Ask about this productRelated genes to: PDGFD antibody
- Gene:
- PDGFD NIH gene
- Name:
- platelet derived growth factor D
- Previous symbol:
- -
- Synonyms:
- SCDGF-B, MSTP036, IEGF
- Chromosome:
- 11q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-22
- Date modifiied:
- 2015-08-25
Related products to: PDGFD antibody
Related articles to: PDGFD antibody
- The role of platelet-derived growth factor D () in mesenchymal cells is well-established, but its specific function in skeletal muscle generation remains unknown. This study reveals for the first time PDGFD's dual regulatory role in myogenesis: it acts both as a "guardian" maintaining the myoblast pool and as an "initiator" driving myogenic differentiation. Through single-cell RNA sequencing analysis of skeletal muscle from , we identified as a common candidate gene for both muscle and fat development. In the C2C12 cell model, knockdown significantly inhibited cell proliferation and promoted apoptosis, while overexpression enhanced viability and inhibited apoptosis, indicating its critical role in maintaining myoprogenic precursor cell homeostasis. Further studies revealed that interference downregulated key myogenic differentiation markers and , inhibiting differentiation. Its expression peaked during mid-differentiation (D5), suggesting temporal regulation of differentiation. Interestingly, although primarily acts through the PI3K/Akt pathway downstream of , knockdown did not show significant synergistic effects with PI3K/Akt pathway activation in inhibiting differentiation. This suggests may specifically regulate myogenic differentiation via an independent or parallel signaling axis. This study not only expands the known functions of in muscle biology but also provides new insights into the mechanisms by which growth factors coordinate cell fate decisions. - Source: PubMed
Publication date: 2026/03/18
Cao HongzhenWang JingWang YunzhouHuang JingsenChen WeiTang HuiChen JunfengXing BaosongZeng Yongqing - Understanding the genetic basis of adaptation to extreme environments is crucial in evolutionary biology. Gannan Tibetan sheep, which thrive in high altitudes with thin air and cold climates, demonstrate remarkable resilience. However, the genetic basis of their adaptations remains poorly understood. In this study, we conducted whole-genome resequencing of three indigenous Tibetan sheep breeds, including Ganjia ( = 12), Oula ( = 12), Kecai ( = 12), from the Gannan Tibetan Autonomous Prefecture (average altitude of 3,500 m) in China. By integrating our data with previously published genomic data of sheep from northern China (Altitude below 1,500 m), we examined the genetic population structure, ancestry components, and signatures of positive selection. - Source: PubMed
Publication date: 2026/03/27
Lv ChenxiaoChen LiliZou PanChen YanMa Yi - Pulmonary arterial hypertension (PAH) is a severe disease characterized by elevated pulmonary artery pressure, leading to heart failure and premature death if untreated. Genetic factors significantly contribute to PAH, and several genes have been linked to its development. According to the ClinGen PH-GCEP group, 12 genes have definitive evidence of association with PAH, three have moderate evidence, six have limited evidence, and five remain disputed due to insufficient genetic data. The aim of this study was to analyze variants in genes without definitive evidence in a cohort of 1480 individuals (954 PAH patients and 526 relatives) by next-generation sequencing (NGS). Variants were prioritized through a custom pipeline developed in-house and classification was performed according to ACMG guidelines. A total of 32 different variants were identified in 42 individuals (32 patients and 10 relatives, five of whom developed the disease): Two pathogenic or likely pathogenic variants in ABCC8 and 30 variants of unknown significance (VUS) in 10 genes (ABCC8, AQP1, BMPR1A, BMPR1B, BMP10, FBLN2, NOTCH3, SMAD1, SMAD4 and TET2). On the opposite, no candidate variants were detected in GGCX, KLF2, KLK1 or PDGFD genes. These findings provide further genetic evidence supporting the association of ABCC8 and related genes with PAH, while no candidate variants were detected in GGCX, KLF2, KLK1, or PDGFD. Further research is needed to confirm the functional impact of these variants. - Source: PubMed
Publication date: 2026/03/25
Miranda-Alcaraz LucíaMora-Gómez MónicaGallego-Zazo NataliaCruz-Utrilla AlejandroDel Cerro Marín María JesúsOchoa Parra NuriaMartín de Miguel IreneGutiérrez Ortiz EvaJiménez-Estrada Juan AndrésParra AlejandroCazalla MarioRamos SergioRodríguez-Canó ManuelSilván CristinaVásquez-Amell ValeriaArias PedroNevado Juliánde Jesús Pérez VinicioLapunzina PabloEscribano-Subías PilarTenorio-Castano Jair - Circulating platelet-derived growth factors (PDGFs) participate in the initiation and progression of cardiovascular diseases, yet their regulatory mechanisms remain poorly understood. This study aimed to investigate the influence of air pollution on PDGFs mRNA expression in platelets and its association with acute myocardial infarction (AMI) and major adverse cardiovascular events (MACEs). We included 153 AMI patients at admission to assess the relationship between pollutant levels and platelet PDGFs mRNA expression, and followed up 142 AMI patients after discharge to evaluate the prognostic value of PDGFs mRNA expression for MACEs. Results showed that PM was non-linearly associated with the mRNA expression levels of PDGFC and PDGFD, while SO was non-linearly associated with the mRNA expression level of PDGFA (P < 0.05). Compared to controls, AMI patients at admission had an elevated PDGFD mRNA expression with a 4.705-fold increase (P < 0.05). Furthermore, PDGFs mRNA level exhibited a non-linear relationship with AMI occurrence (P < 0.05). Higher PDGFA mRNA expression (Q4 vs. Q1) was associated with a reduced risk of MACEs. Similarly, medium to high expression levels of PDGFC mRNA (Q2-Q4 vs Q1) had a lower risk of MACEs with adjusted hazard ratio of 0.366 (95% CI: 0.155-0.861). These findings indicate that exposure to air pollutants is correlated with altered PDGFs mRNA expression in platelets and that such expression is significantly associated with both AMI and subsequent MACEs. The study highlights the potential of PDGFs mRNA in platelets as a biomarker for assessing individual susceptibility to air pollution-related cardiovascular events. - Source: PubMed
Publication date: 2026/03/16
Xie JichaoXie HankunXu LiangLiu FangyuanZhuang QianZhao XianghaiSun JunxiangWei PengfeiYin YunjieChen YanchunWang FeifanHan XuLi WenWu JiahuiZhou YuanHuan ChangshengYang SongShen Chong - - Source: PubMed
Publication date: 2026/03/18
Manzoor RabbiaGull IramAhmed AbrarHussain Tuba GhulamHussain UbaidaAslam Muhammad Shahbaz