Ask about this productRelated genes to: SLC36A2 antibody
- Gene:
- SLC36A2 NIH gene
- Name:
- solute carrier family 36 member 2
- Previous symbol:
- -
- Synonyms:
- PAT2, tramdorin, TRAMD1
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-13
- Date modifiied:
- 2016-02-17
Related products to: SLC36A2 antibody
Related articles to: SLC36A2 antibody
- Amino acids play vital roles in protein synthesis, energy metabolism, and cellular function. Aminoacidurias are metabolic disorders characterized by excessive urinary excretion of amino acids resulting from defects in renal tubular reabsorption or amino acid metabolism. These disorders result from a combination of genetic mutations affecting transporter proteins and environmental factors that influence disease severity. This review aims to explore the molecular mechanisms by which genetic and environmental factors disrupt amino acid homeostasis. - Source: PubMed
Publication date: 2025/10/09
Ajayi Joseph AbayomiAnanias Evelyn NnashiruIssa-Lawal MuneerahGambari Abdulkadir MashoodAribatise Adetoun BunmiOjulari Lekan SheriffAlagbonsi Abdullateef Isiaka - Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown adipocytes also utilize other substrates, such as amino acids, for energy expenditure in various conditions. Here, we report the new physiological roles of proton-coupled amino acid transporters, SLC36A2 and SLC36A3, on global energy metabolism. The relative mRNA expression levels of both and were all highest in brown adipose tissue. We then generated global and knockout mice to investigate their functions in metabolism. Neither loss of nor affected the body weight and body composition of the mice. knockout mice exhibited increased oxygen consumption during the daytime. After cold treatment, inhibition of significantly decreased the mass of brown adipose tissue compared to wildtype mice, while it lowered the expression level of . Moreover, the serum lipid levels and liver mass were also decreased in knockout mice after cold treatment. On the contrary, knockout impaired glucose tolerance and up-regulated serum LDL-cholesterol concentration. Thus, SLC36A2 and SLC36A3 play central and different roles in the energy metabolism of the mice. - Source: PubMed
Publication date: 2023/08/11
Shu HuiZhang JieCheng DaweiZhao XiaoruiMa YueZhang ChiZhang YongJia ZhihaoLiu Zhiwei - Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral and maxillofacial region. Due to the special physiological and anatomical position of the oral cavity, the disease often has a significant impact on the chewing, swallowing, language, and breathing functions of patients. In recent years, with the development of medical molecular biology, molecular targeted therapy has received increasing clinical attention and has gradually become a new method for the treatment of malignant tumors. In this research, gold nanostars with a high photothermal effect combined with the searched targeted antibody were used for OSCC therapy. We use the data set in the public database and construct a gene co-expression module by weighted gene co-expression network analysis (WGCNA). It was found that the turquoise module and the midnight blue module had the greatest connection to tumorigenesis. Cytoscape software was used to analyze the important modules, and the top 10 genes of each module were selected; the survival analysis of the top 10 genes was carried out by gene expression profiling interactive analysis (GEPIA), which indicated that these genes (SERPINH1, MMP11, ADAM12, FADS3, SLC36A2, C1QTNF7, SCRG1, and APOBEC2) have statistical significance as key genes that are related to the tumorigenesis of OSCC. Then, the anti-SERPINH1 antibody targeted to SERPINH1 was chosen as the inhibitor and combined with gold nanostars for photothermal assisted targeted therapy. Thus, the searched key genes can be regarded as biomarkers and therapeutic targets for further precise diagnosis. - Source: PubMed
Publication date: 2022/05/22
Cai LinglingWang YanxingPeng XiangrongLi WenjingYuan YingTao XiaofengYao XinweiLv Ruichan - Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability. Amongst the multiple factors influencing brown adipocyte activity, autophagy is an important regulatory element of thermogenic capacity and activity. Nevertheless, a specific sensing mechanism of extracellular amino acid availability linking autophagy to nutrient availability in brown adipocytes is unknown. - Source: PubMed
Publication date: 2022/05/02
Wang JiefuOnogi YasuhiroKrueger MartinOeckl JosefKarlina RuthSingh InderjeetHauck Stefanie MFeederle ReginaLi YongguoUssar Siegfried - Isolated hyperglycinuria is a rare disorder that is associated with osteoporosis and renal calculi. We report findings in a middle-aged, black woman who presented for renal function evaluation with a history of transient hypobicarbonataemia associated with topiramate therapy. She displayed the full triad of high urinary glycine, early-onset osteopenia despite normal reproductive hormones, and renal calculus with high urinary oxalate, phosphate and uric acid. Parathyroid hormone and fibroblast growth factor 23 were both normal. Formal genetic testing did not reveal mutations in SLC6A20, SLC6A18, SLC6A19, SLC36A2, the known genes associated with glycinuria; however, black individuals are poorly represented in the genetic databases. It may well be that otherwise unidentified mutations may be present or that topiramate may result in a lingering proximal tubule defect even after cessation of the drug. - Source: PubMed
Publication date: 2022/03/02
Fargaly HithemMathew ShobiRossi Noreen F