Ask about this productRelated genes to: POPDC3 antibody
- Gene:
- POPDC3 NIH gene
- Name:
- popeye domain containing 3
- Previous symbol:
- -
- Synonyms:
- POP3, MGC22671, bA355M14.1
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-08
- Date modifiied:
- 2014-11-19
Related products to: POPDC3 antibody
Related articles to: POPDC3 antibody
- Popeye domain containing 3 () gene encodes a protein involved in membrane trafficking and is highly expressed in skeletal muscles. pathogenic variants are associated with LGMDR26. Only a few reports of POPDC3 LGMD exist worldwide and none from India. Herein, we describe the first case of POPDC3 LGMD26. - Source: PubMed
Publication date: 2025/09/30
Baskar DiptiPolavarapu KiranKotambail AnanthapadmanabhaArunachal GauthamTumulu Seetam KumarKotra MadhulikaGowda DarshanNalini AtchayaramVengalil Seena - The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb-girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26. At the animal level, zebrafish larvae with popdc3 mutations develop tail curls and muscle atrophy. However, the mechanism of skeletal muscle atrophy induced by POPDC3 variants/loss remains unclear. - Source: PubMed
Sun Chen-ChenChen Zhang-LinYang DongXiao Jiang-LingChen Xiang-TaoPeng Xi-YangWu Xiu-ShanTang Chang-Fa - The tumor microenvironment (TME) is pivotal in non-small cell lung cancer (NSCLC) progression, influencing drug resistance and immune cell behavior through complex ligand-receptor (LR) interactions. This study developed an epithelial LR-related prognostic risk score (LRrisk) to identify biomarkers and targets in NSCLC. We identified twenty epithelial LRs with significant prognostic implications and delineated three molecular NSCLC subtypes with distinct outcomes, pathological characteristics, biological pathways, and immune profiles. The LRrisk model was constructed using twelve differentially expressed ligand-receptor interaction-related genes (LRGs), with a focus on POPDC3 (popeye domain-containing protein 3), which was overexpressed in NSCLC cells. Functional assays revealed that POPDC3 knockdown reduced cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), while its overexpression promoted cancerous activities. In vivo, POPDC3 silencing hindered, and its overexpression accelerated the growth of NSCLC xenografts in nude mice. Additionally, high expression levels of POPDC3 in NSCLC tissues were associated with enhanced CD4 T cell infiltration and increased PD-1 expression within the TME. Moreover, ectopic POPDC3 overexpression in C57BL/6 J mouse Lewis lung carcinoma (LLC) xenografts enhanced CD4 T cell infiltration and PD-1 expression in the TME. This research establishes a robust epithelial LR-related signature, highlighting POPDC3 as a critical facilitator of NSCLC progression and a potential therapeutic target. - Source: PubMed
Publication date: 2025/02/19
Zhu Xiao-RenZhu Jia-QiGu Qian-HuiLiu NaLu Jing-JingLi Xiao-HongLiu Yuan-YuanZheng XianChen Min-BinJi Yong - Structural variants (SVs) such as deletions, duplications, and insertions are known to contribute to phenotypic variation but remain challenging to identify and genotype. A more complete, accessible, and assessable collection of SVs will assist efforts to study SV function in cattle and to incorporate SV genotyping into animal evaluation. - Source: PubMed
Publication date: 2024/09/30
Grant Jason RHerman Emily KBarlow Lael DMiglior FilippoSchenkel Flavio SBaes Christine FStothard Paul - Breast cancer is one of the most prominent types of cancers, in which therapeutic resistance is a major clinical concern. Specific subtypes, such as claudin-low and metaplastic breast carcinoma (MpBC), have been associated with high nongenetic plasticity, which can facilitate resistance. The similarities and differences between these orthogonal subtypes, identified by molecular and histopathological analyses, respectively, remain insufficiently characterized. Furthermore, adequate methods to identify high-plasticity tumors to better anticipate resistance are lacking. Here, we analyzed 11 triple-negative breast tumors, including 3 claudin-low and 4 MpBC, via high-resolution spatial transcriptomics. We combined pathological annotations and deconvolution approaches to precisely identify tumor spots, on which we performed signature enrichment, differential expression, and copy number analyses. We used The Cancer Genome Atlas and Cancer Cell Line Encyclopedia public databases for external validation of expression markers. By focusing our spatial transcriptomic analyses on tumor cells in MpBC samples, we bypassed the negative impact of stromal contamination and identified specific markers that are neither expressed in other breast cancer subtypes nor expressed in stromal cells. Three markers (BMPER, POPDC3, and SH3RF3) were validated in external expression databases encompassing bulk tumor material and stroma-free cell lines. We unveiled that existing bulk expression signatures of high-plasticity breast cancers are relevant in mesenchymal transdifferentiated compartments but can be hindered by abundant stromal cells in tumor samples, negatively impacting their clinical applicability. Spatial transcriptomic analyses constitute powerful tools to identify specific expression markers and could thus enhance diagnosis and clinical care of rare high-plasticity breast cancers. - Source: PubMed
Publication date: 2023/10/07
Coutant AngèleCockenpot VincentMuller LaurianeDegletagne CyrilPommier RoxaneTonon LaurieArdin MaudeMichallet Marie-CécileCaux ChristopheLaurent MarieMorel Anne-PierreSaintigny PierrePuisieux AlainOuzounova MariaMartinez Pierre