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- Lung adenocarcinoma (LUAD) exhibits high genetic heterogeneity and an immunosuppressive tumor microenvironment (TME), often characterized by reduced immune cell infiltration. Tumor-intrinsic regulators of cell cycle and genomic stability, such as MAD2L1, may also influence immune evasion, but their mechanistic role in LUAD remains unclear. - Source: PubMed
Publication date: 2026/01/14
Saini ChainseeVats PrernaBaweja BhavikaNema Rajeev - Despite significant evidence of a genetic contribution to strabismus, precise genetic mechanisms have not been identified. There are distinct population differences in the prevalence of strabismus and its subtypes. This study aimed to explore the genetic contributions to strabismus in different ancestral groups. - Source: PubMed
Publication date: 2025/07/01
Lee Kyoung A ViolaTesdahl CoreyAboobakar Inas FJain AshishMartinez Sanchez MayraJin KimberlyOke IsdinWhitman Mary C - Lung adenocarcinoma, which is the second most prevalent cancer in the world, has a poor prognosis and a low 5-year survival rate. The MS4A protein family is crucial to disease development and progression, particularly for cancers, allergies, metabolic disorders, autoimmune diseases, infections, and neurodegenerative disorders. However, its involvement in lung adenocarcinoma remains unclear. In this study, we found that 11 MS4A family genes were upregulated or downregulated in lung adenocarcinoma. Furthermore, we described the genetic variation landscape of the MS4A family in lung adenocarcinoma. Notably, through functional enrichment analysis, we discovered that the MS4A family is involved in the immune response regulatory signaling pathway and the immune response regulatory cell surface receptor signaling pathway. According to the Kaplan-Meier curve, patients with lung adenocarcinoma having poor expression of MS4A2, MS4A7, MS4A14, and MS4A15 had a low overall survival rate. These four prognostic genes are substantially associated with immune-infiltrating cells, and a prognosis model incorporating them may more accurately predict the overall survival rate of patients with lung adenocarcinoma than current models. The findings of this study may offer creative suggestions and recommendations for the identification and management of lung adenocarcinoma. - Source: PubMed
Publication date: 2023/07/18
Zheng ZijunLi HuipingYang RunjiaoGuo Hui - Behçet's syndrome (BS) is a variable vessel vasculitis characterised by heterogeneity of organ manifestations. Antigen-presenting cells, such as macrophages and T cells, play critical roles in their immunopathology. This study aimed to identify hub genes and biological processes in patients with BS. - Source: PubMed
Publication date: 2022/10/12
Zou Jun - The action of immune checkpoint inhibition (ICI) largely depends on antibody-dependent cellular phagocytosis (ADCP). We thus aim to develop ADCP-based ccRCC risk stratification as both prognostic and therapeutic markers of ICI. - Source: PubMed
Publication date: 2022/05/16
Li KunpingLi YuqingLyu YinfengTan LinyiZheng XinyiJiang HaowenWen HuiFeng Chenchen