Ask about this productRelated genes to: SSR1 antibody
- Gene:
- SSR1 NIH gene
- Name:
- signal sequence receptor subunit 1
- Previous symbol:
- -
- Synonyms:
- TRAPA
- Chromosome:
- 6p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-16
- Date modifiied:
- 2016-05-05
Related products to: SSR1 antibody
Related articles to: SSR1 antibody
- Keloids are pathological scars with incompletely understood pathogenesis. This study aims to identify the key genes and regulatory networks potentially involved in keloid formation by integrating single-cell transcriptomics (scRNA-seq), protein quantitative trait loci (pQTL), Mendelian randomization (MR) analyses, colocalization, and comprehensive functional characterization. - Source: PubMed
Wu Hui-HuiMeng Yong-XiaLiu Juan-HuaLuo Di-QingChen Mu-KaiZhao Yu-Kun - Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with a poor prognosis, and its molecular mechanisms remain unclear. Our previous research identified the signal sequence receptor subunit delta (SSR4) of the TRAP complex as a potential ESCC biomarker. The TRAP complex, composed of SSR1, SSR2, SSR3, and SSR4, is essential for protein translocation, folding, and quality control, crucial for cellular balance. While individual TRAP subunits have been studied, a comprehensive understanding of their roles in human diseases is lacking. - Source: PubMed
Publication date: 2026/02/06
Zhang JiaqiWan XingGong Aixia - During the Vietnam War, US military personnel were widely exposed to a tactical defoliant called Agent Orange, contaminated with a toxic endocrine-disrupting chemical, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Vietnam-era US Veterans exposed to Agent Orange display increased risk of thyroid cancer, yet the molecular mechanisms behind this risk remain largely unexplored. As aberrant DNA methylation is a hallmark of cancer development, we conducted a retrospective case-case study of Vietnam-era US Veterans to investigate differential DNA methylation profiles of Agent Orange exposed thyroid cancers compared to unexposed thyroid cancers. This exploratory study included 44 Veterans with differentiated thyroid cancer, treated at two Veterans Affairs (VA) medical centers (1990-2020): 23 Agent Orange exposed cases, identified through VA benefits/medical record review, and 21 unexposed cases. We profiled genome-wide tumor DNA methylation with the Infinium Methylation EPICv2 array. We used linear regression models to compare methylation in the exposed compared to unexposed group. Models were adjusted for age, VA location, and cell type proportions. Differentially methylated CpGs were used for gene set enrichment analyses. Agent Orange exposure was associated with differential methylation at 309 CpGs (nominal p-value <0.001) in thyroid tumors from exposed compared to those from the unexposed group. However, we did not detect significant CpGs after adjusting for multiple comparisons. Some of the top associations included CpGs located to cancer-related genes (i.e. CELF2, OTX2, SSR1, and EBF1). Gene set enrichment analysis revealed enrichment of hedgehog signaling and anti-folate resistance pathways. In this exploratory analysis, we identified differentially methylated loci linked to thyroid cancer in Agent Orange exposed Veterans. Further research is necessary to replicate our findings in a larger cohort including Agent Orange exposure determination through biomarker assessment, and to elucidate mechanisms behind these associations in in vitro exposure models. - Source: PubMed
Publication date: 2025/12/11
Amreen BushraLesseur CorinaSadikki HachemSaul Shira RKazi SofiaLeung Angela MNguyen Elise YMonaghan MathildaTaioli EmanuelaGenden Eric MChen Jiavan Gerwen Maaike - Proper testicular development is essential for spermatogenesis, a complex biological process that depends on the continuous proliferation and differentiation of spermatogonial stem cells (SSCs). These processes are tightly regulated by the SSC niche. Understanding the developmental mechanisms of SSCs is therefore critical for elucidating the basis of male fertility. Recent studies have shown that members of the G-protein-coupled receptor (GPCR) superfamily play key roles in ion and water balance in the epididymis, development of efferent ductules, blood-epididymal barrier formation, and sperm maturation. To investigate SSC development in humans, we performed microarray analysis to examine G-protein gene expression in single cells from six human testes. Our analysis revealed that genes such as LEPROT, LRRC15, LPAR1, SSR1, BMPR2, TNFRSF11B, TNFRSF10D, DDR2, SSR3, SIGMAR1, GRIA3, OGFRL1, GRIK2, TMEM87A, GPR108, TNFRSF1A, S1PR2, and VASN were down-regulated, while FLT1, ADGRG6, CSF1R, IL7R, ADGRL3, OR4N4, MMD, SIRPB1, OR5I1, PTGDR, MPL, and GPR107 were up-regulated. Single-cell transcriptomic and bioinformatic analyses were used to validate SSC-specific gene expression and assist in SSC isolation and sorting. Additionally, immunofluorescence labeling at different developmental stages provided insights into the spatial and temporal dynamics of spermatogonia. Our findings offer new insights into the molecular mechanisms governing human SSC development and provide a valuable foundation for advancing SSC-based fertility research and therapeutic applications. - Source: PubMed
Publication date: 2025/07/22
Hashemi Karoii DanialBavandi SobhanAbroudi Ali ShakeriDjamali MelikaAzizi HosseinSkutella Thomas - This study investigated the genetic diversity of subsp. ()-the causative agent of paratuberculosis-isolated from different host species in Germany. A total of 500 isolates from 243 cattle herds and 9 other host species originating from 13 federal states were genotyped. A multi-target approach was applied, comprising IS-RFLP with EII and I digestion; MIRU-VNTR; and SSR1, SSR8, and SSR9 analysis. In total, 93 combined genotypes were identified, 84 in cattle and 21 in non-cattle isolates. Ninety genotypes were assigned to the C-type group, and three genotypes (three from sheep and one from cattle) were assigned to the S-type/subtype III group. Cluster analysis divided genotypes into subgroups similar to those shown for WGS-SNP-based phylogenetic trees. New genotypes were revealed, including INMV262-267 and a specific sequence at locus VNTR7. Five genotypes that were predominant in cattle were also detected in sheep, goats, and deer. The majority of genotypes [61%] were identified only once. Polyclonal infections were observed in individual animals and herds, and various potential transmission linkages were uncovered. This high genotype richness of reflects the long history of paratuberculosis in Germany and intensive nationwide animal movement and international trading activity. - Source: PubMed
Publication date: 2025/05/30
Möbius PetraPrice-Carter MarianKöhler Heike