Ask about this productRelated genes to: BACE2 antibody
- Gene:
- BACE2 NIH gene
- Name:
- beta-secretase 2
- Previous symbol:
- AEPLC
- Synonyms:
- CEAP1, DRAP, ALP56
- Chromosome:
- 21q22.2-q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2018-05-09
Related products to: BACE2 antibody
Related articles to: BACE2 antibody
- - Source: PubMed
Publication date: 2026/03/28
Garvert LindaKiller SarahKirchner KevinVölzke HenryVölker UweGrabe Hans JörgenVan der Auwera Sandra - Essential tremor, a movement disorder characterized by an upper-limb postural and action tremor, is among the most common neurological disorders, affecting 1% of the population worldwide. Despite strong evidence for genetic factors driving the etiology of essential tremor, the underlying pathophysiology remains poorly understood. To understand the effects of genetic risk factors in essential tremor on the cerebellum, the brain region suspected to be affected by the disease, we built a population-scale single-cell atlas of the human cerebellar cortex comprising more than 1 million cells from 109 individuals. Here, using single-cell expression quantitative trait loci and Mendelian randomization, we show that essential-tremor-associated variants in the BACE2 locus are causally linked to its downregulation in cerebellar oligodendrocytes. We highlight a genetically vulnerable population of BACE2-expressing immature oligodendrocytes, suggestive of demyelination. We also identify dysfunctional processes affecting interactions between neuronal populations and oligodendrocytes in essential tremor. Our findings suggest a crucial role for cerebellar oligodendrocytes in the pathogenesis of essential tremor. - Source: PubMed
Publication date: 2026/03/19
Castonguay Charles-EtienneAboasali FarahMedeiros MirandaAlipour PariaBornais KateBecret ThéodoreSchmilovich ZoeKhayachi AnouarRajput AlexDion Patrick ARouleau Guy A - Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, with a poor prognosis due to radiotherapy and chemotherapy resistance. Novel systemic treatments have limitations, highlighting the need for identifying new oncogenic genes and therapeutic targets. Beta-secretase 2 () is involved in the progression of multiple cancers, but its role and mechanism in LUAD remain unreported. This study aimed to explore the expression pattern, biological function, and underlying mechanism of in LUAD. - Source: PubMed
Publication date: 2026/02/25
You ZhixinHe WeiZhou YanfeiLi Huijiao - Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β plaques, derived from the amyloid precursor protein through sequential cleavage by β-secretase 1 (BACE-1) and γ-secretase. BACE-1 is therefore a key drug target for designing of selective inhibitors to avoid off-target effects associated with BACE-2 inhibition. The objective of this study was to design novel BACE-1 inhibitors using a structure-based drug design approach. A focused compound library was designed based on the SAR of N-(4-fluorophenyl)formamide derivatives. ADME predictions were performed to assess pharmacokinetic suitability. Compounds showing favorable ADME profiles were subjected to molecular docking against the BACE-1 enzyme. The top-scoring hit, compound (-5.48 (kcal/mol), was further evaluated using a 200 ns MD simulation to assess the stability of its binding interactions with BACE-1. Designed compounds indicated acceptable physicochemical and ADME characteristics. Molecular docking identified compound as exhibiting favorable binding interactions with binding pocket residues of BACE-1. The 200 ns MD simulation further confirmed the stability of the docked complex. MD simulations confirmed that 9.7 forms stable interactions with the catalytic residue ASP32 and key hydrophobic residues TRP115 and PHE108 of BACE-1. These important interactions are absent in the reference compound verubecestat. The multi-step computational analysis suggests that compound is a promising and selective BACE-1 inhibitor. Its favorable ADME profile, favorable docking interactions, and stable MD simulation behavior highlight its potential as a hit compound for further optimization in the development of anti-Alzheimer's agents. - Source: PubMed
Publication date: 2025/12/19
Gandhi VaibhavDewaker VarunAgarwal UmaPatil Vaishali MPark Sung TaekKim Hyeong SuVerma Saroj - Alzheimer's disease (AD) and neuroblastoma are distinct conditions that affect the nervous system. However, they share some molecular similarities, particularly concerning the amyloid precursor protein (APP) and related pathways. While previous studies have demonstrated a correlation between neurodegenerative diseases and various tumors, the causality and direction of their relationship remain unclear. Oleacein, one of the most abundant polyphenols in Extra Vergin Olive Oil (EVOO) may exert neuroprotective and/or antitumor effects. In this study, we explored the effects of the polyphenol oleacein, obtained by a simple and efficient sustainable semi-synthesis starting from natural oleuropein, on AD-related genes in SHSY5Y, a human neuroblastoma cell line, and in 3Tg-iAstro cells, immortalized astrocytes from the hippocampus of 3xTg-AD mice, to identify potential shared biological pathways. - Source: PubMed
Publication date: 2026/01/09
Polerà NicolettaJuli GiadaAgapito GiuseppeProcopio AntonioLucibello MariaNardi MonicaBonacci SoniaMilano MariannaCannataro MarioLim DmitryAltomare EmanuelaArbitrio Mariamena