Ask about this productRelated genes to: ABCF3 antibody
- Gene:
- ABCF3 NIH gene
- Name:
- ATP binding cassette subfamily F member 3
- Previous symbol:
- -
- Synonyms:
- EST201864
- Chromosome:
- 3q27.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2015-11-13
Related products to: ABCF3 antibody
Related articles to: ABCF3 antibody
- The small brown planthopper (SBPH), Laodelphax striatellus, is a highly destructive pest, which seriously threatens the production of high-quality rice. Triflumezopyrim, a novel insecticide widely used against planthoppers, which will inevitably produce resistance in the process of long-term use. ATP-binding cassette (ABC) transporters play a significant role in phase III detoxification process and may contribute substantially to insecticide resistance. In this study, 41 ABC transporters were identified in the L. striatellus genome. Synergism studies revealed that verapamil significantly increased triflumezopyrim toxicity against L. striatellus. Five ABC transporters, ABCC12, ABCF3, ABCG11, ABCG12 and ABCH1, were up-regulated over two-fold following triflumezopyrim exposure. Furthermore, RNAi-mediated suppression of ABCG11 or ABCH1 expression significantly increased susceptibility to triflumezopyrim. Additionally, injection of agomir-PC-5p-3991_515 significantly decreased the expression of ABCG11 and ABCH1, and enhanced the susceptibility of L. striatellus to triflumezopyrim. Dual luciferase reporter assay confirmed the interaction between PC-5p-3991_515 and ABCG11 or ABCH1. These results demonstrate that PC-5p-3991_515 modulates triflumezopyrim tolerance in L. striatellus by targeting ABCG11 and ABCH1. This study enhances the understanding of transcriptional regulation of triflumezopyrim tolerance mediated by miRNA-ABC transporter and has guiding significance for the management of L. striatellus and other pests. - Source: PubMed
Publication date: 2025/10/24
Yang YuanxueDuan AilingMeng DiWang AiyuZhao MingZhang Jianhua - A notable signalling mechanism employed by mammalian innate immune signalling pathways uses nucleotide-based second messengers such as 2'3'-cGAMP and 2'-5'-oligoadenylates (OAs), which bind and activate STING and RNase L, respectively. Interestingly, the involvement of nucleotide second messengers to activate antiviral responses is evolutionarily conserved, as evidenced by the identification of an antiviral cGAMP-dependent pathway in . Using a mass spectrometry approach, we identified several members of the ABCF family in human, mouse and cell lysates as 2'-5' OA-binding proteins, suggesting an evolutionarily conserved function. Biochemical characterization of these interactions demonstrates high-affinity binding of 2'-5' OA to ABCF1, dependent on phosphorylated 2'-5' OA and an intact Walker A/B motif of the ABC cassette of ABCF1. As further support for species-specific interactions with 2'-5' OA, we additionally identified that the metabolic enzyme Decr1 from mouse, but not human or cells, forms a high-affinity complex with 2'-5' OA. A 1.4 Å co-crystal structure of the mouse Decr1-2'-5' OA complex explains high-affinity recognition of 2'-5' OA and the mechanism of species specificity. Despite clear evidence of physical interactions, we could not identify profound antiviral functions of ABCF1, ABCF3 or Decr1 or 2'-5' OA-dependent regulation of cellular translation rates, as suggested by the engagement of ABCF proteins. Thus, although the biological consequences of the here identified interactions need to be further studied, our data suggest that 2'-5' OA can serve as a signalling hub to distribute a signal to different recipient proteins. - Source: PubMed
Govande Apurva ABabnis Aleksandra WUrban ChristianHabjan MatthiasHartmann RuneKranzusch Philip JPichlmair Andreas - The identification and selection of genetically superior animals for residual feed intake (RFI) could enhance productivity and minimize environmental impacts. The aim of this study was to use RNA-seq data to identify the differentially expressed genes (DEGs), known non-coding RNAs (ncRNAs), specific biomarkers and enriched biological processes associated with RFI of the liver in Nellore cattle in two genetic groups. In genetic group 1 (G1), 24 extreme RFI animals (12 low RFI (LRFI) versus 12 high RFI (HRFI)) were selected from a population of 60 Nellore bulls. The RNA-seq of the samples from their liver tissues was performed using an Illumina HiSeq 2000. In genetic group 2 (G2), 20 samples of liver tissue of Nellore bulls divergent for RFI (LRFI, = 10 versus HRFI, = 10) were selected from 83 animals. The raw data of the G2 were chosen from the ENA repository. A total of 1811 DEGs were found for the G1 and 2054 for the G2 (-value ≤ 0.05). We detected 88 common genes in both genetic groups, of which 33 were involved in the immune response and in blocking oxidative stress. In addition, seven (, , , , , , and ) possible gene biomarkers were identified through a receiver operating characteristic analysis (ROC) considering an AUC > 0.70. The gene was overexpressed in the LRFI group. This gene regulates the lipid metabolism protein turnover and inhibits cell death. We also found non-coding RNAs in both groups. MIR25 was up-regulated and SNORD16 was down-regulated in the LRFI for G1. For G2, up-regulated RNase_MRP and SCARNA10 were found. We highlight MIR25 as being able to act by blocking cytotoxicity and oxidative stress and RMRP as a blocker of mitochondrial damage. The biological pathways associated with RFI of the liver in Nellore cattle in the two genetic groups were for energy metabolism, protein turnover, redox homeostasis and the immune response. The common transcripts, biomarkers and metabolic pathways found in the two genetic groups make this unprecedented work even more relevant, since the results are valid for different herds raised in different ways. The results reinforce the biological importance of these known processes but also reveal new insights into the complexity of the liver tissue transcriptome of Nellore cattle. - Source: PubMed
Publication date: 2023/01/20
Serna-García MartaFonseca Larissa Fernanda SimielliPanadero Romero Joaquin JavierCarretero Asuncion JulianDos Santos Silva Danielly BeraldoSalatta Bruna MariaFrezarim Gabriela BonfáMercadante Maria Eugênia ZerlottiBonilha Sarah Figueiredo MartinsFerro Jesus AparecidoDe Albuquerque Lucia Galvão - Tambaqui, Colossoma macropomum, is the most important native fish species farmed in South America, particularly in Brazil, where its production is limited in the southern and southeastern regions due to disease outbreaks caused by the parasite Ichthyophthirius multifiliis. Therefore, genome level analysis to understand the genetic architecture of the host resistance against I. multifiliis is fundamental to improve this trait in tambaqui. The objective of the present study was to map QTL (quantitative trait loci) associated with resistance to I. multifiliis in tambaqui by GWAS (genome-wide association study). - Source: PubMed
Publication date: 2022/11/11
Lira Lieschen V GMastrochirico-Filho Vito AMendes Natalia JAriede Raquel BYáñez José MHashimoto Diogo T - Problems arising during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality control events. However, the global cellular response to ribosome collisions has not been explored. Here, we uncover a function for ribosome collisions in signal transduction. Using translation elongation inhibitors and general cellular stress conditions, including amino acid starvation and UV irradiation, we show that ribosome collisions activate the stress-activated protein kinase (SAPK) and GCN2-mediated stress response pathways. We show that the MAPKKK ZAK functions as the sentinel for ribosome collisions and is required for immediate early activation of both SAPK (p38/JNK) and GCN2 signaling pathways. Selective ribosome profiling and biochemistry demonstrate that although ZAK generally associates with elongating ribosomes on polysomal mRNAs, it specifically auto-phosphorylates on the minimal unit of colliding ribosomes, the disome. Together, these results provide molecular insights into how perturbation of translational homeostasis regulates cell fate. - Source: PubMed
Publication date: 2020/06/30
Wu Colin Chih-ChienPeterson AmyZinshteyn BorisRegot SergiGreen Rachel