Ask about this productRelated genes to: MARVELD3 antibody
- Gene:
- MARVELD3 NIH gene
- Name:
- MARVEL domain containing 3
- Previous symbol:
- MRVLDC3
- Synonyms:
- -
- Chromosome:
- 16q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-15
- Date modifiied:
- 2014-11-19
Related products to: MARVELD3 antibody
Related articles to: MARVELD3 antibody
- The pervasive environmental presence of nano- and microplastics, particularly polystyrene nanoplastics (PSNPs), has raised increasing concern regarding their potential adverse effects on human health. While epithelial barrier impairment is recognized as a critical toxicological outcome, the oral epithelium remains a poorly understood target despite being the primary gateway for ingested nanoplastics. In this study, we demonstrate that PSNPs induce significant functional impairment of the oral barrier even under sub-cytotoxic conditions (>80% cell viability). Exposure of TR146 human buccal epithelial cell layers to PSNPs triggered an early increase in paracellular permeability (fluorescein isothiocyanate-labeled dextran (4 kDa) flux), followed by a decline in transepithelial electrical resistance. Crucially, these functional deficits occurred in the absence of overt cytotoxicity and were associated with the molecular downregulation and altered distribution of tight junction-related proteins, including ZO-2, occludin, MarvelD3, and claudin-3 and claudin-4. Our findings indicate that PSNP-induced alterations in TJ-related protein distribution may represent an early molecular event associated with oral epithelial barrier dysfunction under sub-cytotoxic conditions. Collectively, this study highlights the oral epithelium as a highly sensitive target and underscores that functional barrier failure, rather than direct cytotoxicity, may represent a key mechanism underlying nanoplastic-associated toxicity. - Source: PubMed
Publication date: 2026/05/02
Park Ha-YoungShin Soo-Bin - Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by obsessions and compulsions, with a prevalence of 1%-3%. Tight junction (TJ) proteins contribute to maintaining the epithelial barrier. This study investigated the association of serum TJ-associated MARVEL protein family and inflammatory markers with OCD severity in children and adolescents. - Source: PubMed
Publication date: 2026/03/31
Ünal KübranurTorun Yasemin TaşErol Mehmet EmreKurt Zeynep KübraÖzbaş Cansu - In modern swine breeding, there has been a shift from maximizing productivity to improving quality to enhance overall efficiency. A key goal is achieving a balance between litter size and piglet birth weight. This study focused on Danish Large White pigs and aimed to evaluate a novel placental efficiency (PEA) index based on placental area (PA) as a biologically relevant and measurable trait for breeding programs. - Source: PubMed
Publication date: 2026/04/02
Yu ShiXinCui ShengDiChen DongZhao ZhenJianTecku Patrick Kofi MakafuiChen JiaMiaoHuang RunJieZhou YaoXiTang GuoQing - Esophageal cancer (ESCA) carries a poor prognosis, and the exploration of mRNA vaccines for its treatment remains limited. This study aims to identify potential tumor antigens and characterize the immune landscape, thereby providing a foundation for developing mRNA vaccines against ESCA. - Source: PubMed
Publication date: 2025/11/26
Zhang ZeweiHou JixiangWang YingxueJiang YingWang WenjuanZhao JuanJin GaowaZhao LeiLi Quanfu - Tight junction proteins have been implicated in the progression of various diseases. MarvelD3, a member of the MARVEL domain protein family involved in tight junction formation, exhibits diverse expression patterns and functions across different tissues. However, its specific role in esophageal squamous cell carcinoma (ESCC) remains to be elucidated. This study demonstrated that MarvelD3 is significantly overexpressed in ESCC tissues. Furthermore, the knockdown of MarvelD3 enhances the radiosensitivity of ESCC in both in vitro and in vivo models. RNA-sequencing analysis identified Interferon alpha inducible protein 6 (IFI6) as a target of MarvelD3. Co-immunoprecipitation assays revealed an interactive regulatory relationship between MarvelD3 and MYB. Additionally, dual-luciferase reporter gene assays and chromatin immunoprecipitation assays confirmed that MYB directly binds to the promoter of the IFI6 gene, thereby regulating IFI6 transcription. Collectively, these findings suggest that MarvelD3 plays a critical role in modulating the radiosensitivity of ESCC via the MYB/IFI6 axis, uncovering a promising mechanism underlying the pathogenesis and progression of ESCC. - Source: PubMed
Publication date: 2025/11/28
Wang XiCao JinmingZhou KaixiaoGe YangyangZhu WeiZhang QiJiao YangCao Jianping