Ask about this productRelated genes to: RNF153 antibody
- Gene:
- MARCH5 NIH gene
- Name:
- membrane associated ring-CH-type finger 5
- Previous symbol:
- RNF153
- Synonyms:
- FLJ20445, MARCH-V, MITOL
- Chromosome:
- 10q23.32-q23.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2018-02-13
Related products to: RNF153 antibody
Related articles to: RNF153 antibody
- Diabetic cardiomyopathy (DCM) is a diabetes mellitus-induced pathophysiological condition caused by unfavorable myocardial sequelae, with more severe cardiac dysfunction observed in patients with diabetes than in those without diabetes. Recently, ferroptosis has been implicated in DCM; however, its role in DCM remains incompletely elucidated. This study was conducted to examine the impact of mitochondrial ubiquitin ligase (MITOL/March5) and the mitophagy receptor Parkin on DCM-induced cardiac dysfunction, as well as the effect of ferritinophagy. Wild-type and db/db mice were fed normal chow or a high-fat diet and subjected to streptozotocin treatment. Cardiac geometry and function, as well as ferroptosis-related biomarkers, were assessed upon completion of experiments. Our findings revealed that DCM induced notable alterations in cardiac geometry by increasing myocardial fibrosis and ferroptosis, involving increased reactive oxygen species production and lipid accumulation. Nuclear receptor coactivator 4 (NCOA4)-related ferroptosis was significantly activated, whereas Parkin-dependent mitophagy was dramatically inhibited. However, adeno-associated virus (AAV)-MITOL treatment markedly attenuated cardiac dysfunction and ferroptosis with those in the DCM group. Furthermore, Ad Parkin alleviated NCOA4-mediated ferroptosis and suppressed myocardial apoptosis compared with those in the high-glucose/high-fat group. Our in vitro analysis demonstrated that MITOL inhibition compromised cardiomyocyte function and elicited mitochondrial injury and lipid peroxidation, the effects of which were negated by Parkin activation. This study underscores the pivotal protective role of the MITOL/Parkin signaling pathway against DCM-induced cardiac dysfunction in NCOA4-mediated ferritinophagy. - Source: PubMed
Publication date: 2026/04/11
Lu LinheLiu YangShao YalanXiong XiangZhai MengenYang JianYang Lifang - Sepsis is a life-threatening condition with high morbidity and mortality, where acute lung injury (ALI) is one of the earliest and most severe complications. Macrophage-mediated overactivation of inflammation and subsequent release of pro-inflammatory cytokines cause significant damage to pulmonary epithelial cells, playing a critical role in the progression of sepsis-induced ALI. This study successfully investigated the role of HUVEC-derived exosomes in the treatment of ALI and designed a novel engineered vesicle for therapeutic application. - Source: PubMed
Publication date: 2026/01/22
Lai WeiAhan SonghelaYing ZhangJiang Wanli - Epithelial ovarian cancer is one of the most lethal gynecological malignancies worldwide. Its development strongly depends on several genetic and environmental factors, with metabolic components and cellular redox homeostasis alterations playing a significant a role in its development and disease progression. In this review, we summarize the contribution of mitochondrial and endoplasmic reticulum (ER) stress in the pathogenesis of epithelial ovarian cancer along with their role as potential biomarkers and therapeutic targets, including proteins of glucose metabolism, mitochondrial fission and fusion, mitophagy, membrane-associated ring-CH-type finger 5 (MARCH5), A-kinase anchoring proteins (AKAPs), proteins regulating mitochondrial Ca homeostasis, mitochondrial unfolded protein response (UPRmt) proteins, activating transcription factors (ATFs), CCAAT enhancer binding protein (C/EBP) homologous protein (CHOP), 'mitokines', GRP75, and GRP78. Although many of these potential targets are in preclinical phase, they have a high potential to become valuable alternative or additive treatments for epithelial ovarian cancers. - Source: PubMed
Publication date: 2025/12/28
Wappler-Guzzetta Edina AmaliaMargittai EvaVeszelyi KrisztinaPickard ShanelMerwin CarolineMolvarec AttilaCzegle Ibolya - Alcoholic liver disease (ALD) is among the most prevalent health issues caused by chronic alcohol consumption. The mitochondrial E3 ligase Membrane Associated Ring-CH-type Finger 5 (MARCH5, also known as MITOL) is involved in mitochondrial fission in ALD. Gigantol (Gig) has been reported to alleviate oxidative dysfunction and inflammation in liver injury, but its effects on ALD and the mechanisms underlying these effects are not completely comprehended. This study aimed to explore the potential effects and mechanisms of Gig against ALD. - Source: PubMed
Publication date: 2025/11/22
Wu YangshengDai ShijieLi ZhemingXu LanmanZhang YuJiaQiu JiannanChen LinLin YiyouMao MingjiangXu JiangleiLi ShouyeYuan XiaofengDou Xiaobing - - Source: PubMed
Publication date: 2025/11/11
Valentino IleniaCantafio Maria Eugenia GalloTorcasio RobertaMurfone PierpaoloGanino LudovicaGallo AlessiaCuscino NicolaPerrotta IdaTallarigo FedericoMesuraca MariaGentile MassimoViglietto GiuseppeAmodio Nicola