Ask about this productRelated genes to: GGTL3 antibody
- Gene:
- GGT7 NIH gene
- Name:
- gamma-glutamyltransferase 7
- Previous symbol:
- GGTL5, GGTL3
- Synonyms:
- D20S101, dJ18C9.2
- Chromosome:
- 20q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-04
- Date modifiied:
- 2016-07-28
Related products to: GGTL3 antibody
Related articles to: GGTL3 antibody
- Ageratum conyzoides Linn. is a promising candidate for multi-metal remediation. This study examined the rhizosphere microecology and molecular regulation of A. conyzoides under Cd, Pb, and Zn co-stress after 21 and 50 days of exposure. The ethanol-extracted fraction was found to be the predominant form of Cd, Pb, and Zn in the roots, whereas the NaCl-, HCl-, and HAc-extracted fractions prevailed in the shoots. Heavy metals were mainly distributed in the cell wall and soluble fractions. Metabolome and microbiome analyses revealed dynamic changes in rhizosphere exudate metabolic profiles and bacterial community composition in the rhizosphere soil after 21 and 50 days of exposure to stress. After 21 days of stress, increased exudation of oxalic acid, L-valine, and L-glutamate was correlated with the enrichment of Clostridium_sensu_stricto_12 and norank_p_FCPU426. After 50 days of stress, significantly increased exudation of jasmonic acid, gibberellin A24, and 4-hydroxynonenal was correlated with the enrichment of Bauldia, Candidatus_Udaeobacter, and norank_f_Anaerolineaceae. Transcriptome analysis revealed that prolonged stress upregulated the expression of SEC61A2, Uggt, Ggt7, gss, and PRX1 in A. conyzoides leaves; the differentially expressed genes were found to be significantly enriched in the protein processing in the endoplasmic reticulum pathway and glutathione metabolic pathway. Overall, these findings provide a theoretical foundation for optimizing phytoremediation using A. conyzoides. - Source: PubMed
Publication date: 2026/07/22
Fu YuexinChen MouyixingZhang XuehongYu GuoJiang PingpingLiu JieYou Shaohong - Serum gamma-glutamyltransferase (GGT) is a biomarker for cardiovascular disease, but the role of its encoding gene family in ischemic stroke (IS) is unknown. This pilot study of 1288 individuals (600 cases and 688 controls) investigated , , , and polymorphisms using the MassARRAY-4 system. Conventional single-variant, haplotype, and diplotype analyses were complemented by Model-Based Multifactor Dimensionality Reduction (MB-MDR) with stability assessment and model prioritization. Conventional analysis identified female-specific associations for three variants (rs8140505, rs2275984, and rs2267073; P < 0.05). A common haplotype was protective in females (P = 0.02). Diplotype analysis revealed joint effects of GGT genotypes on IS risk in females (FDR < 0.05). MB-MDR uncovered complex higher-order interactions (P < 0.0001): in women, 12 models represented second-order interactions between smoking and individual GGT variants. In men, 8 models centered on rs5751909 spanning second- to fourth-order interactions with alcohol, smoking, and other GGT family members. All prioritized models passed FDR correction (q < 0.05) and achieved higher weighted composite scores. eQTL data linked these variants to regulatory networks controlling glutathione metabolism, oxidative stress, and inflammation. This study supports a novel hypothesis on the combined involvement of GGT gene family polymorphisms and pro-oxidant environmental factors in ischemic stroke predisposition, demonstrating that disease risk is shaped by sex-specific gene-environment interactions. The pronounced sexual dimorphism highlights the need for sex-specific personalized approaches: smoking cessation may be particularly impactful in women carrying risk variants, while alcohol moderation could be prioritized in men with risk variants. - Source: PubMed
Publication date: 2026/04/24
Solodilova MariaDrozdova ElenaAzarova IuliiaBykanova MarinaBushueva OlgaPuchkova AnnaPuchkov VyacheslavFreidin MaximChurnosov MikhailPolonikov Alexey - Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in glutathione metabolism and oxidative stress regulation. Although it is traditionally viewed as a liver function marker, emerging evidence suggests that its aberrant expression is closely associated with tumorigenesis, progression, and therapeutic resistance across multiple solid tumors. However, the comprehensive landscape of the GGT gene family and its clinical value in tumor diagnosis and prognosis remain unclear. - Source: PubMed
Wang FeiYang JianshanZhu FengXu XuebingZhao JunpengXie XudongHe XuyangHuang YuxuanZhou LirongHu XiaogangLu XiaominXiao Mingbing - Undifferentiated spindle cell sarcoma (USCS) is a rare and heterogeneous group without specific diagnostic, prognostic, or predictive markers. The clinicopathologic and proteomic characteristics of USCS remain largely unknown. - Source: PubMed
Publication date: 2025/07/01
Wei YaniLi HongjunHe ShujinLi MinChen YongyuShi HuijuanHan Anjia - Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling the molecular basis of lipid or cholesterol homeostasis would help to identify novel drug targets and develop effective therapeutics. - Source: PubMed
Publication date: 2025/03/17
Shan HaihuanFan ShuangshuangLi QuanrunLiang RuipuChen ZhisongWang ShengnanWang XiaofengLi YurongChen ShuaiYu KunFei Teng