Ask about this productRelated genes to: MARCO antibody
- Gene:
- MARCO NIH gene
- Name:
- macrophage receptor with collagenous structure
- Previous symbol:
- -
- Synonyms:
- SCARA2, SR-A6
- Chromosome:
- 2q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-26
- Date modifiied:
- 2017-02-28
Related products to: MARCO antibody
Related articles to: MARCO antibody
- - Source: PubMed
Publication date: 2026/04/25
Kayser Georgia LZhang JasenBaghdad AzarakhashWei JennyChronister Briana N CCalderón-Villarreal AlhelíBrouwer Kimberly CSuarez-Torres JoseDe La Cruz FranklinSuarez-Lopez Jose R - To examine changes in monocyte subpopulations and surface markers in people with obesity before and after bariatric surgery, and their relation to weight loss, inflammation markers, and comorbidities. - Source: PubMed
Publication date: 2026/04/24
Krasselt MarcoFriedrich KathleenBraune LaurinRothe KathrinBlüher MatthiasKovacs PeterDietrich ArneRossol ManuelaStumvoll MichaelWagner Ulf - - Source: PubMed
Publication date: 2026/04/25
Ribas Maria PuigAguilar Xavier FernándezEspunyes JohanCarrera-Faja LauraPailler-García LolaMarco IgnasiCabezón Oscar - Suppressor/enhancer of Lin-12-like (SEL1L) is a component of the endoplasmic reticulum-associated degradation (ERAD) pathway which is part of the unfolded protein response (UPR). SEL1L may exert pro-tumorigenic or oncosuppressive functions in different tumor types, but its role in human cutaneous malignant melanoma (cMM) remains largely unexplored. Here, in silico analysis revealed that SEL1L is upregulated in cMM compared to normal skin. In addition, SEL1L expression in cMM positively correlated with Clark level at diagnosis, higher expression being associated with poorer patient survival. SEL1L co-expression with ERAD- and UPR-related genes, along with Gene Ontology enrichment analysis, supported its role in ER-stress responses in cMM. Immunohistochemistry and quantitative digital morphometric analysis of SEL1L protein levels in 60 human samples of benign melanocytic tumors and cMMs at different Breslow T category showed that SEL1L levels in cMM progressively increase in association with T category, tumor thickness, and the presence of ulceration. In addition, total and tumor-associated endothelial SEL1L expression correlates with microvessel density in the corresponding tumor specimens. In keeping with a non-redundant role of SEL1L in cMM, grafting of SEL1L-silenced A2058 human melanoma cells in immunodeficient mice yielded tumors with reduced cell proliferation, enhanced apoptosis, and increased necrosis, accompanied by heightened hypoxia and reduced vascularization. Accordingly, SEL1L-silenced cells showed upregulation of the angiosuppressive thrombospondin-encoding genes THSP1 and THSP2 and a reduced angiogenic potential in an endothelial sprouting assay in vitro and in the chick embryo chorionallantoic membrane assay in vivo. Together, these findings indicate that SEL1L may exert a pro-tumorigenic/pro-angiogenic function in human melanoma and pave the way to further studies aimed at investigating its potential as a therapeutic target in cMM. - Source: PubMed
Publication date: 2026/04/22
Coltrini DanielaBelleri MirellaMignani LucaCorli MarziaCazzato GerardoTurati MartaRibatti DomenicoPresta MarcoAnnese Tiziana - A new putative taxon of the Anopheles gambiae complex - genetically related to the two main malaria vector species of the complex, An. gambiae and An. coluzzii - was recently described at the westernmost extremes of the two species' range based on WGS data from The MalariaGEN Vector Observatory, and named BISSAU molecular form. This was found resting in human dwellings, in sympatry with An. gambiae and An. coluzzii and to be characterized by a unique ancestral gene pool and a complex demographic history. We here present the results of population genomic analyses (PCA, ADMIXTURE, TreeMix, unrooted neighbour-joining tree, and TESS3R) based on >200 K SNPs on chromosome-3 obtained exploiting WGS data from 2,283 An. coluzzii, An. gambiae, An. arabiensis, An. melas and BISSAU molecular form specimens collected between 2005 and 2021 at 35 locations across The Gambia. Results consistently identify BISSAU molecular form as a genetically discrete, temporarily stable unit within a sister clade with An. gambiae and An. coluzzii, showing no signs of admixture with any of the sympatric members of the An. gambiae complex. This strongly supports the BISSAU form as an independently evolved lineage reproductively isolated from other sympatric members of the An. gambiae complex. The north bank of Gambia river, from about 10 to 120 km from the seacoast, has the higher probability of occurrence of BISSAU molecular form. In this area, breeding sites are mainly characterized by brackish and fresh water associated with large flooded swamp areas with alluvial deposits in close proximity to the river and its tributaries. - Source: PubMed
Publication date: 2026/04/22
De Marco Carlo MariaCaputo BeniaminoPichler VerenaHamid-Adiamoh MajidahGibba BallaClarkson ChrisAssogba Benoit SessinouD'Alessandro UmbertoAmambua-Ngwa AlfredTorre Alessandra Della