Ask about this productRelated genes to: NRG1 antibody
- Gene:
- NRG1 NIH gene
- Name:
- neuregulin 1
- Previous symbol:
- HGL, NRG1-IT2
- Synonyms:
- HRG, NDF, GGF
- Chromosome:
- 8p12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-19
- Date modifiied:
- 2015-01-28
Related products to: NRG1 antibody
Related articles to: NRG1 antibody
- Fungal infections are increasingly threatening public health due to the onset of multidrug-resistant fungal strains. Accordingly, the incidence of chemoresistant strains has steadily increased, along with associated mortality, thus highlighting the need for effective antifungal agents for the treatment of both localized and systemic infections. Post-transcriptional modifications are key regulators of fungal virulence, modulating the production of virulence factors, yeast-to-hyphae transition, biofilm formation, and chemoresistance phenomena, whereas fungal histone deacetylases are key regulators of these processes. Herein, we report a potent and selective histone deacetylase 6 inhibitor (named F2F-202, ) showing synergistic activity in combination with the azole antifungal voriconazole (VRC) through the modulation of fungal histone deacetylase Hda1. Compound showed growth inhibition against the azole-resistant ATCC 10231 strain in combination with VRC, combined with a significant reduction of yeast-to-hyphae morphological transition. Moreover, the synergistic combination /VRC affected the expression of key genes regulated by Hda1 activity and involved in morphogenesis, namely, , , and . Additionally, in combination with VRC was able to counteract the VRC-induced upregulation of , a gene involved in azole resistance. Finally, our data suggest that the synergistic combination downregulates gene expression at an early point and impairs the antioxidant response. This study offers cues for the development of therapeutic options targeting resistant fungal infections and potentially overcoming the limitations associated with antifungal drugs currently in clinical use. - Source: PubMed
Publication date: 2026/05/22
Barone SimonaMateu BaptistePiccolo MarialuisaGuadagni AnnaIrace CarloLembo FrancescaSumma VincenzoBuommino ElisabettaBrindisi Margherita - Wilms tumor presents a heterogeneous tumor microenvironment. This study aimed to characterize the tumor microenvironment and identify prognostic genes to improve therapeutic strategies. - Source: PubMed
Publication date: 2026/05/20
Gao ZhiqiangLin JieTang HuafeiLi AoLi RuiXu AoHu RuiXu ShuaiZhang MaolinYang WenmingHuang HaijingZhang ZhengLiu Feng - Sickle cell disease (SCD) is characterized by chronic hemolysis, inflammation, and progressive kidney injury which leads to renal failure and increased mortality rates with limited therapeutic options available. Neuregulin-1 (NRG-1) is a cytoprotective growth factor with anti-inflammatory and antioxidant properties and an established clinical safety profile in humans. Using Townes humanized sickle cell (HbSS) mice, we investigated whether NRG-1 mitigates kidney injury by reducing hemolytic and inflammatory mediators and enhancing renal cytoprotective and repair factors. NRG-1 treatment reduced plasma heme, lactate dehydrogenase, and pro-inflammatory cytokines levels, while increasing the proportion of circulating fetal hemoglobin-containing red blood cells (F-cells). Treatment mitigated urinary cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) elevations and improved renal histopathology, including reduced iron deposition, glomerular congestion, and sclerosis. NRG-1 also enhanced heme oxygenase-1 (HO-1) expression in HbSS kidneys and increased urinary renal repair biomarkers clusterin and epidermal growth factor (EGF). Collectively, these findings provide new mechanistic insight supporting further exploration of NRG-1 as a therapeutic agent for mitigating kidney injury in SCD. - Source: PubMed
Agbozo William KSolomon WesleyErskine Isaac JoeLekpor Cecilia EBabayewa OguljahanBashi AlaijahHarbuzariu AdrianaAsberry AquaAdel DrissAdjei SamuelPaemka LilyOfori-Acquah Solomon FStiles Jonathan K - Ineffective erythropoiesis is a hallmark of thalassemia syndromes. Growth differentiation factors, such as GDF15, play a crucial yet not fully understood role. - Source: PubMed
Piolatto AndreaTesio NicolòTeti MartinaKargutkar Neha SGaglioti Carmen MVoi VincenzoMandrile GiorgiaLongo FilomenaPiga Antonio GFerrero Giovanni B - Lung adenocarcinoma remains the most common subtype of non-small cell lung cancer (NSCLC), yet molecular epidemiology and real-world outcomes in Caribbean populations are poorly documented. - Source: PubMed
Publication date: 2026/05/04
Marlin RégineColomba EmelinePennont SabrinaZouzou AdelMoranton MarlyneBoukadoum NassimRandriamiarisoa HeriniainaRakotonarivo Jean-MarcBougas StefanosFard KarimMasson SoizicDramé MoustaphaJougon JacquesAldea MihaelaAgossou Moustapha