Ask about this productRelated genes to: SLC43A2 antibody
- Gene:
- SLC43A2 NIH gene
- Name:
- solute carrier family 43 member 2
- Previous symbol:
- -
- Synonyms:
- MGC34680
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-17
- Date modifiied:
- 2016-02-17
Related products to: SLC43A2 antibody
Related articles to: SLC43A2 antibody
- Stillbirth (SB) in dairy cattle is both an animal welfare and an economic issue. The reasons for SB and how traits like gestation length (GL) influence it are part of ongoing research. Utilizing imputed high-density (HD) and whole-genome sequencing (WGS) genotypes from 34,497 German Holstein cows, this study aimed to identify local genetic correlation in trait associated genomic regions for SB and GL. For this, regional heritability mapping (RHM) was conducted, alongside analyses of global and local genetic correlation. In the downstream analysis, regions showing significant local genetic correlations within significant RHM windows were searched for candidate genes. RHM of direct effects on GL resulted in 2 significant regions on BTA18 and 19 in first (GL_d1) and second parity (GL_d2). One region on BTA9 was significant for the maternal effect on SB. Significant global genetic correlations were confined to a low negative correlation of -0.17 (SE = 0.04) between SB direct (SBd) and GL_d1. Their local genetic correlations were negative on BTA18 and positive on BTA19, with ZNF415 and SLC43A2 as candidate genes. The gene ontology enrichment analysis for SBd and GL_d1 identified biologically relevant pathways, with the largest cluster related to the transport of organic acids and amino acids. Overall, the study achieved insights into the complex genetic architecture of SB and its interaction with GL. Candidate genes of still unknown function should be considered by future research to further strengthen the understanding of trait interactions. - Source: PubMed
Publication date: 2026/04/09
Zölch MaximilianHaas Valentin PKeßler FranziskaKrižanac Ana-MarijaReimer ChristianSchmidtmann ChristinAlkhoder HatemTetens JensBennewitz Jörn - Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder worldwide. A prodromal stage, often manifested as Mild Cognitive Impairment (MCI), can precede dementia onset. Metabolomics provides a powerful approach to detect metabolic alterations capturing combined genetic, epigenetic, dietary, gut microbiota, and environmental influences on AD pathogenesis and progression from MCI to AD. In this study, we analysed plasma, urine, and saliva metabolomes of 94 ethnically diverse Brazilian individuals (30 AD, 16 MCI and 48 healthy controls), all comorbidity-free, using Nuclear Magnetic Resonance (NMR)-based metabolomics. Cross-sectional analysis employed multivariate modelling (PLS-DA) and univariate Mann-Whitney U tests. We identified distinct group-specific metabolic signatures involving amino acids (phenylalanine, glutamine, asparagine, valine, alanine), energy-related metabolites (pyruvate, citrate, glucose), compounds linked to lipid/redox pathways (acetate, glutamate, aspartate), epigenetic regulation (betaine), neuroinflammation, immune fitness, and gut microbiome-influenced metabolites (scyllo-inositol). Valine increased progressively (controls < MCI < AD), while alanine showed a biphasic pattern (reduced in MCI, elevated in AD). These consistent, biofluid-spanning alterations highlight their potential as minimally invasive biomarkers for diagnosis and monitoring. Integration of metabolite data with AD-associated genes from genome-wide association studies (GWAS) revealed six genes (CYCS, NFAT5, GRIN2B, SLC43A2, MAPT, and SLC38A1) common to all biofluids, reinforcing convergent systemic pathways. Collectively, these findings underscore the importance of integrating metabolomics with genetic networks to enhance understanding of AD pathophysiology, identify potential therapeutic targets, and guide future clinical validation and precision medicine strategies for dementia in ethnically mixed populations. - Source: PubMed
Publication date: 2026/01/12
Cadaxo André SimõesCotrin Juliana CordovilValente Ana PaulaLopes Flávia GomesVeras Renato PeixotoTorres Daniel SimplícioMolina da Costa Raquel QuimasDos Santos Junior Gilson CostaSantos-Rebouças Cíntia Barros - Lung cancer incidence among never-smoking women in Xuanwei, China, is among the highest worldwide and is primarily attributed to household air pollution (HAP) from smoky (bituminous) coal combustion, with early-life exposure identified as playing a critical role. We conducted epigenome-wide DNA methylation (DNAm) analyses of HAP exposure and its polycyclic aromatic hydrocarbon (PAH) constituents across exposure windows. Leukocyte DNAm was measured in 106 never-smoking women, including 23 individuals with repeated measurements. Cooking fuel use and stove type was obtained through questionnaire, and comprehensive personal and environmental air monitoring was conducted. Validated exposure models estimated 43 HAP constituents, predominantly PAHs, across childhood, current, and cumulative exposure windows, and PAH clusters were derived via hierarchical clustering. Generalized estimating equations were used to identify CpG sites associated with HAP exposure and PAH clusters, including 5-methylchrysene, a methylated PAH previously linked to lung cancer. We identified several differentially methylated CpG sites, predominantly hypomethylated with higher HAP exposure. Although some DNAm signatures overlapped with those observed in smoking, the majority were distinct. Notably, higher current exposure to 5-methylchrysene was significantly associated with hypomethylation at cg05575921 (AHRR; p = 2.05x10), an established smoking marker. Life-course analyses indicated lasting DNAm variations with both childhood and cumulative PAH exposures at loci such as SLC43A2. Within the PAH clusters, 5-methylchrysene was a key contributor to DNAm variations. Top CpG sites were linked to immune regulation, G-protein coupled signaling, and molecular mechanisms of cancer and other disease pathways. These findings provide novel insight into HAP-induced DNAm changes and their potential health implications. - Source: PubMed
Publication date: 2026/01/05
Rahman Mohammad LPortengen LützenBlechter BatelBreeze Charles EWong Jason Y YHu WeiDownward George SZhang YongliangCardenas AndresNing BouLi JihuaYang KaiyunHosgood H DeanSilverman Debra TRothman NathanielHuang YunchaoVermeulen RoelLan Qing - Tumor-associated macrophages (TAMs) comprise heterogeneous subtypes with context-dependent functions in tumor immunity. Although macrophage senescence influences diverse diseases, its role in neuroblastoma (NB) progression remains undefined. - Source: PubMed
Publication date: 2026/01/06
Qiu SitongHu YouyangWang YimingXian HuaYin Qiyou - - Source: PubMed
Bian YingjieLi WeiKremer Daniel MSajjakulnukit PeterLi ShashaCrespo JoelNwosu Zeribe CZhang LiCzerwonka ArkadiuszPawłowska AnnaXia HoujunLi JingLiao PengYu JialiVatan LindaSzeliga WojciechWei ShuangGrove SaraLiu J RebeccaMcLean KarenCieslik MarcinChinnaiyan Arul MZgodziński WitoldWallner GrzegorzWertel IwonaOkła KarolinaKryczek IlonaLyssiotis Costas AZou Weiping