Ask about this productRelated genes to: PNOC antibody
- Gene:
- PNOC NIH gene
- Name:
- prepronociceptin
- Previous symbol:
- -
- Synonyms:
- PPNOC, N/OFQ, NOP
- Chromosome:
- 8p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-28
- Date modifiied:
- 2016-10-05
Related products to: PNOC antibody
Related articles to: PNOC antibody
- : Mid-regional pro-adrenomedullin (MR-proADM) is a biomarker of endothelial dysfunction in sepsis. Its relationship with real-time microcirculatory alterations in critically ill patients remains insufficiently characterised. : In a prospective cohort of 59 ICU patients with sepsis, serial sublingual microcirculation assessments were performed using sidestream dark field (SDF) imaging. Serum MR-proADM concentrations were measured with BRAHMS Kryptor assays. Automated software quantified microvascular structure and flow. Associations with disease severity and outcomes were evaluated using correlation, regression, and receiver operating characteristic (ROC) analyses (ClinicalTrials.gov Identifier: NCT05357339). : Higher MR-proADM concentrations at ICU admission were modestly associated with impaired microvascular perfusion (perfused number of crossings [PNOC]: ρ = -0.32; perfused De Backer density [PDBD]: ρ = -0.32; consensus proportion of perfused vessels [CPPV]: ρ = -0.26; all < 0.05). Rising MR-proADM levels over time were strongly associated with worsening perfusion (ΔPDBD: ρ = 0.52; ΔPNOC: ρ = 0.54). MR-proADM correlated with SOFA and APACHE II scores and predicted the need for renal replacement therapy (AUC = 0.799, = 0.041), but not ICU length of stay or hospital mortality. : MR-proADM correlates with in vivo microcirculatory dysfunction in sepsis. Its dynamic association with microvascular impairment supports its potential role as a translational biomarker for monitoring endothelial and microcirculatory failure in critically ill patients. - Source: PubMed
Publication date: 2026/03/02
Cusack RachaelGarduno AlexisCumpf SanjaReyes-Morales PramilaLeone MarcFernández Alfonso BlancoRodriguez AlejandroMartin-Loeches Ignacio - An unhealthy diet disrupts feeding behavior and the gut microbiota, but whether early-life dietary effects persist, or can be restored later in life, remains unclear. We investigated whether microbiota-targeted interventions (FOS + GOS or Bifidobacterium longum APC1472) could restore early-life high-fat/high-sugar (HFHS) diet-induced feeding alterations in adult female and male mice. HFHS exposure exclusively in early-life induced persistent, sex-specific feeding alterations in adult mice, despite normalized body weight. Early-life HFHS diet reduced hypothalamic cells expressing feeding-related markers (POMC, GHSR, PNOC, NOD2) in adult mice. Females were more vulnerable, with reduced LEPR cells and disrupted arginine/tryptophan metabolism, while males showed impaired peptidoglycan sensing and steroid metabolism. We show that microbiota interventions restore these effects via distinct mechanisms. FOS + GOS induced extensive microbiome compositional shifts and sex-specific restoration of gut-brain pathways, while B. longum APC1472 induced greater behavioral restoration with minimal microbiome compositional changes. These findings highlight sex-specific vulnerabilities and mechanism-dependent therapeutic potential of microbiota-based interventions after exposure to early-life unhealthy diets. - Source: PubMed
Publication date: 2026/02/24
Cuesta-Marti CristinaPonce-España EduardoUhlig FriederikeStoltenborg IrisWasiewska Luiza AKareem LamiahHedayatpour DaraOlavarría-Ramírez LoretoRosell-Cardona CristinaBastiaanssen Thomaz F STofani Gabriel S SValderrama BenjaminVlckova KlaraDickson Suzanne LLavelle AonghusStanton CatherineRoss R PaulCryan John FDinan Timothy GClarke GerardO'Mahony Siobhain MSchellekens Harriët - Prodigiosin is naturally synthesized red pigment derived from Serratia marcescens. The present study probes into one-step cost-effective production, characterization as well as in vitro antioxidant and anticancer activity. The statistical optimization of the surface area and moisture content of peanut oil cake as a solid substrate leads to a fifty-fold increase in prodigiosin production. Prodigiosin extracted from Serratia marcescens strain BAB 3285 was purified in acidified methanol and further characterized by HPLC and LC-MS/MS to confirm its purity, integrity, and molecular mass. The pigment demonstrated strong free radical scavenging potential, effective staining properties across diverse fabric types, and significant inhibitory activity against infectious organisms, including clinical dermatophytic fungi and bacterial pathogens. Furthermore, antiproliferative assays revealed IC50 values of 134 ± 1.7 µM against the MCF-7 breast cancer cell line and 397 ± 7.9 µM against the normal fibroblast cell line, indicating selective cytotoxicity. Further, saleable cost comparison for 1 mg of purified prodigiosin obtained from present study compared to conventional media, modified media I and modified media II in the reported study are ∼2713.11 INR (∼32.6$), ∼20,302.46 INR (∼243.96$), 9,229.41 INR (∼110.91$) and 14,502.66 INR (∼174.27$) respectively. The economic gain achieved as well as potential activities in the present study is remarkable which can be further upscale and commercialized for industrial production. - Source: PubMed
Publication date: 2026/02/19
Shekh SatyamitraRathore Dalip SinghRaval UrviParjapati BhumikaJhala DhwaniRaval SakshiPatel AmrutlalJoshi MadhviJoshi Chaitanya GSingh Niraj Kumar - Leptin receptor-expressing hypothalamic neurons (LepR ) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We profiled ∼20,000 LepR nuclei using single-nucleus multiome (snRNA-seq/snATAC-seq), identifying 39 transcriptionally and epigenetically distinct clusters, including AgRP (two subtypes), Pomc (two subtypes), Foxb1, Irx5/3 (three subtypes), Nts, PNOC (two subtypes), Kiss1/Pdyn (KNDy, two subtypes), Ghrh, Tcf7l2, and Sf1/Nr5a1 (three subtypes) populations. We also identified three Glp1r-expressing clusters with the highest Lepr enrichment, each marked by distinct molecular signatures. Cluster-specific open chromatin regions (OCRs) delineated putative cis-regulatory elements unique to each LepR subtype. Mouse cell-type specific OCRs conserved in the human genome were identified; a subset were proximal to genes with high Human Genetic Evidence (HuGE) scores for obesity-related traits, overlapped obesity-associated GWAS loci, and/or coincided with eQTLs, including variants with the potential to influence human energy balance. Together, these data provide cell type-specific cis-regulatory atlas of LepR neuronal subtypes, including Glp1r/Lepr-enriched populations, and highlight evolutionarily conserved, subtype-specific regulatory elements, associated candidate genes, and putative functional variants that may modulate LepR subtype function and influence energy homeostasis and obesity susceptibility in humans. - Source: PubMed
Publication date: 2025/10/07
Heyward Frankie DPan HuiDreyfuss Jonathan M - Resistance to the proteasome inhibitor bortezomib is a major obstacle to the treatment of multiple myeloma (MM) and a major cause of relapse and death. Investigating the role of bortezomib resistance genes in MM is crucial. This study aimed to evaluate the potential of bortezomib resistance-related genes (BRGs) as prognostic biomarkers in MM. - Source: PubMed
Publication date: 2026/01/06
Ding YangyangXiao MengZhu JinliJiao XunyiGuo JinjingShudao XiongWang Jiajia