Ask about this productRelated genes to: ACPL2 antibody
- Gene:
- PXYLP1 NIH gene
- Name:
- 2-phosphoxylose phosphatase 1
- Previous symbol:
- ACPL2
- Synonyms:
- FLJ23751
- Chromosome:
- 3q23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-16
- Date modifiied:
- 2014-03-17
Related products to: ACPL2 antibody
Related articles to: ACPL2 antibody
- HOXB8 is implicated in various cancers. However, the effect pattern of HOXB8 in head and neck squamous cell carcinoma (HNSCC) remains unclear. - Source: PubMed
Publication date: 2025/04/30
Zhang Jun-WeiGao Xi-LinWang JingFan Xue-LiLiang Qi-Wei - Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable. - Source: PubMed
Publication date: 2022/09/10
Schrott RoseModliszewski Jennifer LHawkey Andrew BGrenier CaroleHolloway ZadeEvans JanequiaPippen EricaCorcoran David LLevin Edward DMurphy Susan K - Tumor mutation burden (TMB) is considered as a novel biomarker of response to immunotherapy and correlated with survival outcomes in various malignancies. Here, TMB-related genes (TRGs) expression signatures were constructed to investigate the association between TMB and prognosis in epithelial ovarian cancer (EOC), and the potential mechanism in immunoregulation was also explored. Based on somatic mutation data of 436 EOC samples from The Cancer Genome Atlas database, we examined the relationship between TMB level and overall survival (OS), as well as disease-free survival (DFS). Next, the TRGs signatures were constructed and validated. Differential abundance of immune cell infiltration, expression levels of immunomodulators and functional enrichment in high- and low-risk groups were also analyzed. Higher TMB level revealed better OS and DFS, and correlated with earlier clinical stages in EOCs ( = 2.796e-04). The OS-related prognostic model constructed based on seven TRGs ( and ) significantly stratified EOC patients into high- and low-risk groups ( 0.001). The AUC values of the seven-gene prognostic signature at 1 year, 3 years, and 5 years were 0.703, 0.758 and 0.777. While the DFS-related prognostic model was constructed based on the 4 TRGs ( and ), with AUCs of 0.617, 0.756, and 0.731, respectively. Functional analysis indicated that immune-related pathways were enriched in low-risk groups. When considering the infiltration patterns of immune cells, we found higher proportions of follicular helper T (Tfh) cell and M1 macrophage, while lower infiltration of M0 macrophage in low-risk groups ( < 0.05). Accordingly, TMB levels of low-risk patients were significantly higher both in OS and DFS model ( < 0.01). Our TRGs-based models are reliable predictive tools for OS and DFS. High TMB may confer with an immunogenic microenvironment and predict favorable outcomes in EOCs. - Source: PubMed
Publication date: 2020/10/23
Liu JinhuiXu WeiLi SiyueSun RuiCheng Wenjun - Recently, we demonstrated that FAM20B is a kinase that phosphorylates the xylose (Xyl) residue in the glycosaminoglycan-protein linkage region of proteoglycans. The phosphorylation of Xyl residues by FAM20B enhances the formation of the linkage region. Rapid dephosphorylation is probably induced just after synthesis of the linker and just before polymerization initiates. Indeed, in vitro chondroitin or heparan sulfate polymerization does not occur when the Xyl residue of the tetrasaccharide linkage region is phosphorylated. However, the enzyme responsible for the dephosphorylation of Xyl remains unknown. Here, we identified a novel protein that dephosphorylates the Xyl residue and designated it 2-phosphoxylose phosphatase. The phosphatase efficiently removed the phosphate from the phosphorylated trisaccharide, Galβ1-3Galβ1-4Xyl(2-O-phosphate), but not from phosphorylated tetrasaccharide, GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate). Additionally, RNA interference-mediated inhibition of 2-phosphoxylose phosphatase resulted in increased amounts of GlcNAcα1-4GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate), Galβ1-3Galβ1-4Xyl(2-O-phosphate), and Galβ1-4Xyl(2-O-phosphate) in the cells. Gel filtration analysis of the glycosaminoglycan chains synthesized in the knockdown cells revealed that these cells produced decreased amounts of glycosaminoglycan chains and that the chains had similar lengths to those in the mock-transfected cells. Transcripts encoding this phosphatase were ubiquitously, but differentially, expressed in human tissues. Moreover, the phosphatase localized to the Golgi and interacted with the glucuronyltransferase-I involved in the completion of the glycosaminoglycan-protein linkage region. Based on these findings, we conclude that transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region controls the formation of glycosaminoglycan chains of proteoglycans. - Source: PubMed
Publication date: 2014/01/14
Koike ToshiyasuIzumikawa TomomiSato BanKitagawa Hiroshi