Ask about this productRelated genes to: INSIG1 antibody
- Gene:
- INSIG1 NIH gene
- Name:
- insulin induced gene 1
- Previous symbol:
- -
- Synonyms:
- CL-6, MGC1405
- Chromosome:
- 7q36.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-05-15
- Date modifiied:
- 2016-10-05
Related products to: INSIG1 antibody
Related articles to: INSIG1 antibody
- Mitochondrial metabolism (MM) abnormalities have been implicated in multiple diseases, but its contribution to sepsis-associated encephalopathy (SAE) remains insufficiently understood. The purpose of this research was to explore the candidate biomarkers associated with MM in SAE and the underlying mechanisms. - Source: PubMed
Publication date: 2026/05/22
Zhou RanFang HaoLi HeruiZhang YunhuiSu Xiaosan - Acute kidney injury (AKI) is characterized by a rapid decline in renal function, often associated with tubular cell death. Insulin-induced gene 1 (Insig1), a key regulator of cholesterol metabolism, has not been previously implicated in AKI pathogenesis. - Source: PubMed
Publication date: 2026/05/16
Cao ShihanWang QianZhou MengyuSun ZhenzhenSun LeZhu WenpingWang XuHuang SongmingZhang AihuaHua HuDing GuixiaZhang YueJia Zhanjun - Human milk is a bioactive fluid containing maternal leukocytes that support infant immune protection and development. Prior work has demonstrated the presence of atypical, non-granulocyte milk myeloid cells that do not conform to previously-defined cell subsets. To assess the true diversity of mononuclear milk myeloid cells, we performed single-cell RNA sequencing (scRNAseq) on >23,000 CD45 ⁺ enriched cells from 9 healthy lactating donors. Clustering identified 18 transcriptionally distinct mononuclear myeloid subpopulations, including 10 macrophage clusters, 5 dendritic cell subsets, 1 monocyte population, and 2 epithelial-like clusters. Macrophages segregated into M1-like and M2-like states exhibiting discrete transcriptional programs. The epithelial-like clusters expressed both epithelial markers (e.g., EPCAM, KRT19, CLDN3) and myeloid genes, suggesting phagocytic activity or hybrid states. Numerous myeloid sub-clusters exhibited transcriptional features consistent with adaptation to the lipid-rich environment of milk, supported also by reactome data. This included LDL and lipoprotein clearance pathways and expression of genes such as INSIG1 and QSOX1 in monocytes and APOE, LIPA, and APOC1 in macrophages. Signaling pathways were also dominated by degranulation and IL-4/10/13 activities, as well as antigen presentation programs. CellChat analysis revealed extensive intercellular communication among myeloid subsets involving MHC-II, SPP1, and MIF, consistent with active antigen presentation and tissue remodeling. Notably, pronounced donor-specific heterogeneity was observed, with several sub-clusters restricted to 1-2 individuals, underscoring personalized immune composition during lactation. These data indicate that milk myeloid cells are not merely passively transported immune cells but actively shaped and diversified by the lactational niche, and establish a high-resolution framework for future studies. - Source: PubMed
Publication date: 2026/05/11
Schrode NadineYang XiaoqiFox AlisaChowhan DishaDeCarlo ClaireBeaumont KristinPowell Rebecca L R - This study aimed to investigate whether mixed heavy metal exposure (lead, cadmium, manganese, and arsenic) during pregnancy induces gestational diabetes mellitus (GDM)-like phenotypes and to explore the associated molecular alterations. We examined the effects of exposure on metabolic disturbances using a Sprague-Dawley rat model exposed to low- and high-dose mixed heavy metals, with doses selected based on biomonitoring data. The results showed that high-dose mixed heavy metal exposure significantly increased blood glucose levels in rats, elevated the area under the curve (AUC) during the oral glucose tolerance test (OGTT), and induced insulin resistance and dyslipidemia. Concurrently, pathological examinations revealed hepatocyte steatosis, inflammatory cell infiltration, and mitochondrial abnormalities in liver tissues. Transcriptomic and metabolomic analyses identified significant disruption of the glycerophospholipid metabolic pathway following heavy metal exposure, suggesting the involvement of this pathway in the observed metabolic disturbances. Lasso regression analysis identified Insig1 as a candidate gene associated with lipid metabolic alterations, a finding subsequently validated by qPCR. Overall, mixed heavy metal exposure during pregnancy was associated with GDM-like metabolic abnormalities in rats. Disruption of glycerophospholipid metabolism and altered Insig1 expression likely contribute to these effects, providing molecular evidence linking mixed heavy metal exposure to gestational metabolic dysfunction. - Source: PubMed
Publication date: 2026/04/21
Sun TianaoZheng ZhanyueMa YongjiePan MinglianZhou YingjieWei JingxiaYuan XinyuWan JinhaoLi YouSun Yan - The stems and leaves of (CPSL) are commonly treated as agricultural waste, yet they are rich in antioxidants and other bioactive compounds. In order to explore their applicability in livestock feeding, a systematic evaluation was conducted on the dose-dependent effects of CPSL on yak production traits and meat characteristics. A total of forty yaks were randomly allocated into four experimental groups, including a control group fed a basal diet and three treatment groups receiving the basal diet supplemented with 0.5%, 1.0%, or 2.0% CPSL. Results indicated that the 2.0% CPSL supplementation group exhibited the highest net meat yield while significantly improving meat processing suitability. Through transcriptomic profiling, 13 genes were found to be differentially expressed between the control and CPSL-treated groups, with functions related to myofiber formation and energy metabolic processes. A marked upregulation of insulin-sensitizing gene 1 (INSIG1) and arginase 2 (ARG2) was observed specifically in the group receiving the intermediate CPSL dose. Metabolomic profiling further revealed that 81 shared differentially abundant metabolites were primarily involved in the AMPK signaling and oxidative phosphorylation pathways. Collectively, CPSL not only fortifies yak beef production by optimizing growth and slaughter performance but also significantly enhances meat tenderness and processing adaptability through regulating core mechanisms governing redox hubs and energy metabolism. These findings offer novel insights into the high-value utilization of CPSL as a feed additive. - Source: PubMed
Publication date: 2026/04/03
Yang XueLi YihengShen RuhengDuan YufengSong RendeShi HongmeiKong XiangyingHua YongliZhang WangangZhang Li