells. OPTN regulates the AKT/mTOR/signal transducer and activator of transcription 3 (STAT3) pathway, with the AKT2 isoform playing a central role. Using single-cell RNA sequencing (scRNA-seq) and transgenic mouse models, we identify the mechanistic details of this pathway. Dysregulation impairs antigen presentation, weakening immunity and vaccine efficacy. Our findings uncover a previously unknown function of OPTN and highlight its role in coordinating innate and adaptive immune defenses, with implications for vaccine development and immune response modulation in HSV-1 and other viral and bacterial diseases. - Source: PubMed
Publication date: 2026/04/16
Kadam RashmiPatil ChandrashekharFeferman LeonidMaienschein-Cline MarkChlipala GeorgeBorole PiyushBhattacharya IlinaOrameh ChimaNyugen TaraTseng HenryShukla Deepak - Membrane-associated RING-CH1 (MARCH1) is a critical membrane-bound RING domain E3 ubiquitin ligase that primarily regulates immune cell development, immune responses, antigen presentation modulation, and metabolic functions. Its role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) remains elusive. This study aimed to investigate the function of MARCH1 in HFpEF. - Source: PubMed
Zhu YunlongFan JieTang LiangZhou YuyingJiang KangTan DanHuang HaoboWu MingxingZeng JianpingYang HuiZhou Shenghua - Cisplatin (DDP) resistance constitutes a major obstacle associated with poor prognosis in patients with lung adenocarcinoma (LUAD). Membrane-associated RING-CH finger protein 1 (MARCH1) contributed to shaping an inflamed tumor microenvironment, which is linked to chemotherapy resistance in LUAD patients. However, its role and underlying mechanisms in DDP-resistant LUAD patients remains to be elucidated. Herein, we observed that MARCH1 was downregulated in DDP-resistant lung cancer tissues, and low MARCH1 expression was correlated with poor prognosis of LUAD patients. MARCH1 overexpression enhanced DDP sensitivity, suppressed proliferation and invasion, and promoted apoptosis in DDP/A549 cells. Co-culture experiments revealed that MARCH1 overexpression suppressed the polarization of tumor-associated macrophages toward the M2 phenotype, as validated by ELISA, flow cytometry, Western blotting, and immunofluorescence staining. MARCH1 contributed to shape the tumor immune microenvironment, affecting immunostimulators, MHC molecules, chemokines, and receptors. Moreover, co-immunoprecipitation and ubiquitination experiments confirmed that MARCH1 facilitated the ubiquitination and degradation of solute carrier family 25 member 17 (SLC25A17). Rescue experiments demonstrated that overexpression of SLC25A17 attenuated the enhancement of DDP sensitivity evoked by MARCH1 reintroduction through promoting M2 macrophage polarization. Additionally, the tumor-suppressive effect of MARCH1 in LUAD was confirmed in vivo. In conclusion, our findings indicated that MARCH1 suppressed lung cancer progression by blocking macrophage M2 polarization and DDP resistance through ubiquitinating SLC25A17, thus providing a new mechanism for cisplatin resistance in LUAD. - Source: PubMed
Wang HuifengSun YanyanZi RuiShi TingtingDong Hui - Kidney transplant rejection (KTR) poses significant challenges to long-term graft survival, with involvement from ubiquitination-related genes (URGs) in immune modulation. This study aimed to identify key URGs linked to KTR and develop a predictive model for rejection risk. mRNA array data from the Gene Expression Omnibus were analyzed to find differentially expressed genes in GSE98320, which were intersected with URGs to yield 16 DE-URGs. Gene Ontology and KEGG enrichment analysis highlighted the NF-kappa B and TNF signaling pathways. A URGScore model stratified patients and revealed significant differences in immune cell infiltration, especially among Treg cells, demonstrating strong predictive performance in the discovery cohort (AUC = 0.774, 95% CI 0.747–0.800). Six signature genes (,,,,,) were identified, and their expression displayed a subtype-dependent gradient, increasing from antibody-mediated rejection to T cell-mediated rejection and reaching the highest levels in mixed rejection. These genes were incorporated into a nomogram, which achieved an AUC of 0.771 (95% CI 0.745–0.798). Validation in independent datasets confirmed the model’s reliability. In the two transplant rejection cases, and showed higher expression than the other biopsy samples, while generalized high expression of all marker genes was observed in an IgA nephropathy patient. Together, these findings demonstrate the clinical relevance of URG-based biomarkers in KTR and provide molecular insight into immune-mediated rejection. - Source: PubMed
Publication date: 2026/02/10
Shan ZhengfeiYu ShengqiangWang JiantaoCui JianxinWei HaijianFu XiaohuaZhang ChenZhang Chengjun