Ask about this productRelated genes to: GGTL3 antibody
- Gene:
- GGT7 NIH gene
- Name:
- gamma-glutamyltransferase 7
- Previous symbol:
- GGTL5, GGTL3
- Synonyms:
- D20S101, dJ18C9.2
- Chromosome:
- 20q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-04
- Date modifiied:
- 2016-07-28
Related products to: GGTL3 antibody
Related articles to: GGTL3 antibody
- Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance across multiple solid tumors. However, the comprehensive landscape of the GGT gene family and its clinical value in tumor diagnosis and prognosis remain unclear. - Source: PubMed
Wang FeiYang JianshanZhu FengXu XuebingZhao JunpengXie XudongHe XuyangHuang YuxuanZhou LirongHu XiaogangLu XiaominXiao Mingbing - Undifferentiated spindle cell sarcoma (USCS) is a rare and heterogeneous group without specific diagnostic, prognostic, or predictive markers. The clinicopathologic and proteomic characteristics of USCS remain largely unknown. - Source: PubMed
Publication date: 2025/07/01
Wei YaniLi HongjunHe ShujinLi MinChen YongyuShi HuijuanHan Anjia - Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling the molecular basis of lipid or cholesterol homeostasis would help to identify novel drug targets and develop effective therapeutics. - Source: PubMed
Publication date: 2025/03/17
Shan HaihuanFan ShuangshuangLi QuanrunLiang RuipuChen ZhisongWang ShengnanWang XiaofengLi YurongChen ShuaiYu KunFei Teng - The human gamma-glutamyltransferase (GGT) is a membrane-bound extracellular glycoprotein with an enzymatic activity that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. It has been shown aberrant expression of GGT proteins in human cancers while their expression profiles in prostate cancers are not reported. - Source: PubMed
Publication date: 2025/02/28
Jiang WencongLiu WangZhao JiangXu ZhijianXi MingWang XiangweiLi Benyi - Thermal condition affects the development and growth of ectotherms. The stenothermic honeybee brood, particularly the prepupae, are sensitive to low rearing temperature. The fat body plays important roles in energy reserve and metabolism during the honeybee brood development. To date, the fat body metabolic changes in prepupae responding to cold stress have not been completely understood. In this study, the ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS)-based non-target metabolome was analyzed between the cold-treated (CT, 20 °C, 36 h) and control (CK, 35 °C) fat body in prepupal honeybees. The fat body metabolomic data showed that the levels of 1860 and 254 metabolites were significantly increased and decreased, respectively, in cold-stressed prepupae. These altered metabolites, glutamine, glutamic acid, pyroglutamic acid, and oxidized glutathione, were significantly enriched into glutamine metabolism and glutathione metabolism pathways. Furthermore, the expression levels of glutamine metabolism-related genes, (), (), and ( and ), were significantly decreased in cold-exposed prepupae compared with the control groups. Meanwhile, the oxidized glutathione (GSSG), but not the reduced glutathione (GSH) content, was increased in the cold-exposed group compared with controls. Collectively, our data revealed the fat body metabolomic changes in larva-to-pupa transition when exposed to cold stress. Our data provided new insights into stenothermic honeybee sensitivity to cold, characterized by perturbation of glutamine metabolism and oxidative stress. - Source: PubMed
Publication date: 2025/01/02
Xu XinjianCao MingjieZhu ChenyuMo LingqingHuang HuajiaoXie JiayingZhou BingfengZhou ShujingZhu Xiangjie