Ask about this productRelated genes to: CPT1B antibody
- Gene:
- CPT1B NIH gene
- Name:
- carnitine palmitoyltransferase 1B
- Previous symbol:
- -
- Synonyms:
- M-CPT1, CPT1-M
- Chromosome:
- 22q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-14
- Date modifiied:
- 2015-12-04
Related products to: CPT1B antibody
Related articles to: CPT1B antibody
- This study elucidates the mechanism by which enhances meat quality in finishing lambs via modulation of the jejunal microbiota and muscle metabolism. In a 60-day trial, 32 lambs were fed diets supplemented with 0%, 1%, 3%, or 5% . supplementation significantly improved meat color, elevated amino acid (AA) and polyunsaturated fatty acid (PUFA) levels, and reduced saturated fatty acid content in the muscle. 16S rRNA gene sequencing identified an enrichment of specific jejunal microbes, including and . Integrated microbiota-metabolome analysis indicated that modulated the D-amino acid metabolism pathway. Transcriptome analysis revealed the upregulation of key genes involved in fatty acid β-oxidation (carnitine palmitoyltransferase 1B, ) and amino acid synthesis (glutamic-oxaloacetic transaminase 1, ). In conclusion, enhances lamb meat quality by remodeling the jejunal microbiota and concurrently promoting both fatty acid β-oxidation and AA synthesis in muscle. - Source: PubMed
Publication date: 2026/04/05
Zhao JiantaoLi ShuWang JingleiZeng WeibingQi YayinXu XiaolinFan JianhuaChen ChengZhang Wenju - This experiment investigated the effects of dietary Krasch. (AOK) supplementation on the n3-polyunsaturated fatty acid (n3-PUFA) profile of subcutaneous adipose tissue (SADT) in Arbas cashmere goats and explored the underlying transcriptional mechanisms. Forty healthy, weaned kids (120 ± 10 days of age; similar body weight) were randomly allocated to two groups ( = 20): a control group (CON, basal diet) and an AOK group (AOK, basal diet with 3% of the roughage replaced by AOK). The feeding trial spanned 104 days, consisting of a 14-day adaptation period and 90 days of data acquisition. Compared with the CON group, AOK significantly reduced the content of saturated fatty acids (SFAs) and n6-polyunsaturated fatty acids (n6-PUFAs)/n3-PUFAs (n6/n3). In contrast, the levels of n3-PUFAs in the SADT of cashmere goats increased markedly ( < 0.05). Compared with the CON group, AOK exhibited significantly higher activities of hormone-sensitive lipase (HSL) ( = 0.027), adenylyl cyclase 2 (ADCY2) ( = 0.010), adenylyl cyclase 5 (ADCY5) ( = 0.046), cluster of differentiation 36 (CD36) ( = 0.013), solute carrier family 27 member 4 (SLC27A4) ( = 0.021), and fatty acid binding protein 4 (FABP4) ( = 0.040), along with significantly lower activities of fatty acid synthase (FAS) ( = 0.002), lipoprotein lipase (LPL) ( = 0.048), and stearoyl-coa desaturase (SCD) ( = 0.026) in SADT. Compared with the CON group, the activities of superoxide dismutase (SOD) ( = 0.032), catalase (CAT) ( = 0.010), glutathione peroxidase (GSH-PX) ( = 0.029), and total antioxidant capacity (T-AOC) ( = 0.002) were significantly increased in the AOK group. Transcriptomic profiling revealed that AOK supplementation downregulated mRNA levels of , 5, , , , 1 (1), stearoyl- 2 (2), 1 (1), 1 (1), (), 1 (1), 1 (1), 27 2 (272), 4 (4), and 1 (1) ( < 0.05). It also markedly induced 4 (4) ( < 0.01) in SADT. Genes significantly enriched in the adenosine-monophosphate-activated protein kinase (AMPK) signaling pathway included , 1, 1, and 1 ( = 0.010). Genes significantly enriched in the phosphatidylinositol 3-kinase-akt (PI3K-Akt) signaling pathway included 1 and 4 ( = 0.015). 1, 2, and 1 were identified as the genes significantly enriched in the insulin resistance signaling pathway ( = 0.048). was the only gene significantly enriched in the cholesterol metabolism pathway ( = 0.049). Genes showing a tendency toward significant enrichment in the peroxisome-proliferator-activated receptor (PPAR) signaling pathway included 4, 1, 1, and ( = 0.051). These interconnected cascades improve insulin sensitivity, stimulate triglyceride (TG) hydrolysis, and modulate n3-PUFA levels. Supplementation with AOK enhances n3-PUFA content by accelerating TG breakdown while simultaneously restraining FA oxidation in SADT. Consequently, AOK supplementation can be effectively used to enhance the nutritional value of cashmere goat meat through improved n3-PUFA deposition in SADT. - Source: PubMed
Publication date: 2026/04/02
Jiang LianguangZhao YanliZhang QingyueZhang ShangxiongGuo XiaoyuGuo YongmeiYan Sumei - Tributyrin (TB), as a novel feed additive, holds broad market prospects and is crucial for promoting fish growth and maintaining intestinal health. We first identified the fatty acid metabolism-related gene in the intestines of mandarin fish () from the TB-supplemented group. A total of 600 mandarin fish (200.0 ± 5.0 g) were evenly allocated into three groups. The control group (C) received only the standard extruded feed, while the experimental groups were supplemented with tributyrin (TB) at concentrations of 500 mg/kg (T1 group) and 1000 mg/kg (T2 group), respectively. Cloning yielded a 2364 bp open reading frame (ORF) encoding 787 amino acids, with the gene possessing two conserved transmembrane domains. Phylogenetic analysis further indicated a close phylogenetic relationship between largemouth blackbass () and mandarin fish. Tissue distribution and intestinal enzyme activity analyses revealed that supplementation with varying concentrations of TB upregulates gene expression in different tissues, while modulating intestinal digestive enzyme and antioxidant enzyme activities. Our findings suggest a potential mechanism involving enhanced intestinal enzyme activity, reduced fat accumulation, increased expression of lipid oxidation-related genes, and accelerated TB degradation in the intestine. - Source: PubMed
Publication date: 2026/03/12
Xu Er-XueGuo YiXu Yi-HuanBao Teng-FeiWu Cheng-BinGao Xiao-WeiGong Chun-Guang - Rheumatoid arthritis (RA) is a chronic autoimmune rheumatic disease of unknown etiolgy, characterized by erosive polyarthritis that leads to joint destruction and systemic inflammatory lesions in internal organs. Pain is a primary symptom of RA and a major contributor to psychological disturbances, which influence patients' subjective evaluation of their condition. These psychological issues may stem from disruptions in central pain regulation mechanisms, such as central sensitization (CS), which can also affect central metabolic processes. The objective was to investigate how the severity of central sensitization, measured by the Central Sensitization Inventory (CSI) questionnaire (Part 1), impacts clinical and neuropsychiatric parameters, as well as the expression of genes related to inflammation, tissue destruction, carbohydrate metabolism, and fatty acid metabolism in peripheral blood mononuclear cells (PBMCs) in patients with RA. Methods involved collecting blood samples from 59 RA patients (mean age 52.0 years). Clinical status was assessed using the DAS28 index and serum levels of CRP, ASPA, and RF. Neuropsychiatric parameters were evaluated through questionnaires measuring CS severity score (CSI), pain intensity (VAS, BPI), neuropathic pain (PainDETECT), anxiety and depression (HADS), fatigue (FSS, FACIT-F), fibromyalgia symptoms (FIRST), and pain catastrophizing. Protein expression in PBMCs was measured by ELISA, while gene expression was analyzed using quantitative real-time RT-PCR. All patients exhibited moderate to high disease activity. Participants were divided into four subgroups according to their CSI scores: subclinical (0-29 points), mild (30-39 points), moderate (40-49 points), and severe/extreme (50-100 points). Higher CSI scores correlated with significant increases in neuropsychiatric symptoms and a notable decrease in vitality. However, clinical parameters showed no significant differences among the subgroups. Gene expression analysis revealed upregulation of genes involved in the pentose phosphate pathway (G6PD), antioxidant defense (SOD1), fatty acid metabolism (FASN, CPT1B), apoptosis (CASP3), and tissue destruction and hypernociception (MMP-9) compared to healthy controls. The pro-inflammatory cytokine IL-1β expression was comparable to controls, while TNFα expression was elevated only in patients with severe/extreme CS scores. These findings suggest that CS-related disturbances may contribute to increased disease severity in RA, even in patients receiving active antirheumatic treatment. At the cellular level, disease severity appears linked to dysregulated expression of genes governing central metabolic processes, despite low expression of pro-inflammatory cytokine genes. - Source: PubMed
Publication date: 2026/03/22
Tchetina ElenaPotapova AlenaVienozinskaite AngeleGlukhova SvetlanaCherkasova MariaFilatova EkaterinaKarateev AndreyLila Aleksandr - Skeletal muscle myogenesis is a crucial factor influencing meat production in livestock. MicroRNAs (miRNAs) play a significant role in skeletal muscle myogenesis. The objective of this study was to identify key miRNAs involved in the process of goat skeletal muscle satellite cell (MuSC) differentiation into myotubes. We performed miRNA expression profiling analysis during the proliferation phase (cultured in growth medium, GM) and the differentiation phase (cultured in differentiation medium for 1 day and 5 days, classified as DM1 and DM5, respectively) of goat skeletal muscle satellite cells (MuSCs). A total of 1846 miRNAs were identified in MuSC samples, of which 677 differentially expressed miRNAs (DEmiRNAs) were screened through pairwise comparisons across three groups (GM vs. DM1, GM vs. DM5, and DM1 vs. DM5), and the results were further confirmed by a quantitative real-time PCR assay. Time-series expression profiling facilitated the categorization of the DEmiRNAs into eight distinct clusters, one of which demonstrated a significantly downregulated expression pattern ( < 0.05). Functional enrichment analysis revealed that the target genes of DEmiRNAs are involved in several pathways that are critical for myogenesis, including Hippo, TGF-β, MAPK and cell adhesion molecules. Interaction network analysis identified 19 miRNAs and 56 mRNAs associated with muscle cell development. Notably, novel-m0047-5p emerged as a key regulator, exhibiting strong negative correlations (r = -0.88 to -0.89, q < 0.01) with muscle-related target genes FOSB, CPT1B, and MYOZ2. These findings elucidate miRNA-mediated regulatory networks in goat myogenesis and provide candidate molecular targets for genetic improvement of meat production traits. - Source: PubMed
Publication date: 2026/03/13
Luo RunxiaoZhong TaoWang LinjieYang ShizhongLi LiZhang HongpingZhan Siyuan