Ask about this productRelated genes to: FAM19A4 antibody
- Gene:
- TAFA4 NIH gene
- Name:
- TAFA chemokine like family member 4
- Previous symbol:
- FAM19A4
- Synonyms:
- TAFA-4
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
Related products to: FAM19A4 antibody
Related articles to: FAM19A4 antibody
- Host resistance to infection relies on coordinated interactions between the immune and nervous systems. However, the molecular mechanisms underlying this cross-regulation remain unclear, particularly during viral infections. We have shown that herpes simplex virus type 1 directly activates sensory neurons, inducing production of the neuropeptide substance P (SP) and the neurokine TAFA4. These mediators played independent, tissue-specific immunoregulatory functions in the skin and dorsal root ganglia (DRGs), the main sites of viral replication. In the skin, the SP produced by transient receptor potential vanilloid type 1 (TRPV1) sensory neurons limited neutrophil infiltration through the Mas-related G protein-coupled receptor member A1 (MRGPRA1) receptor and promoted skin healing, revealing an unexpected anti-inflammatory role for this neuropeptide. In infected DRGs, a TAFA4-interleukin (IL)-10 pathway promoted the resolution of inflammation after viral clearance. Together, these neuroimmune regulatory pathways reduced the detrimental impact of the infection on host fitness without directly altering pathogen elimination, revealing how the sensory nervous system has developed several mechanisms to promote disease tolerance. - Source: PubMed
Publication date: 2026/02/25
Roger AnaisFohrer TiphaineMardelle UgoThomas IsaacNezhad Sara TeimouriGupta SurbhiDory AlissaJeyanathan VidthiyaLiaghat AndishehMielle JulieKhlifi Hakim MedjouelSantamaria Jeremy CBrunet ElenaGouilly JordiEscaliere BertrandBretaud NinonCrosson ThéoBarbon Pierre-VincentMossadegh-Keller NoushinIrla MagaliBasta SamBroggi AchilleMilpied PierreGour NainaFeuillet VincentHoeffel GuillaumeDong XinzhongKaufmann EvaReynders AnaTalbot SébastienMoqrich AzizUgolini Sophie - Intervertebral disc degeneration (IVDD) is a complex pathological process involving inflammation, oxidative stress, and immune dysregulation. Emerging evidence suggests that neuroimmune interactions contribute to IVDD progression, but the role of neuropeptide-like factors remains poorly understood. - Source: PubMed
Publication date: 2026/01/31
Han JiahengHuang JieDing ZhiliJiang QiangYang GuangnanLu ZhengcaoMa JingboZhang YanDing Yu - Triage of human papillomavirus (HPV)-positive women with atypical squamous cells of undetermined significance (ASC-US) remains a longstanding clinical challenge in cervical cancer screening, as conventional strategies often lead to excessive colposcopy referrals. We conducted a diagnostic cohort study of 195 HPV-positive women who underwent ASC-US cytology. - Source: PubMed
Publication date: 2026/02/02
Xia WeiweiWang JingYang XiaoxiaoSha YingHou FangLi JieTeng ZhenghuaWang JuanShen FangrongJie Peng - To improve human papilloma virus (HPV) screening, more effective triage methods for HPV-positive samples need development and validation. Cytology, the most common triage method today, is subjective and can only be applied to professionally collected samples. Methylation status has been shown to be informative, as genes are highly methylated in HPV-induced cervical dysplasia and cancer. This study aimed to assess whether triaging HPV-positive samples using molecular methods, such as methylation and genotyping for high-risk HPV types, could be as effective as cytology in cervical screening. - Source: PubMed
Publication date: 2025/10/13
Larsson Gabriella LillsundeCarlsson JessicaHelenius GiselaBergengren Lovisa - Cervical intraepithelial neoplasia grade 2 (CIN2) can spontaneously regress in a sizable proportion of cases. The aim of this prospective multicenter cohort study was to identify the biomarkers associated with a high probability of regression. A total of 319 women aged 25-45 years fulfilling predefined inclusion and exclusion criteria (full visibility of transformation zone and lesion; no previous history of CIN2+ or immune impairment) were enrolled and subjected to active surveillance for 24 months. HPV genotyping, p16/ki67 expression, methylation status of FAM19A4/miR124-2 genes, and cytology were evaluated at baseline. The probability of CIN2 regression according to the different biomarkers was evaluated through binomial logistic regression. At follow-up, regression, persistence, and progression (evaluated on 294 women) were recorded in 165 (56%), 68 (23%), and 61 (21%) cases, respectively; no association with age was observed. Overall, 110 women underwent excisional treatment during follow-up; 53 CIN2 and 50 CIN3+ were diagnosed. The probability of CIN2 regression significantly increased with early HPV negativity (odds ratio [OR] 6.45, 95% confidence intervals [CI] 1.68-42.6), no p16/ki67 expression (OR 2.49, 95%CI 1.38-4.52), and unmethylated status (OR 2.12, 95%CI 1.09-4.20). Our results indicate that active CIN2 surveillance could be implemented for women up to 45 years, after selection according to anatomo-clinical criteria and biomarker status. To improve feasibility, the biomarkers can be used sequentially, taking advantage of the HPV genotyping available in primary screening tests, and eventually refining the selection by using the other biomarkers in selected subgroups. - Source: PubMed
Publication date: 2025/08/30
Frayle HelenaGori SilviaPagan AlessioSoldà MarikaRomagnolo CesareInsacco EgleLaurino LiciaMatteucci MarioSordi GiuseppeBusato EnricoZorzi ManuelMaggino TizianoDel Mistro Annarosa