Ask about this productRelated genes to: LRRC52 antibody
- Gene:
- LRRC52 NIH gene
- Name:
- leucine rich repeat containing 52
- Previous symbol:
- -
- Synonyms:
- FLJ25811
- Chromosome:
- 1q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-25
- Date modifiied:
- 2016-10-05
Related products to: LRRC52 antibody
Related articles to: LRRC52 antibody
- BK channels are expressed in mouse cochlear inner hair cells (IHCs) and exhibit Ca-independent activation at negative potentials. However, the mechanism underlying Ca-independent activation of the BK channels in mouse IHCs remains unknown. In this study, we found the BK channel expressed in IHCs contains both the stress-axis regulated exon 2 variant and an alternative splice of exon9 (alt9), which significantly shift the voltage dependence of the BK channels when coexpressed with LRRC52 in 0 [Ca]. Furthermore, we discovered that mechanical force also induces negative shifts in the voltage dependence of IHC-expressed BK channels. Thus, we propose that the additive effects of mechanical force, special isoforms, and LRRC52 coexpression on voltage dependence shifts may account for the Ca-independent activation of the BK channel in IHC. Additionally, we found that the IHCs-specific deletion of the BK channels causes hearing damage in mice. Our study suggests a mechanism for Ca-independent activation in IHCs and highlights the crucial role of the BK channel in auditory perception. - Source: PubMed
Publication date: 2024/11/07
Shen Zhong-ShanGan JunXu BingChen Ya-LinZhang Fei-FeiJi Jun-WeiChen Dan-HuaQiao YuehuaTang Qiong-YaoZhang Zhe - Sperm-specific potassium channel (KSper) comprised of pore-forming subunit SLO3 and auxiliary subunit LRRC52 is of importance for sperm fertility. The deficiency of KSper in both mice and humans resulted in severe impairments of sperm functions including sperm hyperactivity and acrosome reaction. Previous reports suggested that mouse KSper modulated sperm function possibly by affecting sperm intracellular pH (pH). However, the precise signaling mechanism of human KSper (hKSper) on the regulation of sperm functions was largely unclear. - Source: PubMed
Publication date: 2024/11/05
Ji NanxiWang XiaorongZeng XuhuiKang Hang - Long non-coding RNA (lncRNA), especially RNA associated with lymph node metastasis, plays an important role in the development of cancer. Identifying metastasis related lncRNAs and exploring their clinical significance can guide the treatment and prognosis of thyroid cancer patients. - Source: PubMed
Publication date: 2024/03/06
Liu RuijingLiu WenXue JingliJiang BeibeiWei YuQingYin YiqiangLi Peifeng - Completion of fertilization is orchestrated by various ion channels in sperm membrane. Hyperpolarization of membrane potential, an indispensable event during the capacitation process, is dominated by sperm potassium channel (KSper). In addition to sperm-specific SLO3, which forms the channel pore, the auxiliary subunit leucine-rich-repeat-containing protein 52 (LRRC52) is required to form mKSper to function under physiological conditions. However, in human sperm, although most evidence supports that hSLO3 is the pore-forming subunit, whether hLRRC52 contributes to hKSper conductance and modulates sperm function remains to be understood. Here, using an extracellular segment that is homologous between mice and humans as an antigen, we developed a polyclonal antibody designed as LID1 that specifically detected mLRRC52 and performed co-immunoprecipitation with mSLO3. Additionally, patch-clamp recordings of mouse sperm showed that, physiological activation of mKSper and sperm functions were dramatically attenuated after treatment with LID1, indicating that LID1 functionally disrupted the regulation of mLRRC52 on mKSper. Next, LID1 was used to investigate the significance of hLRRC52 for hKSper activation. As a result, hLRRC52 was expressed in human sperm and might be assembled with hSLO3. More importantly, LID1 inhibited hKSper currents and depolarized sperm membrane potential, supporting essential modulation of hLRRC52 in hKSper. Ca2+ signaling of human sperm was also compromised in the presence of LID1, which impaired sperm motility and acrosome reaction. Because LID1 specifically inhibited both mKSper and hKSper but not mCatSper or hCatSper, our results suggest that hLRRC52 functions as an important component of hKSper and regulates sperm physiological functions. - Source: PubMed
Zhang JialiZheng LipingChen YingLuo TaoZeng XuhuiKang Hang - Improved molecular testing for common somatic mutations and the identification of mRNA and microRNA expression classifiers are promising approaches for the diagnosis of thyroid nodules. However, there is a need to improve the diagnostic accuracy of such tests for identifying thyroid cancer. Recent findings have revealed a crucial role of long non-coding RNAs (lncRNAs) in gene modulation. Thus, we aimed to evaluate the diagnostic value of selected lncRNAs from The Atlas of Noncoding RNAs in Cancer (TANRIC) thyroid cancer dataset. - Source: PubMed
Publication date: 2022/09/05
Kim DahamYu JuyeonKim JiwonHwang Yoon-AKim Jin KyongKu Cheol RyongYoon Jung HyunKwak Jin YoungNam Kee-HyunLee Eun Jig