Ask about this productRelated genes to: FAM19A3 antibody
- Gene:
- TAFA3 NIH gene
- Name:
- TAFA chemokine like family member 3
- Previous symbol:
- FAM19A3
- Synonyms:
- TAFA-3
- Chromosome:
- 1p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-17
- Date modifiied:
- 2019-01-14
Related products to: FAM19A3 antibody
Related articles to: FAM19A3 antibody
- TAFA chemokine like family member 4 (TAFA4, also named FAM19A4) is a member of the TAFA chemokine like ligand or FAM19A family, which includes TAFA1, TAFA2, TAFA3, TAFA4, and TAFA5 (or FAM19A1, FAM19A2, FAM19A3, FAM19A4, and FAM19A5). They are also referred to as neurokines and are involved in the regulation of a diverse range of cellular processes, including chemotaxis of macrophages, phagocytosis, and release of reactive oxygen species (ROS). TAFA4 is a marker of C-low-threshold mechanoreceptors and is expressed predominantly in nociceptors, such as dorsal root ganglia (DRG). TAFA4 has been implicated in the sensory perception of pain in the spinal cord. Mice with deficiency of TAFA4 demonstrate altered excitability in lamina IIi neurons in DRG in addition to increased mechanical and chemical nociception following inflammation or injury. As a secreted protein, TAFA4 binds to cell surface receptor formyl peptide receptor 1 (FPR1), a G protein-coupled receptor to mediate the chemoattraction of macrophages, phagocytosis, and the inflammatory profile of macrophages. It also interacts with cell surface neurexin to mediate signalling across the synapse. Further understanding the mechanisms by which this conserved protein family regulates diverse biological processes such as in neuronal functions, inflammation, and tissue fibrosis will help to design therapeutic targets for the treatment of TAFA related diseases such as spinal cord injury and neuro-inflammatory disorders. - Source: PubMed
Publication date: 2022/05/31
Zhu SipinHu XiaoyongBennett SamuelMai YuliangXu Jiake - In this study, we have identified FAM19A3 as a gene that is significantly upregulated in the microglia in the middle cerebral artery occlusion (MCAO) mouse model. FAM19A3 expression and secretion were promoted by M2 stimuli, and this indicated that FAM19A3 might be an M2-type gene. Indeed, recombinant FAM19A3 promoted M2 polarization and inhibited M1 polarization of microglia in vitro. Similarly, recombinant FAM19A3 promoted M2 polarization of microglia and macrophages in vivo, and attenuated cerebral ischemia in the MCAO mouse model. Thus, the newly-identified secreted protein FAM19A3 modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. - Source: PubMed
Publication date: 2015/01/13
Shao YankunDeng TingZhang TongLi PeilanWang Yuehui - The hypophysial pars tuberalis (PT) is an important interface between neuroendocrine brain centers (hypothalamus, pineal organ) and the anterior lobe of the hypophysis (PD). The best investigated role of the PT is the control of seasonally changing functions. In mammals, melatonin secreted from the pineal organ represents a major input signal to the PT. By acting upon melatonin type 1 receptors (MT1) melatonin controls the functional activity of the PT. Most interestingly, the PT sends its output signals in two directions: via a "retrograde" pathway to the hypothalamus and via an "anterograde" pathway to the PD. TSH has been identified as "retrograde" messenger, while endocannabinoids function as messengers of the "anterograde" pathway. Here we show in mice that the PT expresses Tafa-3 encoding for a secretory peptide. In the PT of wild type mice Tafa-3 mRNA levels varied between day and night: they were low at mid-day and high at mid-night. This day/night difference was not observed in the PT of mice with a targeted deletion of the MT1 receptor indicating that Tafa-3 mRNA expression in the PT is controlled by melatonin acting through the MT1 receptor. Notably, Tafa-3 expression was not restricted to the PT, but was also found in other brain regions, such as the hippocampus, the habenular and thalamic nuclei. In these regions, Tafa-3 expression did not display a day/night difference and was not affected by MT1-deficiency. Thus, Tafa-3 expression appears to be controlled by region-specific mechanisms. Our data suggest that TAFA-3 is a signaling molecule from the PT and provides further evidence for the emerging concept that the PT rather than relying upon highly organ-specific messengers employs a cocktail of signaling molecules that also operate in other brain systems. - Source: PubMed
Publication date: 2012/03/07
Fischer ClaudiaChrist ElmarKorf Horst-Wernervon Gall Charlotte - We have discovered a family of small secreted proteins in Homo sapiens and Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues. - Source: PubMed
Tom Tang YEmtage PeterFunk Walter DHu TianhuaArterburn MatthewPark Emily E JRupp Fabio