Ask about this productRelated genes to: CMTM2 antibody
- Gene:
- CMTM2 NIH gene
- Name:
- CKLF like MARVEL transmembrane domain containing 2
- Previous symbol:
- CKLFSF2
- Synonyms:
- MGC39436, FLJ25732
- Chromosome:
- 16q21
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-10
- Date modifiied:
- 2016-10-05
Related products to: CMTM2 antibody
Related articles to: CMTM2 antibody
- Myocardial infarction (MI) is a myocardial necrosis event caused by an unstable ischemic state that reduces life expectancy primarily through cardiac functional impairment and cardiomyocyte death. The present study aims to investigate the genetic mechanisms underlying MI by integrating expression quantitative trait loci (eQTLs) and Mendelian randomization (MR) analyses. - Source: PubMed
Publication date: 2026/03/11
He PeichunLv XiangwenFu ChuwenQin ZhenChen SiyuanZhao JinminXie Jian - To explore the role of the CMTM2 gene in regulating testicular spermatogenesis in the mouse model of experimental autoimmune orchitis (EAO). - Source: PubMed
Xu Jun-TaiMa Hong-BinWang De-KeTian Zhen-Fang - Esophageal carcinoma (ESCA) is one of the most common malignant diseases and contributes to the annual burden of death worldwide. A better understanding of the underlying molecular changes is urgently required to identify early diagnostic biomarkers and effective therapeutics. The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) is reported to be entangled in many human cancers. However, the role of CMTMs in ESCA remains unclear. - Source: PubMed
Publication date: 2025/04/03
Xue LiyingGou ShutingZhang YuYuan RuiruiDong ChangHao RongyaoAn NaZhang XianghongLi Jie - The CMTM family plays pivotal roles in various physiological and pathological processes, including those associated with the male reproductive system. Among them, CMTM2 exhibits specific expression in testicular tissue; however, its relationship with spermatogenesis, sperm function, and the underlying molecular mechanisms remains unclear. This study systematically investigated the localization of CMTM2 in human testis and sperm, as well as its correlation with spermatogenesis and sperm quality. The results revealed that CMTM2 expression was specifically localized in human testis, predominantly in germ cells, with significantly lower levels observed in sperm from patients with asthenozoospermia and teratozoospermia compared to normospermic individuals. Immunofluorescence analysis revealed that CMTM2 was predominantly localized in the middle piece of sperm, with significant reductions in infertile samples. Western blot analysis confirmed decreased CMTM2 levels in sperm from asthenozoospermia, oligozoospermia, and teratozoospermia patients, indicating a strong correlation between CMTM2 expression and sperm quality. Furthermore, CMTM2 expression positively correlated with sperm progressive motility, but not with sperm concentration, suggesting its potential role in regulating sperm motility in both normal and asthenozoospermia patients. The findings suggested a significant correlation between the CMTM2 expression and spermatogenesis as well as sperm quality, thereby providing valuable insights for further investigations into the molecular mechanisms involved. These results lay a foundational basis for exploring the potential roles of other members within the CMTM family in male reproduction. - Source: PubMed
Publication date: 2025/04/01
XueXia LiuBenJiao GongXueYing ZhangPeng ZhuFuJun Liu - Associations between ulcerative colitis (UC) and ankylosing spondylitis (AS) have been reported in multiple studies, but the common etiologies of UC and AS remain unknown. Thus, in the current study, we aimed to investigate the shared genes and relevant mechanisms in UC and AS. - Source: PubMed
Publication date: 2025/02/04
Li LinAn GuangqiLi FuzhenZhang DonghuiZhu XinyueLiang ChunyuZhao YuXie KunpengZhou PengyiZhu HaiyanJin XueminDu Liping