Ask about this productRelated genes to: PI16 antibody
- Gene:
- PI16 NIH gene
- Name:
- peptidase inhibitor 16
- Previous symbol:
- -
- Synonyms:
- MGC45378, dJ90K10.5, MSMBBP, CD364
- Chromosome:
- 6p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-29
- Date modifiied:
- 2016-10-05
Related products to: PI16 antibody
Related articles to: PI16 antibody
- The tumor microenvironment (TME) is a major determinant of tumor response to different therapies, especially immunotherapy. Tumors with high CD8 T-cell infiltration that respond well to immunotherapy are referred to as "hot" tumors, whereas "cold" tumors, with an immunosuppressive microenvironment, respond less effectively to this therapy. Endoglin (CD105) plays a critical role in angiogenesis, and its overexpression has been associated with a poorer prognosis in several types of cancer. This study aims to investigate whether high endoglin levels are associated with a cold microenvironment in tumors. Transgenic mice ubiquitously overexpressing human endoglin (ENG) and wild-type C57BL/6J mice (WT) were used to analyze the TME in a Lewis Lung Carcinoma (LLC) subcutaneous xenograft model and in a lung cancer model. Tumors developed in ENG mice exhibited increased hypoxia, reduced CD8 T-cell infiltration and an increased presence of immunosuppressive cells, such as M2 TAMs and Treg, compared to WT tumors. Thus, these tumors can be categorized as cold tumors. In addition, the analysis of the TME and endoglin expression in human lung adenocarcinoma samples showed that cold tumors have higher endoglin levels than hot tumors. These findings suggest that a hypoxic and immunosuppressive microenvironment may contribute to the poorer prognosis of tumors with high levels of this protein. This study highlights the potential of endoglin as a marker to predict the response to immunotherapy and to guide personalized treatment strategies in cancer patients. - Source: PubMed
Publication date: 2026/06/12
Ollauri-Ibáñez ClaudiaAyuso-Íñigo BlancaSolano-Sc InésDíez PaulaPerez-Andres MartínMuñoz-Félix José MRodríguez-Barbero AliciaPericacho Miguel - Hepatitis E virus genotype 3 (HEV-3) is a major cause of acute hepatitis in Europe. However, the clinical burden of symptomatic infection in routine practice and the relative contribution of host and viral factors to disease severity remain incompletely defined. We aimed to characterise the clinical burden, molecular epidemiology and determinants of adverse outcomes in patients with symptomatic HEV-3 infection. - Source: PubMed
Publication date: 2026/06/12
Casares-Jimenez MaríaFerreira-Tata ClaudiaViciana IsabelFreyre-Carrillo CarolinaLopez-Lopez PedroPerez Ana BelenBecerril-Carral BertaFuentes AnaMacías JuanRios-Muñoz Luciade Luna Francisco Franco-AlvarezCabezas-Fernandez María TeresaCorona-Mata DianaRivero-Juarez AntonioRivero Antonio - The use of high-resolution data in the intensive care unit (ICU) environment allows for more detailed research into invasive mechanical ventilation (IMV) management and patient-ventilator interactions and their relationship with clinical outcome. The Real-time Agnostic Monitoring for Intensive Care (RAMIC-I) database is a single-center, de-identified dataset containing clinical and physiological data collected from 155 critically ill adults admitted to the ICU of Hospital Universitari Parc Taulí (Sabadell, Spain), between 2015 and 2019. RAMIC-I includes 13,433 hours of mechanical ventilation recorded during the first eight days of IMV, enriched with demographic information, bedside clinical variables (including clinical management variables, administered treatments, and clinical scores), vital signs, and mortality outcomes. Derived variables from respiratory waveforms, including patient-ventilator asynchronies, were aggregated into 10-minute resolution intervals to enable a comprehensive exploration of respiratory physiology during IMV. The dataset is structured according to FAIR data principles and is accessible through a federated repository based on the open-source infrastructure. This detailed resource supports research into predictive modeling, IMV optimization, and the study of patient-ventilator interactions in critical care settings. - Source: PubMed
Publication date: 2026/06/10
Santos-Pulpón VerónicaSuñol FrancescLópez-Aguilar Josefinade Haro CandelariaFernández-Gonzalo SolGomà GemmaSantos Emilio DiazHuhle RobertWittenstein JakobBlanch LluísSarlabous Leonardo - The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal joints are spared, providing a model to investigate the predilection of inflammation to distinct sites. Here we combine single-cell RNA sequencing, imaging and X-ray tomography to examine cellular composition, spatial organization and structure of finger joints during fetal development. PIP joints had a larger synovial volume and were enriched for PI16 'universal' fibroblasts. These cells were located in perivascular regions and at developing tendon-ligament interfaces. PI16 fibroblasts exhibited both a shared inflammatory and cell-type-specific response to cytokine stimulation, suggesting that the combination of their spatial location and transcriptional responses promote inflammation. We suggest that differences in the stoichiometry of mesenchymal cells established in utero, including the key role of PI16 fibroblasts, is a general principle that drives inflammation susceptibility across tissues. - Source: PubMed
Publication date: 2026/06/08
Davidson SarahSimone DavideJansen KathrinCowan MaxMachado CaioReekie IanBhalla AnanyaBorst RowiePrada Medina CesarBull JoshuaWong Zhi YiHill SarahGarvilles MiconPledger SamNisa Patricia ReisSchwingen Nora RebeccaWindell DylanAttar MoustafaDisney CatherineBodey Andrew JParmenter AlissaByrne HelenAhmed SharifMarathe ShashidharaLee Peter DMahony ChrisCroft Adam PSansom StephenColes Mark CBuckley Christopher D - Elite boxing induces rapid metabolic changes that are not fully captured by conventional physiological measurements. A standardized untargeted serum metabolomics workflow based on liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS) was applied to samples collected before sparring, immediately after sparring, and 24 h after sparring in seven elite male boxers. The workflow included standardized sample collection, pooled quality-control monitoring, metabolite profiling, multivariate statistical analysis, and pathway interpretation. Acute sparring was associated with changes in metabolites related to glycolysis and gluconeogenesis, whereas the 24-h timepoint was associated with sulfur metabolism. Phosphatidylinositol PI(16:0/18:2(9Z,12Z)) showed strong discrimination of the immediate post-sparring state, and thiosulfate was associated with the 24-h recovery state. These findings support the use of this workflow for reproducible profiling of exercise-related metabolic changes in this cohort of seven elite male boxers. The protocol is intended for controlled small-cohort studies of acute exercise and short-term recovery and emphasizes reproducible sample handling, pooled quality-control monitoring, and interpretable downstream analysis. - Source: PubMed
Publication date: 2026/05/22
Sun PengZhang DongChen QinyiHe MengyangLi Biao